EFSA Compendium of Botanicals

Draft - work in progress

Mimosa tenuiflora (Willd.) Poir.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 232
Number of processed references:: 6

Compositions

#1: Mimonosides A, B and C #2: Tannins #3: Saponins #4: N,N-dimethyltryptamine #5: N,N-dimethyltryptamine

Endpoint Studies

#1: teratogenicity #2: Embryonal death (goats) #3: Teratogenic effect (seeds) #4: Teratogenic effect (leaves)

Genotoxicity

Composition #1: Anton, R., Jiang, Y., Weniger, B., Beck, J.P., Rivier, L. Pharmacognosy of Mimosa tenuiflora (Willd.) Poiret. journal of ethnopharmacology, 1993, vol. 38, no. 2-3, p. 145–152. DOI: 10.1016/0378-8741(93)90010-3. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

butanol
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Additional substance description:

Mimonosides A, B and C
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Mimonosides A, B and C

Composition #2: Meckes-Lozoya M., Lozoya X., Gonzalez J L. Pharmacological properties in vitro of various extracts of Mimosa tenuiflora (tepescohuite). archivos de investigacion medica, 1990, p. 163–169. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate
Substance:

Tannins (RF-00004337-PAR)
Additional substance description:

"high tannin content"
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #3: Meckes-Lozoya M., Lozoya X., Gonzalez J L. Pharmacological properties in vitro of various extracts of Mimosa tenuiflora (tepescohuite). archivos de investigacion medica, 1990, p. 163–169. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

butanol and methanol extracts
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #4: Gaujac, Alain., Martinez, Sabrina Teixeira., Gomes, Arao Araujo., de Andrade, Sandro Jose., Pinto, Angelo da Cunha., David, Jorge Mauricio., Navickiene, Sandro., de Andrade, Jailson Bittencourt. Application of analytical methods for the structural characterization and purity assessment of N,N-dimethyltryptamine, a potent psychedelic agent isolated from Mimosa tenuiflora inner barks. MICROCHEMICAL JOURNAL, 2013, vol. 109, p. 78–83. DOI: 10.1016/j.microc.2012.03.033. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hexane
Substance:

N,N-DIMETHYLTRYPTAMINE (RF-00004089-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

N,N-dimethyltryptamine

Composition #5: Gaujac, Alain., Martinez, Sabrina Teixeira., Gomes, Arao Araujo., de Andrade, Sandro Jose., Pinto, Angelo da Cunha., David, Jorge Mauricio., Navickiene, Sandro., de Andrade, Jailson Bittencourt. Application of analytical methods for the structural characterization and purity assessment of N,N-dimethyltryptamine, a potent psychedelic agent isolated from Mimosa tenuiflora inner barks. MICROCHEMICAL JOURNAL, 2013, vol. 109, p. 78–83. DOI: 10.1016/j.microc.2012.03.033. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hexane
Substance:

N,N-DIMETHYLTRYPTAMINE (RF-00004089-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

N,N-dimethyltryptamine

Endpoint study #1: Riet-Correa, Franklin., Medeiros, Rosane M. T., Schild, Ana Lucia. A review of poisonous plants that cause reproductive failure and malformations in the ruminants of Brazil. JOURNAL OF APPLIED TOXICOLOGY, 2012, vol. 32, no. 4, p. 245–254. DOI: 10.1002/jat.1754. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Goat (as animal) (A057P)
Sex:

Female
Exposure duration:

60.0
Unit of exposure duration:

Day (G134A)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

TERATOGENIC (TOX06A)
Target tissue:

Muscle, Skeletal (TT055A)
Effect description:

up to 100% of newborns affected by malformations
Effect or parameter linked to the endpoint:

morphology (CHD013BE)
Internal remarks:

teratogenicity

Endpoint study #2: Dantas, Antonio Flavio M., Riet-Correa, Franklin., Medeiros, Rosane M. T., Lopes, Jose Radmacyo., Gardner, Dale R., Panter, Kip., Mota, Rinaldo A. Embryonic death in goats caused by the ingestion of Mimosa tenuiflora. TOXICON, 2012, vol. 59, no. 5, p. 555–557. DOI: 10.1016/j.toxicon.2011.11.020. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Fresh (A166Y)
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Goat (as animal) (A057P)
Sex:

Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

60.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

18
Control groups used:

yes
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

Urogenital (TT006A)
Effect description:

Embryonic death if ingested in the first 60 days of gestation.
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Embryonal death (goats)

Endpoint study #3: Gardner, Dale., Riet-Correa, Franklin., Lemos, Danilo., Welch, Kevin., Pfister, James., Panter, Kip. Teratogenic Effects of Mimosa tenuiflora in a Rat Model and Possible Role of N-Methyl- and N,N-Dimethyltryptamine. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2014, vol. 62, no. 30, p. 7398–7401. DOI: 10.1021/jf5005176. [DOI link]

Study relevance:

Human health
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

MeOH
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Other (CHD049ST)
Sex:

Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

15.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

10
Control groups used:

yes
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

TERATOGENIC (TOX06A)
Target tissue:

Muscle, Skeletal (TT055A)
Effect description:

Induction of cranio−facial abnormalities and malformations of the skeletal system in rat pups maybe due to N‑Methyl- and N,N‑Dimethyltryptamine
Effect or parameter linked to the endpoint:

morphology (CHD013BE)
Internal remarks:

Teratogenic effect (seeds)

Endpoint study #4: Gardner, Dale., Riet-Correa, Franklin., Lemos, Danilo., Welch, Kevin., Pfister, James., Panter, Kip. Teratogenic Effects of Mimosa tenuiflora in a Rat Model and Possible Role of N-Methyl- and N,N-Dimethyltryptamine. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2014, vol. 62, no. 30, p. 7398–7401. DOI: 10.1021/jf5005176. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

MeOH
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Other (CHD049ST)
Sex:

Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

15.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

10
Control groups used:

yes
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

TERATOGENIC (TOX06A)
Target tissue:

Muscle, Skeletal (TT055A)
Effect description:

Induction of cranio−facial abnormalities and malformations of the skeletal system in rat pups maybe due to N‑Methyl- and N,N‑Dimethyltryptamine
Effect or parameter linked to the endpoint:

morphology (CHD013BE)
Internal remarks:

Teratogenic effect (leaves)