EFSA Compendium of Botanicals

Draft - work in progress

Mammey apple (as plant) // Mammea americana L.

Family:: Calophyllaceae
Approval state:: Approved
Number of articles retrieved:: 231
Number of processed references:: 3

Compositions

#1: Mammein #2: mammea E/BB #3: Hydroxycoumarins (Mammea F/BB, mammea F/BA, and mammea C/AA)

Endpoint Studies

Genotoxicity

Composition #1: Finnegan, R.A., Morris, M.P., Djerassi, C. Naturally occurring oxygen heterocyclics. X. 4-Phenyl-5,7-dihydroxy-6-isovaleryl-8-isopentenylcoumarin. journal of organic chemistry, 1961, vol. 26, no. 4, p. 1180–1184. .

Language:

English (en)
Plant part:

Fruit peel (as part-nature) (A067G)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

Mammein
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Mammein

Composition #2: Du, L., Mahdi, F., Jekabsons, M.B., Nagle, D.G., Zhou, Y.-D. Mammea E/BB, an isoprenylated dihydroxycoumarin protonophore that potently uncouples mitochondrial electron transport, disrupts hypoxic signaling in tumor cells. Journal of Natural Products, 2010, vol. 73, no. 11, p. 1868–1872. DOI: 10.1021/np100501n. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2Cl2-MeOH (1:1)
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

mammea E/BB in stem bark
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

HPLC + NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

mammea E/BB

Composition #3: Du, Lin., Mandi, Fakhri., Jekabsons, Mika B., Nagle, Dale G., Zhou, Yu-Dong. Natural and Semisynthetic Mammea-Type Isoprenylated Dihydroxycoumarins Uncouple Cellular Respiration. JOURNAL OF NATURAL PRODUCTS, 2011, vol. 74, no. 2, p. 240–248. DOI: 10.1021/np100762s. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2Cl2/MeOH (1:1)
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

Mammea F/BB, mammea F/BA, and mammea C/AA in stem bark
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR + HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Hydroxycoumarins (Mammea F/BB, mammea F/BA, and mammea C/AA)