EFSA Compendium of Botanicals

Draft - work in progress

Mentha arvensis L.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 1587
Number of processed references:: 6

Compositions

#1: Carvone #2: Piperitone and piperitone oxide #3: Tannins #4: Eugenol #5: Menthone and isomenthone #6: Menthone and isomenthone #7: Isopulegone #8: Pulegone #9: Beta-Myrcene in essential oil #10: Carvone in essential oil #11: 3.8-cineole in essential oil

Endpoint Studies

#1: antiovulatory contraception for tribal women #2: male reproduction toxicity

Genotoxicity

Composition #1: Dutt, S. New Indian essential oils. indian soap journal, 1940, p. 248–255. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Carvone (RF-0538-001-PPP)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

80.8
Internal remarks:

Carvone

Composition #2: Bariya, Rashmi R., Pandya, Himanshu A. Screening, comparative analysis and evaluation of in vitro and in vivo produced Mentha arvensis L. international research journal of humanities, engineering pharmaceutical sciences, 2014, p. 92–96. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

p-Menth-1-en-3-one (RF-00009951-PAR)
Additional substance description:

Piperitone and piperitone oxide
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Piperitone and piperitone oxide

Composition #3: Bariya, Rashmi R., Pandya, Himanshu A. Screening, comparative analysis and evaluation of in vitro and in vivo produced Mentha arvensis L. international research journal of humanities, engineering pharmaceutical sciences, 2014, p. 92–96. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #4: Bariya, Rashmi R., Pandya, Himanshu A. Screening, comparative analysis and evaluation of in vitro and in vivo produced Mentha arvensis L. international research journal of humanities, engineering pharmaceutical sciences, 2014, p. 92–96. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Eugenol

Composition #5: Bariya, Rashmi R., Pandya, Himanshu A. Screening, comparative analysis and evaluation of in vitro and in vivo produced Mentha arvensis L. international research journal of humanities, engineering pharmaceutical sciences, 2014, p. 92–96. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

menthone (RF-00011280-PAR)
Additional substance description:

Menthone and isomenthone
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Menthone and isomenthone

Composition #6: Pedrazzani, A.S., Neto, A.O. The anaesthetic effect of camphor (Cinnamomum camphora), clove (Syzygium aromaticum) and mint (Mentha arvensis) essential oils on clown anemonefish, Amphiprion ocellaris (Cuvier 1830). aquaculture research, 2014 . DOI: 10.1111/are.12535. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

menthone (RF-00011280-PAR)
Additional substance description:

+ isomenthone (7.48%)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

20.25
Internal remarks:

Menthone and isomenthone

Composition #7: Pedrazzani, A.S., Neto, A.O. The anaesthetic effect of camphor (Cinnamomum camphora), clove (Syzygium aromaticum) and mint (Mentha arvensis) essential oils on clown anemonefish, Amphiprion ocellaris (Cuvier 1830). aquaculture research, 2014 . DOI: 10.1111/are.12535. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

unspecified
Substance:

trans-isopulegone (RF-00004088-PAR)
Additional substance description:

Isopulegone
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.81
Internal remarks:

Isopulegone

Composition #8: Pedrazzani, A.S., Neto, A.O. The anaesthetic effect of camphor (Cinnamomum camphora), clove (Syzygium aromaticum) and mint (Mentha arvensis) essential oils on clown anemonefish, Amphiprion ocellaris (Cuvier 1830). aquaculture research, 2014 . DOI: 10.1111/are.12535. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

unspecified
Substance:

(+)-pulegone (RF-00003398-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.39
Internal remarks:

Pulegone

Composition #9: Padalia, Rajendra C., Verma, Ram S., Chauhan, Amit., Sundaresan, Velusamy., Chanotiya, Chandan S. Essential oil composition of sixteen elite cultivars of Mentha from western Himalayan region, India . maejo international journal of science and technology, 2013, vol. 7, no. 1, p. 83–93. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

unspecified
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.5-0.6
Internal remarks:

Beta-Myrcene in essential oil

Composition #10: Padalia, Rajendra C., Verma, Ram S., Chauhan, Amit., Sundaresan, Velusamy., Chanotiya, Chandan S. Essential oil composition of sixteen elite cultivars of Mentha from western Himalayan region, India . maejo international journal of science and technology, 2013, vol. 7, no. 1, p. 83–93. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

unspecified
Substance:

Carvone (RF-0538-001-PPP)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0-01
Internal remarks:

Carvone in essential oil

Composition #11: Padalia, Rajendra C., Verma, Ram S., Chauhan, Amit., Sundaresan, Velusamy., Chanotiya, Chandan S. Essential oil composition of sixteen elite cultivars of Mentha from western Himalayan region, India . maejo international journal of science and technology, 2013, vol. 7, no. 1, p. 83–93. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

unspecified
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0-0.4
Internal remarks:

3.8-cineole in essential oil

Endpoint study #1: Rai, R., Nath, V. Some lesser known oral herbal contraceptives in folk claims as anti-fertility and fertility induced plants in Bastar region of Chhattisgarh. journal of natural remedies, 2005, vol. 5, no. 2, p. 153–159. .

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water
Type of toxicological test:

reproduction toxicity (CHD009TT)
Limit test:

Yes
Tested organism:

Human (as organism) (A056J)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Ovaries (TT047A)
Effect description:

contraception: antiovulatory
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

antiovulatory contraception for tribal women

Endpoint study #2: Sharma, N., Jocob, D. Antifertility investigation and toxicological screening of the petroleum ether extract of the leaves of Mentha arvensis L. in male albino mice . journal of ethnopharmacology, 2001, vol. 75, no. 1, p. 5–12. DOI: 10.1016/S0378-8741(00)00362-7. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

petroleum extracts
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

Male/Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

60.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

81
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per person per day (G232A)
Effect concentration:

10
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Testes (TT050A)
Effect description:

Decrease of the testis weight, epididymis, cauda epididymal sperm count, motility, viability and normal morphology of the spermatozoa; duration dependent reduction in the number of offspring
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

male reproduction toxicity