EFSA Compendium of Botanicals

Draft - work in progress

Nardostachys jatamansi (D.Don) DC. // Nardostachys grandiflora DC.

Family:: Caprifoliaceae
Approval state:: Approved
Number of articles retrieved:: 577
Number of processed references:: 7

Compositions

#1: Coumarins in rhizome and root #2: Lignans in rhizome and root #3: Neolignans in rhizome and roots #4: Alkaloids in rhizome and roots #5: Myrcene in essential oil from the roots #6: 1,8-cineole in essential oil from the roots #7: 1,8-cineole in rhizome #8: Actinidine in rhizome #9: Nerolidol-epoxyacetate (epoxide) in rhizome #10: Oroselol and jatamansisn (coumarins) in root essential oil #11: Neolignans in root

Endpoint Studies

#1: Neurotoxicity in rat of ethanolic extract of root at 250 mg/Kg bw and day

Genotoxicity

#1: Genotoxicity

Composition #1: Purnima., Bhatt, Meenakshi., Kothiyal, Preeti. A review article on phytochemistry and pharmacological profiles of Nardostachys jatamansi DC-medicinal herb. journal of pharmacognosy and phytochemistry, 2015, vol. 3, no. 5, p. 102–106. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

coumarins (RF-00004351-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins in rhizome and root

Composition #2: Purnima., Bhatt, Meenakshi., Kothiyal, Preeti. A review article on phytochemistry and pharmacological profiles of Nardostachys jatamansi DC-medicinal herb. journal of pharmacognosy and phytochemistry, 2015, vol. 3, no. 5, p. 102–106. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

lignans (RF-00004361-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans in rhizome and root

Composition #3: Purnima., Bhatt, Meenakshi., Kothiyal, Preeti. A review article on phytochemistry and pharmacological profiles of Nardostachys jatamansi DC-medicinal herb. journal of pharmacognosy and phytochemistry, 2015, vol. 3, no. 5, p. 102–106. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

neolignans (RF-00004386-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Neolignans in rhizome and roots

Composition #4: Purnima., Bhatt, Meenakshi., Kothiyal, Preeti. A review article on phytochemistry and pharmacological profiles of Nardostachys jatamansi DC-medicinal herb. journal of pharmacognosy and phytochemistry, 2015, vol. 3, no. 5, p. 102–106. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in rhizome and roots

Composition #5: Purohit, V.K., Andola, H.C., Bahuguna, Y.M., Gairola, K.C., Haider, S.Z., Arunachalam, K. Volatile constituents of endangered species Nardostachys grandiflora DC. Rhizomes from Uttarakhand Himalaya (India). indian journal of natural products and resources, 2015, vol. 6, no. 2, p. 134–137. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.2-2.3
Internal remarks:

Myrcene in essential oil from the roots

Composition #6: Purohit, V.K., Andola, H.C., Bahuguna, Y.M., Gairola, K.C., Haider, S.Z., Arunachalam, K. Volatile constituents of endangered species Nardostachys grandiflora DC. Rhizomes from Uttarakhand Himalaya (India). indian journal of natural products and resources, 2015, vol. 6, no. 2, p. 134–137. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.2-2.3
Internal remarks:

1,8-cineole in essential oil from the roots

Composition #7: Veena, M.E., Niranjana, P., Achur, R.N. Gas chromatography-mass spectrometry analysis of bioactive components from the rhizome extract of Nardostachys jatamansi DC. asian journal of pharmaceutical and clinical research, 2016, vol. 9, no. 3 . .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.02
Internal remarks:

1,8-cineole in rhizome

Composition #8: Veena, M.E., Niranjana, P., Achur, R.N. Gas chromatography-mass spectrometry analysis of bioactive components from the rhizome extract of Nardostachys jatamansi DC. asian journal of pharmaceutical and clinical research, 2016, vol. 9, no. 3 . .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

Actinidine (RF-00004129-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.22
Internal remarks:

Actinidine in rhizome

Composition #9: Veena, M.E., Niranjana, P., Achur, R.N. Gas chromatography-mass spectrometry analysis of bioactive components from the rhizome extract of Nardostachys jatamansi DC. asian journal of pharmaceutical and clinical research, 2016, vol. 9, no. 3 . .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform
Substance:

epoxides (RF-00010829-PAR)
Additional substance description:

Nerolidol-epoxyacetate
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.59
Internal remarks:

Nerolidol-epoxyacetate (epoxide) in rhizome

Composition #10: SHANBHAG, SN., MESTA, CK., MAHESHWA.ML., BHATTACH.SC. TERPENOIDS .75. CONSTITUENTS OF NARDOSTACHYS JATAMANSI AND SYNTHESIS OF (+-) DIHYDROSAMIDIN FROM JATAMANSIN . tetrahedron, 1965, vol. 21, no. 12, p. 3591–&. DOI: 10.1016/S0040-4020(01)96975-3. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

oroselol and jatamansin
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Oroselol and jatamansisn (coumarins) in root essential oil

Composition #11: REILLY, MJ., WALLIS, AFA., LUNDQUIST, K., STOMBERG, R. STEREOCHEMISTRY OF NEOLIGNANS - A REVISED STRUCTURE FOR A NEOLIGNAN ISOLATED FROM THE ROOTS OF PIPER-CAPENSE . journal of wood chemistry and technology, 1992, vol. 12, no. 4, p. 471–483. DOI: 10.1080/02773819208545792. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

neolignans (RF-00004386-PAR)
Additional substance description:

Virolin, Erythrovirolin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Neolignans in root

Endpoint study #1: Rao, VS., Rao, A., Karanth, KS. Anticonvulsant and neurotoxicity profile of Nardostachys jatamansi in rats . journal of ethnopharmacology, 2005, vol. 102, no. 3, p. 351–356. DOI: 10.1016/j.jep.2005.06.031. [DOI link]

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanolic (95%)
Type of toxicological test:

not reported (CHD015TT)
Tested organism:

Rat (as animal) (A0CNV)
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Number of organisms dosed:

8
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

250
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Central Nervous System (TT035A)
Effect description:

12.5% neurotoxicity; changes in the brain neurotransmitter
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

Neurotoxicity in rat of ethanolic extract of root at 250 mg/Kg bw and day

Genotox #1: Etebari, Mahmoud., Zolfaghari, Behzad., Jafarian-Dehkordi, Abbas., Rakian, Roya. Evaluation of DNA damage of hydro-alcoholic and aqueous extract of Echium amoenum and Nardostachys jatamansi . journal of research in medical sciences, 2012, vol. 17, no. 8, p. 782–786. .

Study category:

Genotoxicity
Type of toxicological test:

single cell gel/comet assay in mammalian cells for detection of DNA damage (CHD040TT)
Method type:

in vitro
Tested organism:

Human (as organism) (A056J)
Strain of test organism:

Hep G2 human cell line (CHD114ST)
Exposure duration for in vivo:

5.0
Unit of exposure duration:

Milligram/millilitre (G191A)
Control groups used:

yes
Endpoint measured:

DNA damage and/or repair
Is genotoxic:

Positive
Remarks on genotox study:

Genotoxocity - aqueous and hydroalcoholic extracts showed genotoxicity at a concentration of 5 mg/ml.
Internal remarks:

Genotoxicity
Internal ID:

WOS:000308361600012