EFSA Compendium of Botanicals

Draft - work in progress

Oplopanax elatus (Nakai) Nakai

Family:: Araliaceae
Approval state:: Approved
Number of articles retrieved:: 92
Number of processed references:: 7

Compositions

#1: Saponins (cirensenosides O and P) #2: Pentacyclic triterpene saponins (cirenshenoside S, T, U, V) #3: Emodin #4: Aloe-emodin #5: Chrysophanol #6: Physcion #7: Saponins #8: p-Coumaric acid in roots #9: p-Coumaric acid in leaves #10: p-Coumaric acid in stems #11: Polyacetylene derivative (oplopandiol) #12: falcarindiol #13: Triterpene saponins (Cirensenoside M&N)

Endpoint Studies

Genotoxicity

Composition #1: Wang, G. S., Chen, Y. P., Xu, J. D., Murayama, T., Shoji, J. Isolation and structure elucidation of cirensenosides O and P from the leaves of Oplopanax elatus Nakai . yaoxue xuebao, 1996, vol. 31, no. 12, p. 940–944. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Additional extraction description:

unspecified
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

Cirensenosides O and P
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

spectroscopy
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins (cirensenosides O and P)

Composition #2: Wang Guang-shu., Yang Xiao-Hong., Xu Jing-da. Structures of four new triterpenoid saponins from the leaves of Oplopanax elatus Nakai. Yaoxue Xuebao, 2004, vol. 39, no. 5, p. 354–358. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

Cirenshenoside S, T, U & V
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

IR, NMR, GLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pentacyclic triterpene saponins (cirenshenoside S, T, U, V)

Composition #3: Xu, Song., Liang, Huaqing. Studies on anthraquinones of Tall oplopanax (Oplopanax elatus). zhongcaoyao, 1998, p. 222–223. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

Emodin (RF-00003798-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Emodin

Composition #4: Xu, Song., Liang, Huaqing. Studies on anthraquinones of Tall oplopanax (Oplopanax elatus). zhongcaoyao, 1998, p. 222–223. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

Aloe-emodin (RF-00003670-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aloe-emodin

Composition #5: Xu, Song., Liang, Huaqing. Studies on anthraquinones of Tall oplopanax (Oplopanax elatus). zhongcaoyao, 1998, p. 222–223. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

chrysophanol (RF-00003737-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Chrysophanol

Composition #6: Xu, Song., Liang, Huaqing. Studies on anthraquinones of Tall oplopanax (Oplopanax elatus). zhongcaoyao, 1998, p. 222–223. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

physcion (RF-00003993-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Physcion

Composition #7: Wang, G., Meng, Q., Xu, J. Glycosides in the leaves of Oplopanax elatus Nakai. chinese pharmaceutical journal, 1996, vol. 31, no. 9, p. 523–524. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Additional extraction description:

unspecified
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

Two saponins: D-glucopyranoside; 3-epibetulinic acid 28-O-α-L-rhamnopyranosyl (1 → 4)-β-D-glucopyranosyl (1 → 6)-β-D-glucopyranoside
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

spectroscopy
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #8: Kim, Jun Heong. Assessment on Antioxidant Properties of Oplopanax elatus Nakai in vitro. KOREAN JOURNAL OF MEDICINAL CROP SCIENCE, 2007, vol. 15, no. 2, p. 112–119. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

various types of extracts used
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

+ UV
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

36.4-819.4
Internal remarks:

p-Coumaric acid in roots

Composition #9: Kim, Jun Heong. Assessment on Antioxidant Properties of Oplopanax elatus Nakai in vitro. KOREAN JOURNAL OF MEDICINAL CROP SCIENCE, 2007, vol. 15, no. 2, p. 112–119. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hexane and ethylacetate
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

+ UV
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

87.5-170.7
Internal remarks:

p-Coumaric acid in leaves

Composition #10: Kim, Jun Heong. Assessment on Antioxidant Properties of Oplopanax elatus Nakai in vitro. KOREAN JOURNAL OF MEDICINAL CROP SCIENCE, 2007, vol. 15, no. 2, p. 112–119. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hexane and ethylacetate
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

+ UV
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

98.1-1114.7
Internal remarks:

p-Coumaric acid in stems

Composition #11: Huang, Weihua., Yang, Jing., Zhao, Jing., Wang, Chong-zhi., Yuan, Chun-su., Li, Shao-ping. Quantitative analysis of six polyynes and one polyene in Oplopanax horridus and Oplopanax elatus by pressurized liquid extraction and on-line SPE-HPLC. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2010, vol. 53, no. 4, p. 906–910. DOI: 10.1016/j.jpba.2010.06.021. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

polyacetylene derivatives polyacetylene derivatives (RF-00004332-PAR)
Additional substance description:

oplopandiol
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

SPE-HPLC
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

29.89-37.69
Internal remarks:

Polyacetylene derivative (oplopandiol)

Composition #12: Huang, Weihua., Yang, Jing., Zhao, Jing., Wang, Chong-zhi., Yuan, Chun-su., Li, Shao-ping. Quantitative analysis of six polyynes and one polyene in Oplopanax horridus and Oplopanax elatus by pressurized liquid extraction and on-line SPE-HPLC. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2010, vol. 53, no. 4, p. 906–910. DOI: 10.1016/j.jpba.2010.06.021. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

falcarindiol (RF-00003811-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

SPE-HPLC
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

49.87-52.07
Internal remarks:

falcarindiol

Composition #13: Wang, GS., Xu, JD., Ma, XL., Sun, YX., Liu, JZ., Murayama, T., Shoji, J. Chemical studies on the glycosides in the leaves of Oplopanax elatus Nakai .4.. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 1997, vol. 13, no. 1, p. 34–38. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

Cirensenoside M & N
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Triterpene saponins (Cirensenoside M&N)