EFSA Compendium of Botanicals

Draft - work in progress

Nandina domestica Thunb.

Family:: Berberidaceae
Approval state:: Approved
Number of articles retrieved:: 313
Number of processed references:: 11

Compositions

#1: Nandinine in root bark #2: Alkaloids in seed pericarp #3: Protopine in the stem #4: Sinoacutine in tree bark #5: Aporphine alkaloids in tree bark #6: Alkaloids in the dried fruit #7: Pseudocolumbamine (alkaloid) in fruit #8: Protocatechuic acid in seed #9: Gallic acid in seed #10: Cyanide in berries #11: Alkaloids in live plant #12: p-hydroxybenzaldehyde in leaves #13: Nandsterine (steroidal alkaloid) in the fruit #14: Alkaloids in the fruit

Endpoint Studies

Genotoxicity

Composition #1: Eijkman, J. F. Active constituents of nandina domestica. chemisches zentralblatt, 1884, p. 779–780. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Nandinine
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Nandinine in root bark

Composition #2: Ohta, Tatsuo. Alkaloids of Nandina domestica. yakugaku zasshi, 1949, p. 502–503. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

from seed pericarp
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.02
Internal remarks:

Alkaloids in seed pericarp

Composition #3: Tomita, Masao., Sugamoto, Motoko. Alkaloids of berberidaceous plant. XXXII. Alkaloids of Nandina domestica forma shinananten. yakugaku zasshi, 1961, p. 1090–1093. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

protopine (RF-00004010-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Protopine in the stem

Composition #4: Kunitomo, Junichi., Juichi, Motoharu., Yoshikawa, Yohko., Chikamatsu, Hiroaki. Structure of nandazurine and isolation of sinoacutine (alkaloids of Nandina domestica). yakugaku zasshi, 1974, p. 97–100. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

sinoacutine (RF-00004056-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sinoacutine in tree bark

Composition #5: Kunitomo, Junichi., Juichi, Motoharu., Yoshikawa, Yohko., Chikamatsu, Hiroaki. Structure of nandazurine and isolation of sinoacutine (alkaloids of Nandina domestica). yakugaku zasshi, 1974, p. 97–100. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Additional substance description:

Nandazurine, O-methyldomesticine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aporphine alkaloids in tree bark

Composition #6: Kunitomo, Junichi., Murakami, Yoshiko. Studies on the alkaloids of Berberidaceae. 38. Alkaloids of dried fruits of Nandina domestica. shoyakugaku zasshi, 1979, p. 84–87. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

O-methyldomesticine, protopine, and isocorydine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in the dried fruit

Composition #7: Moriyasu, Masataka., Ichimaru, Momoyo., Sawada, Yutaka., Izutsu, Kazutaka., Nishiyama, Yumi., Kato, Atsushi. Analysis of alkaloids in Nandina domestica by HPLC and TLC-densitometry. Shoyakugaku Zasshi, 1992, p. 143–149. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Pseudocolumbamine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pseudocolumbamine (alkaloid) in fruit

Composition #8: Peng, Cai-ying., Liu, Jian-qun., Zhang, Rui., Shu, Ji-cheng. Phenolic acid constituents in seeds of Nandina domestica. zhongguo shiyan fangjixue zazhi, 2014, p. 95–98. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecifid
Substance:

3,4-Dihydroxybenzoic acid (RF-00008853-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Protocatechuic acid in seed

Composition #9: Peng, Cai-ying., Liu, Jian-qun., Zhang, Rui., Shu, Ji-cheng. Phenolic acid constituents in seeds of Nandina domestica. zhongguo shiyan fangjixue zazhi, 2014, p. 95–98. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecifid
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Gallic acid in seed

Composition #10: Woldemeskel, Moges., Styer, Eloise L. Feeding Behavior-Related Toxicity due to Nandina domestica in Cedar Waxwings (Bombycilla cedrorum). . veterinary medicine international, 2010, vol. 2010, p. 818159–818159. DOI: 10.4061/2010/818159. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Cyanide (RF-00000021-CHE)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cyanide in berries

Composition #11: Iwasa, Kinuko., Takahashi, Teturo., Nishiyama, Yumi., Moriyasu, Masataka., Sugiura, Makiko., Takeuchi, Atsuko., Tode, Chisato., Tokuda, Harukuni., Takeda, Kazuyoshi. Online structural elucidation of alkaloids and other constituents in crude extracts and cultured cells of Nandina domestica by combination of LC-MS/MS, LC-NMR, and LC-CD analyses. JOURNAL OF NATURAL PRODUCTS, 2008, vol. 71, no. 8, p. 1376–1385. DOI: 10.1021/np8001496. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

(S)-isoboldine, (S)-domesticine, (S)-nantenine, sinoacutine, menispermine, O-Methylpallidine and (E,E)-, (E,Z)-, and (Z,Z)-terrestribisamide
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in live plant

Composition #12: Han, J., Ahn, Y. J., Luo, X. Y. p-hydroxybenzaldehyde, a growth inhibitory chemical extracted from common nandina (Nandina domestica Thunb.) leaf . allelopathy journal, 2011, vol. 28, no. 2, p. 213–224. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

4-Hydroxybenzaldehyde (RF-00001976-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

p-hydroxybenzaldehyde in leaves

Composition #13: Peng, Cai-Ying., Liu, Jian-Qun., Zhang, Rui., Shu, Ji-Cheng. A new alkaloid from the fruit of Nandina domestica Thunb. NATURAL PRODUCT RESEARCH, 2014, vol. 28, no. 15, p. 1159–1164. DOI: 10.1080/14786419.2014.921166. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH (95%)
Substance:

Steroidal alkaloids (RF-00004336-PAR)
Additional substance description:

Nandsterine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Nandsterine (steroidal alkaloid) in the fruit

Composition #14: Peng, Cai-Ying., Liu, Jian-Qun., Zhang, Rui., Shu, Ji-Cheng. A new alkaloid from the fruit of Nandina domestica Thunb. NATURAL PRODUCT RESEARCH, 2014, vol. 28, no. 15, p. 1159–1164. DOI: 10.1080/14786419.2014.921166. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH (95%)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Palmatine , O-methylbulbocapnine , nantenine , dehydronantenine , glaucine , didehydroglaucine , dehydrocorydaline , jatrorrhizine , magnoflorine and berberine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in the fruit