EFSA Compendium of Botanicals

Draft - work in progress

Parsnip (as plant) // Pastinaca sativa L.

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 635
Number of processed references:: 6

Compositions

#1: Isopimpinellin #2: Xanthotoxol #3: Falcarindiol #4: Isopimpinellin #5: Psoralen #6: Xanthotoxin #7: trioxsalen #8: Bergapten #9: Sphondin #10: Isobergapten #11: Pimpinellin #12: Total furanocoumarins #13: Bergapten #14: xanthotoxin (8-methoxypsoralen)

Endpoint Studies

Genotoxicity

Composition #1: Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. Isopimpinellin (HMDB34312).. human metabolome database, 2012, vol. 3.0 . .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

Isopimpinellin (RF-00003784-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isopimpinellin

Composition #2: Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. Xanthotoxol (HMDB29457).. human metabolome database, 2012, vol. 3.0 . .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Xanthotoxol (RF-00011114-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Xanthotoxol

Composition #3: Zidorn, C., Johrer, K., Ganzera, M., Schubert, B., Sigmund, EM., Mader, J., Greil, R., Ellmerer, EP., Stuppner, H. Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley, and parsnip and their cytotoxic activities. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2005, vol. 53, no. 7, p. 2518–2523. DOI: 10.1021/jf048041s. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Freeze-dried plant material, CH2Cl2
Substance:

falcarindiol (RF-00003811-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

NMR, IR, MS, HPLC, Column Chromatography
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.77
Internal remarks:

Falcarindiol

Composition #4: Peroutka, Radek., Schulzova, Vera., Botek, Petr., Hajslova, Jana. Analysis of furanocoumarins in vegetables (Apiaceae) anal citrus fruits (Rutaceae). JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2007, vol. 87, no. 11, p. 2152–2163. DOI: 10.1002/jsfa.2979. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethyl acetate
Substance:

Isopimpinellin (RF-00003784-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

HPLC, MS, UV, GC
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.7-8.3
Internal remarks:

Isopimpinellin

Composition #5: Peroutka, Radek., Schulzova, Vera., Botek, Petr., Hajslova, Jana. Analysis of furanocoumarins in vegetables (Apiaceae) anal citrus fruits (Rutaceae). JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2007, vol. 87, no. 11, p. 2152–2163. DOI: 10.1002/jsfa.2979. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethyl acetate
Substance:

psoralen (RF-00004015-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

HPLC, MS, UV, GC
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<6.6
Internal remarks:

Psoralen

Composition #6: Peroutka, Radek., Schulzova, Vera., Botek, Petr., Hajslova, Jana. Analysis of furanocoumarins in vegetables (Apiaceae) anal citrus fruits (Rutaceae). JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2007, vol. 87, no. 11, p. 2152–2163. DOI: 10.1002/jsfa.2979. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethyl acetate
Substance:

Methoxsalen Methoxsalen (RF-00003863-PAR)
Additional substance description:

Xanthotoxin
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

HPLC, MS, UV, GC
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.1-28
Internal remarks:

Xanthotoxin

Composition #7: Peroutka, Radek., Schulzova, Vera., Botek, Petr., Hajslova, Jana. Analysis of furanocoumarins in vegetables (Apiaceae) anal citrus fruits (Rutaceae). JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2007, vol. 87, no. 11, p. 2152–2163. DOI: 10.1002/jsfa.2979. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethyl acetate
Substance:

Furanocoumarins (RF-00004381-PAR)
Additional substance description:

trioxsalen
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

HPLC, MS, UV, GC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

trioxsalen

Composition #8: Peroutka, Radek., Schulzova, Vera., Botek, Petr., Hajslova, Jana. Analysis of furanocoumarins in vegetables (Apiaceae) anal citrus fruits (Rutaceae). JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2007, vol. 87, no. 11, p. 2152–2163. DOI: 10.1002/jsfa.2979. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethyl acetate
Substance:

Bergapten (RF-00003837-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

HPLC, MS, UV, GC
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.9-9
Internal remarks:

Bergapten

Composition #9: Peroutka, Radek., Schulzova, Vera., Botek, Petr., Hajslova, Jana. Analysis of furanocoumarins in vegetables (Apiaceae) anal citrus fruits (Rutaceae). JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2007, vol. 87, no. 11, p. 2152–2163. DOI: 10.1002/jsfa.2979. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethyl acetate
Substance:

sphondin (RF-00004060-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

HPLC, MS, UV, GC
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.2-4.9
Internal remarks:

Sphondin

Composition #10: Peroutka, Radek., Schulzova, Vera., Botek, Petr., Hajslova, Jana. Analysis of furanocoumarins in vegetables (Apiaceae) anal citrus fruits (Rutaceae). JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2007, vol. 87, no. 11, p. 2152–2163. DOI: 10.1002/jsfa.2979. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethyl acetate
Substance:

isobergapten (RF-00003441-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

HPLC, MS, UV, GC
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.0-16.3
Internal remarks:

Isobergapten

Composition #11: Peroutka, Radek., Schulzova, Vera., Botek, Petr., Hajslova, Jana. Analysis of furanocoumarins in vegetables (Apiaceae) anal citrus fruits (Rutaceae). JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2007, vol. 87, no. 11, p. 2152–2163. DOI: 10.1002/jsfa.2979. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethyl acetate
Substance:

pimpinellin (RF-00003997-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

HPLC, MS, UV, GC
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

< 0.7
Internal remarks:

Pimpinellin

Composition #12: Peroutka, Radek., Schulzova, Vera., Botek, Petr., Hajslova, Jana. Analysis of furanocoumarins in vegetables (Apiaceae) anal citrus fruits (Rutaceae). JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2007, vol. 87, no. 11, p. 2152–2163. DOI: 10.1002/jsfa.2979. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethyl acetate
Substance:

Furanocoumarins (RF-00004381-PAR)
Additional substance description:

Total furanocoumarins
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

HPLC, MS, UV, GC
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5-89
Internal remarks:

Total furanocoumarins

Composition #13: Luszczki, Jarogniew J., Andres-Mach, Marta., Glensk, Michal., Skalicka-Wozniak, Krystyna. Anticonvulsant effects of four linear furanocoumarins, bergapten, imperatorin, oxypeucedanin, and xanthotoxin, in the mouse maximal electroshock-induced seizure model: a comparative study. PHARMACOLOGICAL REPORTS, 2010, vol. 62, no. 6, p. 1231–1236. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether
Substance:

Bergapten (RF-00003837-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC and 1H-NMR analyses
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Bergapten

Composition #14: Skalicka-Wozniak, Krystyna., Zagaja, Miroslaw., Glowniak, Kazimierz., Luszczki, Jarogniew J. Purification and anticonvulsant activity of xanthotoxin (8-methoxypsoralen). CENTRAL EUROPEAN JOURNAL OF BIOLOGY, 2014, vol. 9, no. 4, p. 431–436. DOI: 10.2478/s11535-013-0275-9. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2Cl2
Substance:

Methoxsalen Methoxsalen (RF-00003863-PAR)
Additional substance description:

Xanthotoxin, 8-methosypsoralen
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

High-performance counter-current chromatographic
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.1
Internal remarks:

xanthotoxin (8-methoxypsoralen)