EFSA Compendium of Botanicals

Draft - work in progress

Matricaria matricarioides (Less.) Porter

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 106
Number of processed references:: 8

Compositions

#1: Coumarins in the aerial parts #2: Polycetylenes il live plant #3: Carvone in the aerial part #4: Coumarins in flowers #5: Myrcene #6: Herniarin (coumarin) in flower #7: Herniarin (coumarin) in leaves #8: Herniarin (coumarin) in stem #9: Herniarin (coumarin) in root #10: myrcene in the aerial part

Endpoint Studies

#1: bodyweight decrease: 38.5% #2: kidney relative weight increase: 25.3%

Genotoxicity

Composition #1: Loomis, Timothy F., Ma, Chaomei., Daneshtalab, Mohsen. Medicinal plants and herbs of Newfoundland. Part 1. Chemical constituents of the aerial part of pineapple weed (Matricaria matricarioides). Daru, 2004, vol. 12, no. 4, p. 131–135. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

Herniarin, Umbelliferone, 7-methoxy-3, 4-dihydrocoumarin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins in the aerial parts

Composition #2: Bohlmann, Ferdinand., Herbst, Peter., Arndt, Christian., Schoenowsky, Hubert., Gleinig, Harald. Polyacetylene compounds. XXXIV. A new type of polyacetylene compounds from various representatives of the tribe Anthemideae. chemische berichte, 1961, p. 3193–3216. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Et2O and ptroleum ether
Substance:

polyacetylene derivatives polyacetylene derivatives (RF-00004332-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Polycetylenes il live plant

Composition #3: Lawrence, Brian M., Terhune, Stuart J., Hogg, James W. Volatile constituents of Matricaria matricarioides. Phytochemistry (Elsevier), 1971 . .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

Steam distilation
Substance:

Carvone (RF-0538-001-PPP)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.4
Internal remarks:

Carvone in the aerial part

Composition #4: Kirs, L. Effect of surfactants on the extraction of flowers of Matricaria chamomilla L. and Matricaria matricarioides (Less.) Port. tartu riikliku ulikooli toimetised, 1980, p. 33–40. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Tween 80
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins in flowers

Composition #5: Orav, A., Kailas, T., Kann, J. Volatile constituents of Matricaria matricarioides (Less.) port.. Journal of Essential Oil Research, 1999, vol. 11, no. 2, p. 243–245. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hexane
Substance:

myrcene (RF-00003503-PAR)
Additional substance description:

from fresh and dried plant
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

23.0-50.6
Internal remarks:

Myrcene

Composition #6: Ma, Chao-Mei., Winsor, Linda., Daneshtalab, Mohsen. Quantification of spiroether isomers and herniarin of different parts of Matricaria matricarioides and flowers of Chamaemelum nobile. PHYTOCHEMICAL ANALYSIS, 2007, vol. 18, no. 1, p. 42–49. DOI: 10.1002/pca.950. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

herniarin (RF-00010991-PAR)
Analytical method code:

HPLC-UV (F021A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.39
Internal remarks:

Herniarin (coumarin) in flower

Composition #7: Ma, Chao-Mei., Winsor, Linda., Daneshtalab, Mohsen. Quantification of spiroether isomers and herniarin of different parts of Matricaria matricarioides and flowers of Chamaemelum nobile. PHYTOCHEMICAL ANALYSIS, 2007, vol. 18, no. 1, p. 42–49. DOI: 10.1002/pca.950. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

herniarin (RF-00010991-PAR)
Analytical method code:

HPLC-UV (F021A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.94
Internal remarks:

Herniarin (coumarin) in leaves

Composition #8: Ma, Chao-Mei., Winsor, Linda., Daneshtalab, Mohsen. Quantification of spiroether isomers and herniarin of different parts of Matricaria matricarioides and flowers of Chamaemelum nobile. PHYTOCHEMICAL ANALYSIS, 2007, vol. 18, no. 1, p. 42–49. DOI: 10.1002/pca.950. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

herniarin (RF-00010991-PAR)
Analytical method code:

HPLC-UV (F021A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.14
Internal remarks:

Herniarin (coumarin) in stem

Composition #9: Ma, Chao-Mei., Winsor, Linda., Daneshtalab, Mohsen. Quantification of spiroether isomers and herniarin of different parts of Matricaria matricarioides and flowers of Chamaemelum nobile. PHYTOCHEMICAL ANALYSIS, 2007, vol. 18, no. 1, p. 42–49. DOI: 10.1002/pca.950. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

herniarin (RF-00010991-PAR)
Analytical method code:

HPLC-UV (F021A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.02
Internal remarks:

Herniarin (coumarin) in root

Composition #10: LAWRENCE, BM., TERHUNE, SJ., HOGG, JW. VOLATILE CONSTITUENTS OF MATRICARIA-MATRICARIOIDES. phytochemistry, 1971, vol. 10, no. 11, p. 2827–&. DOI: 10.1016/S0031-9422(00)97295-9. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

myrcene (RF-00003503-PAR)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

15.6
Internal remarks:

myrcene in the aerial part

Endpoint study #1: Bergeron, Jean Marie., Goulet, Marie. Study on the phytoestrogenic and phytotoxic effects of open-land plants on the laboratory mouse. canadian journal of zoology, 1980, p. 1575–1581. .

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Drying (dehydration) (A07KG)
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

28.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

10
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Grams per day (G233A)
Effect concentration:

1.79
Critical effect:

DEVELOPMENTAL (TOX07A)
Target tissue:

Muscle, Skeletal (TT055A)
Effect description:

bodyweight decrease: 38.5%
Effect or parameter linked to the endpoint:

body weight (CHD005BE)
Internal remarks:

bodyweight decrease: 38.5%

Endpoint study #2: Bergeron, Jean Marie., Goulet, Marie. Study on the phytoestrogenic and phytotoxic effects of open-land plants on the laboratory mouse. canadian journal of zoology, 1980, p. 1575–1581. .

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Drying (dehydration) (A07KG)
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

28.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

10
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Grams per day (G233A)
Effect concentration:

1.79
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

kidney relative weight increase: 25.3%
Effect or parameter linked to the endpoint:

organ weights (CHD012BE)
Internal remarks:

kidney relative weight increase: 25.3%