Draft - work in progress
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- Mimosa pudica L.
Mimosa pudica L.
- Family:
- Fabaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 1245
- Number of processed references:
- 6
Composition #1: Sia, F. Y., Vejayan, J., Jamuna, A., Ambu, S. Efficacy of tannins from Mimosa pudica and tannic acid in neutralizing cobra (Naja kaouthia) venom. JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, 2011, vol. 17, no. 1, p. 42–48. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
deionised water
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Substance:
Tannins (RF-00004337-PAR)
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Analytical method code:
Chromatographic tests (F015A)
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Analytical method - additional description:
Sephadex (LH-20) chromatography
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Tannins
Composition #2: Hullatti, Kirankumar., Pathade, Namrata., Mandavkar, Yuvaraj., Godavarthi, Ashok., Biradi, Mahesh. Bioactivity-guided isolation of cytotoxic constituents from three medicinal plants. PHARMACEUTICAL BIOLOGY, 2013, vol. 51, no. 5, p. 601–606. DOI: 10.3109/13880209.2012.753919.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol
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Substance:
Alkaloids (RF-00004360-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Alkaloids
Composition #3: Hullatti, Kirankumar., Pathade, Namrata., Mandavkar, Yuvaraj., Godavarthi, Ashok., Biradi, Mahesh. Bioactivity-guided isolation of cytotoxic constituents from three medicinal plants. PHARMACEUTICAL BIOLOGY, 2013, vol. 51, no. 5, p. 601–606. DOI: 10.3109/13880209.2012.753919.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol
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Substance:
Saponins (RF-00004333-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Saponins
Composition #4: Hullatti, Kirankumar., Pathade, Namrata., Mandavkar, Yuvaraj., Godavarthi, Ashok., Biradi, Mahesh. Bioactivity-guided isolation of cytotoxic constituents from three medicinal plants. PHARMACEUTICAL BIOLOGY, 2013, vol. 51, no. 5, p. 601–606. DOI: 10.3109/13880209.2012.753919.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol
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Substance:
Tannins (RF-00004337-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Tannins
Composition #5: Patel, Neeraj K., Bhutani, Kamlesh K. SUPPRESSIVE EFFECTS OF MIMOSA PUDICA (L.) CONSTITUENTS ON THE PRODUCTION OF LPS-INDUCED PRO-INFLAMMATORY MEDIATORS . excli journal, 2014, vol. 13, p. 1011–1021. .
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
EtOAc
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Substance:
p-coumaric acid (RF-00010717-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
p-coumaric acid
Composition #6: Patel, Neeraj K., Bhutani, Kamlesh K. SUPPRESSIVE EFFECTS OF MIMOSA PUDICA (L.) CONSTITUENTS ON THE PRODUCTION OF LPS-INDUCED PRO-INFLAMMATORY MEDIATORS . excli journal, 2014, vol. 13, p. 1011–1021. .
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
EtOAc
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Substance:
gallic acid (RF-00003821-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Gallic acid
Composition #7: Patel, Neeraj K., Bhutani, Kamlesh K. SUPPRESSIVE EFFECTS OF MIMOSA PUDICA (L.) CONSTITUENTS ON THE PRODUCTION OF LPS-INDUCED PRO-INFLAMMATORY MEDIATORS . excli journal, 2014, vol. 13, p. 1011–1021. .
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
EtOAc
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Substance:
Mimosine (RF-00011226-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Mimosine
Endpoint study
#1: Nghonjuyi NW., Tiambo CK., Taiwe GS., Toukala JP., Lisita F., Juliano RS., Kimbi HK. Acute and sub-chronic toxicity studies of three plants used in Cameroonianethnoveterinary medicine: Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) leaves,Carica papaya L. (Caricaceae) seeds or leaves, and Mimosa pudica L. (Fabaceae)leaves in Kabir chicks.. Journal of ethnopharmacology, 2016, vol. 178, p. 40–9. DOI: 10.1016/j.jep.2015.11.049.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
ethanol-distilled water
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Type of toxicological test:
subchronic (CHD013TT)
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Tested organism:
Gallus gallus (chicken) (as animal) (A057Z)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
10
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
640
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Effect description:
There were no significant differences in the body weights between control and treated animals of both sexes.
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Effect or parameter linked to the endpoint:
no adverse effect observed at single/highest dose (CHD033BE)
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Internal remarks:
There were no significant differences in the body weights between control and treated animals of both sexes.
Endpoint study
#2: Nghonjuyi NW., Tiambo CK., Taiwe GS., Toukala JP., Lisita F., Juliano RS., Kimbi HK. Acute and sub-chronic toxicity studies of three plants used in Cameroonianethnoveterinary medicine: Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) leaves,Carica papaya L. (Caricaceae) seeds or leaves, and Mimosa pudica L. (Fabaceae)leaves in Kabir chicks.. Journal of ethnopharmacology, 2016, vol. 178, p. 40–9. DOI: 10.1016/j.jep.2015.11.049.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
ethanol-distilled water
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Type of toxicological test:
acute toxicity (CHD016TT)
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Tested organism:
Gallus gallus (chicken) (as animal) (A057Z)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Number of organisms dosed:
10
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
5120
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Effect description:
Since no death or damage was observed throughout the acute toxicity study of Mimosa pudica extracts, the LD50 could not be estimated.
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Effect or parameter linked to the endpoint:
no adverse effect observed at single/highest dose (CHD033BE)
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Internal remarks:
Since no death or damage was observed throughout the acute toxicity study of Mimosa pudica extracts, the LD50 could not be estimated.
Endpoint study
#3: Pokharkar, R.D., Saraswat, R.K., Kanawade, M.G. Contraceptive evaluation of oil extract of seeds of Mimosa pudica (L) in male wistar rats. Pharmacologyonline, 2009, vol. 3, p. 479–488. .
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
oil
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Type of toxicological test:
chronic/long term toxicity (CHD004TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
6
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
millilitre per kilogram (G253A)
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Effect concentration:
0.250
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Critical effect:
REPRODUCTIVE (TOX05A)
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Target tissue:
Urogenital (TT006A)
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Effect description:
Reversible changes in-Weight of cauda-epididymis, weight of testes, testosterone level, sperm count, serum glutamic pyruvic transaminase (SGPT) and alkaline phosphates (Alk.PO4 ).
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
Reversible spermicidal effect
Endpoint study
#4: Gómez Trujillo, Niurka Esther., Corella Del Toro, Isell., Cutié Anido, Yudelkis., Rodríguez Graña, Tania., Salinas Ojeda, Leticia. Hepatotoxicidad aguda de la decocción de la planta Mimosa púdica en ratas Sprague Dawley . correo científico médico, 2014, vol. 18, no. 1, p. 25–32. .
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Study relevance:
Human health
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Plant part:
Unspecified (A07XD)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
decoction
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Type of toxicological test:
acute toxicity (CHD016TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Sprague-Dawley (CHD012ST)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Unit of exposure duration:
Hour (G099A)
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Number of organisms dosed:
5
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Endpoint measured:
Concentration level (CHD013EP)
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Concentration unit:
Milligrams per kilogram body weight (G225A)
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Effect concentration:
500
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Critical effect:
HEPATOTOXICITY (TOX02A)
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Target tissue:
digestive: Liver (TT023A)
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Effect description:
The pathological changes observed were focal periportal necrosis, congestion and centrilobular veins acidophilic degeneration of the liver.
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Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
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Internal remarks:
Hepatotoxicity