EFSA Compendium of Botanicals

Draft - work in progress

Passiflora caerulea L.

Family:: Passifloraceae
Approval state:: Approved
Number of articles retrieved:: 144
Number of processed references:: 1

Compositions

#1: Harmane alkaloids (harmane) #2: Harmine #3: Harmol

Endpoint Studies

#1: Aqueous extract: Decreased rotarod performance and decreased grooming behavior in both males and females. #2: Ethanol extract: In both males and females: Decreased rotarod performance after 30 and 90 days. Increased rearing behaviour in females after 15 and 30 days. Increased grooming behavior in males after 30 and 90 days and females after 90 days. #3: Alkaloid extract: In both males and females: Decreased rotarod performance after both 30 and 90 days. Increased ambulation activity of females in open field test after 90 days. Increased rearing activity in females after 90 days. Increased grooming behaviour in males after 30 and 90 days and females after 90 days.

Genotoxicity

Composition #1: Zacchino, S., Rodriguez, G., Pennachioni, P., Flores, S., Furlan, R., De Duffard, A. M. Evangelista., Duffard, R. Preliminary toxicological study in rats of Passiflora caerulea extracts. fitoterapia, 1997, vol. 68, no. 3, p. 265–271. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol,CHCl3
Substance:

harmane alkaloids (RF-00004301-PAR)
Additional substance description:

harmane
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Harmane alkaloids (harmane)

Composition #2: Zacchino, S., Rodriguez, G., Pennachioni, P., Flores, S., Furlan, R., De Duffard, A. M. Evangelista., Duffard, R. Preliminary toxicological study in rats of Passiflora caerulea extracts. fitoterapia, 1997, vol. 68, no. 3, p. 265–271. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol,CHCl3
Substance:

harmine (RF-00003854-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Harmine

Composition #3: Zacchino, S., Rodriguez, G., Pennachioni, P., Flores, S., Furlan, R., De Duffard, A. M. Evangelista., Duffard, R. Preliminary toxicological study in rats of Passiflora caerulea extracts. fitoterapia, 1997, vol. 68, no. 3, p. 265–271. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol,CHCl3
Substance:

Harmol (RF-00011120-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Harmol

Endpoint study #1: Zacchino, S., Rodriguez, G., Pennachioni, P., Flores, S., Furlan, R., De Duffard, A. M. Evangelista., Duffard, R. Preliminary toxicological study in rats of Passiflora caerulea extracts. fitoterapia, 1997, vol. 68, no. 3, p. 265–271. .

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Drying (dehydration) (A07KG)
Additional plant/substance description:

Aqueous extract (tea)
Type of toxicological test:

subchronic (CHD013TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male/Female
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

90.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

12
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

428
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Central Nervous System (TT035A)
Effect description:

Decreased rotarod performance in both males and females
Effect or parameter linked to the endpoint:

behaviour (CHD001BE)
Internal remarks:

Aqueous extract: Decreased rotarod performance and decreased grooming behavior in both males and females.

Endpoint study #2: Zacchino, S., Rodriguez, G., Pennachioni, P., Flores, S., Furlan, R., De Duffard, A. M. Evangelista., Duffard, R. Preliminary toxicological study in rats of Passiflora caerulea extracts. fitoterapia, 1997, vol. 68, no. 3, p. 265–271. .

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Drying (dehydration) (A07KG)
Additional plant/substance description:

Ethanol extract
Type of toxicological test:

subchronic (CHD013TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male/Female
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

90.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

12
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

428
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Central Nervous System (TT035A)
Effect description:

In both males and females: Decreased rotarod performance after 30 and 90 days. Increased rearing behaviour in females after 15 and 30 days. Increased grooming behavior in males after 30 and 90 days and females after 90 days.
Effect or parameter linked to the endpoint:

mobility (CHD011BE)
Internal remarks:

Ethanol extract: In both males and females: Decreased rotarod performance after 30 and 90 days. Increased rearing behaviour in females after 15 and 30 days. Increased grooming behavior in males after 30 and 90 days and females after 90 days.

Endpoint study #3: Zacchino, S., Rodriguez, G., Pennachioni, P., Flores, S., Furlan, R., De Duffard, A. M. Evangelista., Duffard, R. Preliminary toxicological study in rats of Passiflora caerulea extracts. fitoterapia, 1997, vol. 68, no. 3, p. 265–271. .

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Drying (dehydration) (A07KG)
Additional plant/substance description:

Alkaloid rich extract (Ethanol, CHCl3; constitutes 0.17% of dried aerial plant)
Type of toxicological test:

subchronic (CHD013TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male/Female
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

90.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

12
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

856
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Central Nervous System (TT035A)
Effect description:

Decreased rotarod performance after 30 and 90 days (Males & females). Increased ambulation activity and increased rearing activity in females after 90 days. Increased grooming behaviour in males after 30 and 90 days and females after 90 days.
Effect or parameter linked to the endpoint:

mobility (CHD011BE)
Internal remarks:

Alkaloid extract: In both males and females: Decreased rotarod performance after both 30 and 90 days. Increased ambulation activity of females in open field test after 90 days. Increased rearing activity in females after 90 days. Increased grooming behaviour in males after 30 and 90 days and females after 90 days.