EFSA Compendium of Botanicals

Draft - work in progress

Papaver bracteatum Lindl.

Family:: Papaveraceae
Approval state:: Approved
Number of articles retrieved:: 318
Number of processed references:: 4

Compositions

#1: Bracteoline in the capsules #2: protopine (capsule) #3: alpinine (capsule) #4: Thebaine (roots) #5: Thebaine (flower, petal) #6: Thebaine (leaves) #7: Thebaine (capsule = fruit peel) #8: Thebaine (capsule content = seed) #9: oripavine (capsule) #10: Isothebaine (capsule) #11: Thebaine (capsule) #12: Salutaridine = sinoacutine (capsule)

Endpoint Studies

Genotoxicity

Composition #1: Heydenreich, Kaethe., Pfeifer, Siegfried. Alkaloids of the genus Papaver. XXI. Bracteoline, a new aporphine alkaloid. pharmazie, 1967, p. 124–125. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Additional substance description:

Bracteoline in the capsules
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Bracteoline in the capsules

Composition #2: Theuns, Hubert G., Janssen, Richard H. A. M., Seykens, Don., Salemink, Cornelis A. Alpinine, epialpinine and other alkaloids from Papaver bracteatum. Part 13. Phytochemistry (Elsevier), 1985, p. 581–584. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

protopine (RF-00004010-PAR)
Additional substance description:

in the capsules
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

C and H NMR, GC-MS, TLC
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.002
Internal remarks:

protopine (capsule)

Composition #3: Theuns, Hubert G., Janssen, Richard H. A. M., Seykens, Don., Salemink, Cornelis A. Alpinine, epialpinine and other alkaloids from Papaver bracteatum. Part 13. Phytochemistry (Elsevier), 1985, p. 581–584. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Alpinine (RF-00011031-PAR)
Additional substance description:

in the capsules
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

C and H NMR, GC-MS, TLC
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.003
Internal remarks:

alpinine (capsule)

Composition #4: Rezaei, Mahdi., Naghavi, Mohamad Reza., Hoseinzade, Abdol Hadi., Abbasi, Alireza. Developmental accumulation of thebaine and some gene transcripts in different organs of Papaver bracteatum. Industrial Crops and Products, 2016, p. 262–268. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Thebaine (RF-00000254-TOX)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

Ion Mobility Spectometry
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.6-10.3
Internal remarks:

Thebaine (roots)

Composition #5: Rezaei, Mahdi., Naghavi, Mohamad Reza., Hoseinzade, Abdol Hadi., Abbasi, Alireza. Developmental accumulation of thebaine and some gene transcripts in different organs of Papaver bracteatum. Industrial Crops and Products, 2016, p. 262–268. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Thebaine (RF-00000254-TOX)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

Ion Mobility Spectometry
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.6-7.5
Internal remarks:

Thebaine (flower, petal)

Composition #6: Rezaei, Mahdi., Naghavi, Mohamad Reza., Hoseinzade, Abdol Hadi., Abbasi, Alireza. Developmental accumulation of thebaine and some gene transcripts in different organs of Papaver bracteatum. Industrial Crops and Products, 2016, p. 262–268. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Thebaine (RF-00000254-TOX)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

Ion Mobility Spectometry
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.0-6.4
Internal remarks:

Thebaine (leaves)

Composition #7: Rezaei, Mahdi., Naghavi, Mohamad Reza., Hoseinzade, Abdol Hadi., Abbasi, Alireza. Developmental accumulation of thebaine and some gene transcripts in different organs of Papaver bracteatum. Industrial Crops and Products, 2016, p. 262–268. .

Language:

English (en)
Plant part:

Fruit peel (as part-nature) (A067G)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Thebaine (RF-00000254-TOX)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

Ion Mobility Spectometry
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.0-10.7
Internal remarks:

Thebaine (capsule = fruit peel)

Composition #8: Rezaei, Mahdi., Naghavi, Mohamad Reza., Hoseinzade, Abdol Hadi., Abbasi, Alireza. Developmental accumulation of thebaine and some gene transcripts in different organs of Papaver bracteatum. Industrial Crops and Products, 2016, p. 262–268. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Thebaine (RF-00000254-TOX)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

Ion Mobility Spectometry
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.4-7.6
Internal remarks:

Thebaine (capsule content = seed)

Composition #9: Sanyar, G., Gulgeze, H B., Gozler, B. Salutaridine N-Oxide from the Capsules of Papaver bracteatum.. Planta medica, 1992, vol. 58, no. 4, p. 368–9. DOI: 10.1055/s-2006-961487. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Oripavine (RF-00004736-PAR)
Additional substance description:

in the capsules
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

CC, TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

oripavine (capsule)

Composition #10: Sanyar, G., Gulgeze, H B., Gozler, B. Salutaridine N-Oxide from the Capsules of Papaver bracteatum.. Planta medica, 1992, vol. 58, no. 4, p. 368–9. DOI: 10.1055/s-2006-961487. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

isothebaine (RF-00003453-PAR)
Additional substance description:

in the capsules
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

CC, TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isothebaine (capsule)

Composition #11: Sanyar, G., Gulgeze, H B., Gozler, B. Salutaridine N-Oxide from the Capsules of Papaver bracteatum.. Planta medica, 1992, vol. 58, no. 4, p. 368–9. DOI: 10.1055/s-2006-961487. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Thebaine (RF-00000254-TOX)
Additional substance description:

in the capsules
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

CC, TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Thebaine (capsule)

Composition #12: Sanyar, G., Gulgeze, H B., Gozler, B. Salutaridine N-Oxide from the Capsules of Papaver bracteatum.. Planta medica, 1992, vol. 58, no. 4, p. 368–9. DOI: 10.1055/s-2006-961487. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

sinoacutine (RF-00004056-PAR)
Additional substance description:

Salutaridine in the capsules
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

CC, TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Salutaridine = sinoacutine (capsule)