EFSA Compendium of Botanicals

Draft - work in progress

Notopterygium incisum K.C.Ting ex H.T.Chang

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 241
Number of processed references:: 7

Compositions

#1: Isoimperatorin #2: Bergapten #3: Isoimperatorin #4: Bergapten #5: Notopterol #6: Furanocoumarins #7: Notopterol #8: Isoimperatorin #9: Alkaloids #10: Polyacetylenes

Endpoint Studies

#1: Photosensitisation

Genotoxicity

Composition #1: Matsuda, H., Hirata, N., Kawaguchi, Y., Yamazaki, M., Naruto, S., Shibano, M., Masahiko, TI., Baba, K., Kubo, M. Melanogenesis stimulation in murine B16 melanoma cells by Umberiferae plant extracts and their coumarin constituents. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, vol. 28, no. 7, p. 1229–1233. DOI: 10.1248/bpb.28.1229. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

isoimperatorin (RF-00003880-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Percent (G138A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.11
Internal remarks:

Isoimperatorin

Composition #2: Matsuda, H., Hirata, N., Kawaguchi, Y., Yamazaki, M., Naruto, S., Shibano, M., Masahiko, TI., Baba, K., Kubo, M. Melanogenesis stimulation in murine B16 melanoma cells by Umberiferae plant extracts and their coumarin constituents. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, vol. 28, no. 7, p. 1229–1233. DOI: 10.1248/bpb.28.1229. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

Bergapten (RF-00003837-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0008
Internal remarks:

Bergapten

Composition #3: Qian, Guang-Sheng., Wang, Qing., Leung, Kelvin Sze-Yin., Qin, Yong., Zhao, Zhongzhen., Jiang, Zhi-Hong. Quality assessment of Rhizoma et Radix Notopterygii by HPTLC and HPLC fingerprinting and HPLC quantitative analysis . journal of pharmaceutical and biomedical analysis, 2007, vol. 44, no. 3, p. 812–817. DOI: 10.1016/j.jpba.2007.03.029. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

isoimperatorin (RF-00003880-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Gram/100 gram (G013A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.22-0.82
Internal remarks:

Isoimperatorin

Composition #4: Qian, Guang-Sheng., Wang, Qing., Leung, Kelvin Sze-Yin., Qin, Yong., Zhao, Zhongzhen., Jiang, Zhi-Hong. Quality assessment of Rhizoma et Radix Notopterygii by HPTLC and HPLC fingerprinting and HPLC quantitative analysis . journal of pharmaceutical and biomedical analysis, 2007, vol. 44, no. 3, p. 812–817. DOI: 10.1016/j.jpba.2007.03.029. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Bergapten (RF-00003837-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Gram/100 gram (G013A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.019-0.075
Internal remarks:

Bergapten

Composition #5: Qian, Guang-Sheng., Wang, Qing., Leung, Kelvin Sze-Yin., Qin, Yong., Zhao, Zhongzhen., Jiang, Zhi-Hong. Quality assessment of Rhizoma et Radix Notopterygii by HPTLC and HPLC fingerprinting and HPLC quantitative analysis . journal of pharmaceutical and biomedical analysis, 2007, vol. 44, no. 3, p. 812–817. DOI: 10.1016/j.jpba.2007.03.029. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Notopterol (RF-00010980-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Gram/100 gram (G013A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.26-1.24
Internal remarks:

Notopterol

Composition #6: Wu, Shi-Biao., Zhao, Yun., Fan, Hui., Hu, Ying-He., Hamann, Mark T., Peng, Jiang-Nan., Starks, Courtney M., O'Neil-Johnson, Mark., Hu, Jin-Feng. New Guaiane Sesquiterpenes and Furanocoumarins from Notopterygium incisum. PLANTA MEDICA, 2008, vol. 74, no. 15, p. 1812–1817. DOI: 10.1055/s-0028/1088326. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

Furanocoumarins (RF-00004381-PAR)
Additional substance description:

Psoralene derivatives
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furanocoumarins
completed:

True

Composition #7: Liu, Xin., Jiang, Shunyuan., Xu, Kaijie., Sun, Hui., Zhou, Yi., Xu, Xuemin., Yi, Jinhai., Gu, Yucheng., Ding, Lisheng S. Quantitative analysis of chemical constituents in different commercial parts of Notopterygium incisum by HPLC-DAD-MS. JOURNAL OF ETHNOPHARMACOLOGY, 2009, vol. 126, no. 3, p. 474–479. DOI: 10.1016/j.jep.2009.09.011. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Fibrous roots extracted in Methanol
Substance:

Notopterol (RF-00010980-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

11.22-15.56
Internal remarks:

Notopterol

Composition #8: Liu, Xin., Jiang, Shunyuan., Xu, Kaijie., Sun, Hui., Zhou, Yi., Xu, Xuemin., Yi, Jinhai., Gu, Yucheng., Ding, Lisheng S. Quantitative analysis of chemical constituents in different commercial parts of Notopterygium incisum by HPLC-DAD-MS. JOURNAL OF ETHNOPHARMACOLOGY, 2009, vol. 126, no. 3, p. 474–479. DOI: 10.1016/j.jep.2009.09.011. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Fibrous roots extracted in Methanol
Substance:

isoimperatorin (RF-00003880-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.31-7.00
Internal remarks:

Isoimperatorin

Composition #9: Xu, K., Jiang, S., Sun, H., Zhou, Y., Xu, X., Peng, S., Ding, L. New alkaloids from the seeds of Notopterygium incisum. NATURAL PRODUCT RESEARCH, 2012, vol. 26, no. 20, p. 1898–1903. DOI: 10.1080/14786419.2011.628177. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

N-hexacosanoylanthranilic acid, N-octacosanoylanthranilic acid and N-eicosanoyltyramine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #10: Atanasov, Atanas G., Blunder, Martina., Fakhrudin, Nanang., Liu, Xin., Noha, Stefan M., Malainer, Clemens., Kramer, Matthias P., Cocic, Amina., Kunert, Olaf., Schinkovitz, Andreas., Heiss, Elke H., Schuster, Daniela., Dirsch, Verena M., Bauer, Rudolf. Polyacetylenes from Notopterygium incisum-New Selective Partial Agonists of Peroxisome Proliferator-Activated Receptor-Gamma . plos one, 2013, vol. 8, no. 4 . DOI: 10.1371/journal.pone.0061755. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

polyacetylene derivatives polyacetylene derivatives (RF-00004332-PAR)
Additional substance description:

8-acetoxyfalcarinol; falcarindiol and derivatives; crithmumdiol
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Polyacetylenes

Endpoint study #1: Zhou, J., Ouedraogo, M., Qu, F., Duez, P. Potential genotoxicity of traditional Chinese medicinal plants and phytochemicals: An overview. phytotherapy research, 2013, vol. 27, no. 12, p. 1745–1755. DOI: 10.1002/ptr.4942. [DOI link]

Study relevance:

Human health
Substance:

Furanocoumarins (RF-00004381-PAR)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Type of toxicological test:

other (CHD008TT)
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Gram (G148A)
Effect concentration:

3-9
Critical effect:

IMMUNOTOXICITY (TOX09A)
Effect description:

Depending on lightening conditions during the genotoxicity test (micronucleus assay), photosensitization is likely to occur.
Effect or parameter linked to the endpoint:

Phototoxicity (CHD035BE)
Internal remarks:

Photosensitisation