EFSA Compendium of Botanicals

Draft - work in progress

Mentha x rotundifolia (L.) Huds.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 148
Number of processed references:: 6

Compositions

#1: 1,2-epoxymenthyl acetate in leaf essential oil #2: Piperitenone oxide (epoxide) in aerial part essential oil #3: Safrole in volatile oil #4: Piperitone #5: 1,8-cineole in leaf essential oil #6: Beta-myrcene in leaf essential oil #7: Menthone + isomenthone #8: Menthofuran #9: Piperitone oxide #10: Menthofuran in leaf essential oil #11: piperitone oxide in leaf essential oil #12: 1,8-cineole in leaf essential oil #13: Myrcene in leaf essential oil #14: carvone in the aerial part essential oil #15: piperitenone oxide (epoxide) in the aerial part essential oil #16: cis-dihydrocarvone in aerial part essential oil #17: piperitone oxide (epoxide) in the aerial part essential oil #18: Myrcene in aerial part essential oil

Endpoint Studies

Genotoxicity

Composition #1: Shibata, Hisao., Shimizu, Sumio. Essential oil of Mentha rotundifolia. VII. Absolute configuration of 1,2-epoxy methyl acetate isolated from a new chemical strain of M. rotundifolia. Agricultural and Biological Chemistry, 1973, p. 2675–2676. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Steam distillation
Substance:

epoxides (RF-00010829-PAR)
Additional substance description:

1,2-epoxymenthyl acetate
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

1,2-epoxymenthyl acetate in leaf essential oil

Composition #2: Bellakhdar, J., Berrada, M., Holeman, M., Ilidrissi, A., Pinel, R. Qualitative and quantitative analysis of oil of Mentha rotundifolia (L.) Hudson ssp eu-rotundifolia var. typica. plantes medicinales et phytotherapie, 1983, p. 33–39. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

unspecified
Substance:

Piperitenone oxide (RF-00008725-PAR)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

62
Internal remarks:

Piperitenone oxide (epoxide) in aerial part essential oil

Composition #3: Liu, Mingchun., Li, Zhengguo., Deng, Wei., Wang, Guomin., Yang, Yingwu. Analysis of volatile oil from Mentha rotundifolia (L.) Huds by gas chromatography-mass spectrometry. jingxi huagong, 2008, p. 1216–1219. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

distillation-extraction-method (SDE)
Substance:

Safrole (RF-00003651-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.9
Internal remarks:

Safrole in volatile oil

Composition #4: Derwich, E., Benziane, Z., Taouil, R., Senhaji, O., Touzani, M. Comparative essential oil composition of leaves of mentha rotundifolia and mentha pulegium a traditional herbal medicine in Morocco. american-eurasian journal of sustainable agriculture, 2010, vol. 4, no. 1, p. 47–54. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

p-Menth-1-en-3-one (RF-00009951-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.1
Internal remarks:

Piperitone

Composition #5: Derwich, E., Benziane, Z., Taouil, R., Senhaji, O., Touzani, M. Comparative essential oil composition of leaves of mentha rotundifolia and mentha pulegium a traditional herbal medicine in Morocco. american-eurasian journal of sustainable agriculture, 2010, vol. 4, no. 1, p. 47–54. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.40
Internal remarks:

1,8-cineole in leaf essential oil

Composition #6: Derwich, E., Benziane, Z., Taouil, R., Senhaji, O., Touzani, M. Comparative essential oil composition of leaves of mentha rotundifolia and mentha pulegium a traditional herbal medicine in Morocco. american-eurasian journal of sustainable agriculture, 2010, vol. 4, no. 1, p. 47–54. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.60
Internal remarks:

Beta-myrcene in leaf essential oil

Composition #7: Derwich, E., Benziane, Z., Taouil, R., Senhaji, O., Touzani, M. Comparative essential oil composition of leaves of mentha rotundifolia and mentha pulegium a traditional herbal medicine in Morocco. american-eurasian journal of sustainable agriculture, 2010, vol. 4, no. 1, p. 47–54. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

menthone (RF-00011280-PAR)
Additional substance description:

+ isomenthone (2.5%)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5
Internal remarks:

Menthone + isomenthone

Composition #8: Derwich, E., Benziane, Z., Taouil, R., Senhaji, O., Touzani, M. Comparative essential oil composition of leaves of mentha rotundifolia and mentha pulegium a traditional herbal medicine in Morocco. american-eurasian journal of sustainable agriculture, 2010, vol. 4, no. 1, p. 47–54. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

menthofuran (RF-00003924-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.2
Internal remarks:

