EFSA Compendium of Botanicals

Draft - work in progress

Melaleuca ericifolia Sm.

Family:: Myrtaceae
Approval state:: Approved
Number of articles retrieved:: 76
Number of processed references:: 6

Compositions

#1: methyleugenol in leaf essential oil #2: 1,8-cineole #3: 20S-17beta,29-epoxy-28-norlupan-3beta-ol #4: Methyl eugenol in leaf volatile oil #5: 1,8-cineol in leaf essential oil #6: ericifolin (eugenol 5-O-galloylglucoside = in leaf) #7: 1,8-cineole in leaf essential oil

Endpoint Studies

Genotoxicity

Composition #1: Almeida Barbosa, Luiz Claudio., Silva, Cleber Jose., Teixeira, Robson Ricardo., Strozi Alves Meira, Renata Maria., Pinheiro, Antonio Lelis. Chemistry and Biological Activities of Essential Oils from Melaleuca L. Species. Agriculturae Conspectus Scientificus, 2013, vol. 78, no. 1, p. 11–23. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methyleugenol (RF-00003931-PAR)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

96.8
Internal remarks:

methyleugenol in leaf essential oil

Composition #2: Almeida Barbosa, Luiz Claudio., Silva, Cleber Jose., Teixeira, Robson Ricardo., Strozi Alves Meira, Renata Maria., Pinheiro, Antonio Lelis. Chemistry and Biological Activities of Essential Oils from Melaleuca L. Species. Agriculturae Conspectus Scientificus, 2013, vol. 78, no. 1, p. 11–23. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

34.5-79.5
Internal remarks:

1,8-cineole

Composition #3: Abdel Bar, Fatma M., Zaghloul, Ahmed M., Bachawal, Sunitha V., Sylvester, Paul W., Ahmad, Kadria F., El Sayed, Khalid A. Antiproliferative triterpenes from Melaleuca ericifolia.. Journal of natural products, 2008, vol. 71, no. 10, p. 1787–90. DOI: 10.1021/np800360a. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

epoxides (RF-00010829-PAR)
Additional substance description:

20S-17beta,29-epoxy-28-norlupan-3beta-ol
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

20S-17beta,29-epoxy-28-norlupan-3beta-ol

Composition #4: Abdel Bar, Fatma M., Khanfar, Mohammad A., Elnagar, Ahmed Y., Badria, Farid A., Zaghloul, Ahmed M., Ahmad, Kadria F., Sylvester, Paul W., El Sayed, Khalid A. Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors.. Bioorganic & medicinal chemistry, 2010, vol. 18, no. 2, p. 496–507. DOI: 10.1016/j.bmc.2009.12.019. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol, Methanol, water
Substance:

methyleugenol (RF-00003931-PAR)
Additional substance description:
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

96.8
Internal remarks:

Methyl eugenol in leaf volatile oil

Composition #5: Brophy, JJ., Doran, JC. Geographic variation in oil characteristics in Melaleuca ericifolia. journal of essential oil research, 2004, vol. 16, no. 1, p. 4–8. . [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

13.3-43.6
Internal remarks:

1,8-cineol in leaf essential oil

Composition #6: Hussein, S. A. M., Hashim, A. N. M., El-Sharawy, R. T., Seliem, M. A., Linscheid, M., Lindequist, U., Nawwar, M. A. M. Ericifolin: An eugenol 5-O-galloylglucoside and other phenolics from Melaleuca ericifolia . phytochemistry, 2007, vol. 68, no. 10, p. 1464–1470. DOI: 10.1016/j.phytochem.2007.03.010. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol/water extraction 3:1
Substance:

Eugenol (RF-00003807-PAR)
Additional substance description:

Ericifolin (eugenol 5-O-galloylglucoside)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

ericifolin (eugenol 5-O-galloylglucoside = in leaf)

Composition #7: Silva, Cleber J., Barbosa, Luiz C. A., Maltha, Ulia R. A., Pinheiro, Antonio L., Ismail, Fyaz M. D. Comparative study of the essential oils of seven Meialeuca (Myrtaceae) species grown in Brazil. FLAVOUR AND FRAGRANCE JOURNAL, 2007, vol. 22, no. 6, p. 474–478. DOI: 10.1002/ffj.1823. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

79.8
Internal remarks:

1,8-cineole in leaf essential oil