EFSA Compendium of Botanicals

Draft - work in progress

Melilotus albus Medik.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 215
Number of processed references:: 5

Compositions

#1: Coumarins in roots #2: Coumarins in shoot #3: Coumarins in leaves #4: p-coumaric acid glucoside in leaves #5: Coumarin in seed #6: Triterpene saponin in seed #7: Saponins in roots #8: Four new triterpene saponins of the oleanan series - melilotosides I, II, III,and nonglycosylated soyasapogenol B have been isolated from roots of Melilotus albus Medik.

Endpoint Studies

Genotoxicity

Composition #1: Reppel, L., Wagenbreth, D. Investigations on the content of coumarins and related substances in grafts between Melilotus albus and Trigonella foenum-graecum. flora (jena, 1818-1965), 1958, p. 212–227. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 70%
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

scopoletin,umbelliferon, herniarin and coumarin
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins in roots

Composition #2: Reppel, L., Wagenbreth, D. Investigations on the content of coumarins and related substances in grafts between Melilotus albus and Trigonella foenum-graecum. flora (jena, 1818-1965), 1958, p. 212–227. .

Language:

English (en)
Plant part:

Shoot (as part-nature) (A067T)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 70%
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

scopoletin,aesculetin,umbelliferon.herniarin, coumarin
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins in shoot

Composition #3: Kahnt, Guenter., Schoen, Walter J. Determination of coumarin and glucosides of cournaric acid in Melilotus albus leaves. angewandte botanik, 1962, p. 33–49. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins in leaves

Composition #4: Kahnt, Guenter., Schoen, Walter J. Determination of coumarin and glucosides of cournaric acid in Melilotus albus leaves. angewandte botanik, 1962, p. 33–49. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

p-coumaric acid (RF-00010717-PAR)
Additional substance description:

glucoside of the coumaric acid
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

p-coumaric acid glucoside in leaves

Composition #5: Blaim, Kazimierz., Przeszlakowska, M. Glycosides of Melilotus albus seeds. roczniki nauk rolniczych, seria a: produkcja roslinna, 1969, p. 75–81. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Coumarin (RF-00000370-TOX)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3
Internal remarks:

Coumarin in seed

Composition #6: Blaim, Kazimierz., Przeszlakowska, M. Glycosides of Melilotus albus seeds. roczniki nauk rolniczych, seria a: produkcja roslinna, 1969, p. 75–81. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Triterpene saponin in seed

Composition #7: Funck, E. Über das Vorkommen und den Nachweis eines Saponins in Melilotus albus. mikrochemie, 1938, vol. 24, no. 1, p. 262–264. DOI: 10.1007/BF02740521. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 70%
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins in roots

Composition #8: Khodakov, GV., Akimov, YA., Shashkov, AS., Kintia, PK., Grishkovets, VI., Waller, GR., Yamasaki, K. Triterpene and steroid saponins isolated from two melilotus species. saponins used in food and agriculture, 1996, vol. 405, p. 211–222. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

Four new triterpene saponins of the oleanan series - melilotosides I, II, III, IV and nonglycosylated soyasapogenol B
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Four new triterpene saponins of the oleanan series - melilotosides I, II, III,and nonglycosylated soyasapogenol B have been isolated from roots of Melilotus albus Medik.