Menthofuran

Composition #9: Derwich, E., Benziane, Z., Taouil, R., Senhaji, O., Touzani, M. Comparative essential oil composition of leaves of mentha rotundifolia and mentha pulegium a traditional herbal medicine in Morocco. american-eurasian journal of sustainable agriculture, 2010, vol. 4, no. 1, p. 47–54. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

piperitone oxide (RF-00011283-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.2
Internal remarks:

Piperitone oxide

Composition #10: Derwich, E., Benziane, Z., Boukir, A. Antibacterial activity and chemical composition of the leaf essential oil of mentha rotundifolia from Morocco. electronic journal of environmental, agricultural and food chemistry, 2010, vol. 9, no. 1, p. 19–28. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

menthofuran (RF-00003924-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.20
Internal remarks:

Menthofuran in leaf essential oil

Composition #11: Derwich, E., Benziane, Z., Boukir, A. Antibacterial activity and chemical composition of the leaf essential oil of mentha rotundifolia from Morocco. electronic journal of environmental, agricultural and food chemistry, 2010, vol. 9, no. 1, p. 19–28. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

Cis-Piperitone epoxide (RF-00011465-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.80
Internal remarks:

piperitone oxide in leaf essential oil

Composition #12: Derwich, E., Benziane, Z., Boukir, A. Antibacterial activity and chemical composition of the leaf essential oil of mentha rotundifolia from Morocco. electronic journal of environmental, agricultural and food chemistry, 2010, vol. 9, no. 1, p. 19–28. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.40
Internal remarks:

1,8-cineole in leaf essential oil

Composition #13: Derwich, E., Benziane, Z., Boukir, A. Antibacterial activity and chemical composition of the leaf essential oil of mentha rotundifolia from Morocco. electronic journal of environmental, agricultural and food chemistry, 2010, vol. 9, no. 1, p. 19–28. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.60
Internal remarks:

Myrcene in leaf essential oil

Composition #14: Baser, K. H. C., Kurkcuoglu, M., Demirci, B., Ozek, T., Tarimcilar, G. Essential oils of Mentha species from Marmara region of Turkey. JOURNAL OF ESSENTIAL OIL RESEARCH, 2012, vol. 24, no. 3, p. 265–272. DOI: 10.1080/10412905.2012.676775. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistilation
Substance:

Carvone (RF-0538-001-PPP)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

60
Internal remarks:

carvone in the aerial part essential oil

Composition #15: Baser, K. H. C., Kurkcuoglu, M., Demirci, B., Ozek, T., Tarimcilar, G. Essential oils of Mentha species from Marmara region of Turkey. JOURNAL OF ESSENTIAL OIL RESEARCH, 2012, vol. 24, no. 3, p. 265–272. DOI: 10.1080/10412905.2012.676775. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistilation
Substance:

Piperitenone oxide (RF-00008725-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

64-77
Internal remarks:

piperitenone oxide (epoxide) in the aerial part essential oil

Composition #16: Baser, K. H. C., Kurkcuoglu, M., Demirci, B., Ozek, T., Tarimcilar, G. Essential oils of Mentha species from Marmara region of Turkey. JOURNAL OF ESSENTIAL OIL RESEARCH, 2012, vol. 24, no. 3, p. 265–272. DOI: 10.1080/10412905.2012.676775. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistilation
Substance:

Dihydrocarvone (RF-00011286-PAR)
Additional substance description:
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

69
Internal remarks:

cis-dihydrocarvone in aerial part essential oil

Composition #17: Baser, K. H. C., Kurkcuoglu, M., Demirci, B., Ozek, T., Tarimcilar, G. Essential oils of Mentha species from Marmara region of Turkey. JOURNAL OF ESSENTIAL OIL RESEARCH, 2012, vol. 24, no. 3, p. 265–272. DOI: 10.1080/10412905.2012.676775. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistilation
Substance:

piperitone oxide (RF-00011283-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

75
Internal remarks:

piperitone oxide (epoxide) in the aerial part essential oil

Composition #18: Baser, K. H. C., Kurkcuoglu, M., Demirci, B., Ozek, T., Tarimcilar, G. Essential oils of Mentha species from Marmara region of Turkey. JOURNAL OF ESSENTIAL OIL RESEARCH, 2012, vol. 24, no. 3, p. 265–272. DOI: 10.1080/10412905.2012.676775. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3
Internal remarks:

Myrcene in aerial part essential oil