EFSA Compendium of Botanicals

Draft - work in progress

Oplopanax horridus (Sm.) Miq.

Family:: Araliaceae
Approval state:: Approved
Number of articles retrieved:: 97
Number of processed references:: 4

Compositions

#1: Acankoreoside A #2: Phenylpropenoids #3: Coumarins #4: Lignans #5: Polyacetylene derivatives #6: falcarindiol #7: S-falcarinol

Endpoint Studies

Genotoxicity

Composition #1: Cao, Kai-yue., Qiao, Chun-feng., Chen, Xian-qiang., Wang, Chong-zhi., Yuan, Chun-su., Zhao, Jing., Li, Shao-ping. Chemical constituents from leaves of oplopanax horridus. Chinese Herbal Medicines, 2014, p. 328–331. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

acankoreoside A
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Acankoreoside A

Composition #2: Huang, Wei-Hua., Luo, Wei., Wang, Chong-Zhi., Yuan, Chun-Su., Nie, Ming-Kun., Shi, Shu-Yun., Zhou, Hong-Hao., Ouyang, Dong-Sheng. Phenolic constituents from Oplopanax horridus .. zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2014, vol. 39, no. 10, p. 1852–7. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extract of root bark
Substance:

phenylpropenoids (RF-00010799-PAR)
Additional substance description:

3-acetylcaffeic acid; homovanillyl alcohol 4-O-b-D-glucopyranoside; 3-hydroxyphenethyl alcohol 4-O-b-D-glucopyranoside; 3, 5-dimethoxycinnamyl alcohol 4-O-b-D-glucopyranoside; 3-dimethoxycinnamyl alcohol 4-O-b-D-glucopyranoside
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Phenylpropenoids

Composition #3: Huang, Wei-Hua., Luo, Wei., Wang, Chong-Zhi., Yuan, Chun-Su., Nie, Ming-Kun., Shi, Shu-Yun., Zhou, Hong-Hao., Ouyang, Dong-Sheng. Phenolic constituents from Oplopanax horridus .. zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2014, vol. 39, no. 10, p. 1852–7. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extract of root bark
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

scopoletin; esculetin; 3'-angeloyl-4'-acetyl-cis-knellactone
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins

Composition #4: Huang, Wei-Hua., Luo, Wei., Wang, Chong-Zhi., Yuan, Chun-Su., Nie, Ming-Kun., Shi, Shu-Yun., Zhou, Hong-Hao., Ouyang, Dong-Sheng. Phenolic constituents from Oplopanax horridus .. zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2014, vol. 39, no. 10, p. 1852–7. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extract of root bark
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

6 lignans isolated from root bark
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans

Composition #5: Huang, Weihua., Yang, Jing., Zhao, Jing., Wang, Chong-zhi., Yuan, Chun-su., Li, Shao-ping. Quantitative analysis of six polyynes and one polyene in Oplopanax horridus and Oplopanax elatus by pressurized liquid extraction and on-line SPE-HPLC. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2010, vol. 53, no. 4, p. 906–910. DOI: 10.1016/j.jpba.2010.06.021. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

polyacetylene derivatives polyacetylene derivatives (RF-00004332-PAR)
Additional substance description:

Concentration (mg/L): oplopandiol (1.94-4.13 ); oplopandiol acetate (2.35-4.26); oplopantriol A (0.29-1.49); oplopantriol B (0.25-1.28); (11S,16S,9Z)-9,17-octadecadiene-12,14-diyne-1,11,16-triol,1-acetate (0.77-1.04)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

highperformance liquid chromatography (SPE–HPLC)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Polyacetylene derivatives

Composition #6: Huang, Weihua., Yang, Jing., Zhao, Jing., Wang, Chong-zhi., Yuan, Chun-su., Li, Shao-ping. Quantitative analysis of six polyynes and one polyene in Oplopanax horridus and Oplopanax elatus by pressurized liquid extraction and on-line SPE-HPLC. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2010, vol. 53, no. 4, p. 906–910. DOI: 10.1016/j.jpba.2010.06.021. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

falcarindiol (RF-00003811-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

highperformance liquid chromatography (SPE–HPLC)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.60-6.68
Internal remarks:

falcarindiol

Composition #7: Shao, Li., Bao, Mei-Hua., Ouyang, Dong-Sheng., Wang, Chong-Zhi., Yuan, Chun-Su., Zhou, Hong-Hao., Huang, Wei-Hua. Unstable Simple Volatiles and Gas Chromatography-Tandem Mass Spectrometry Analysis of Essential Oil from the Roots Bark of Oplopanax Horridus Extracted by Supercritical Fluid Extraction . molecules, 2014, vol. 19, no. 12, p. 19708–19717. DOI: 10.3390/molecules191219708. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Super-critical gas extraction (A0BZQ)
Additional extraction description:

volatile oil extracted from root bark
Substance:

falcarindiol (RF-00003811-PAR)
Additional substance description:

concentration in volatile oil
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.6
Internal remarks:

S-falcarinol