Composition #1: Siddiqui, B.S., Khan, S., Nadeem Kardar, M. A new isoflavone from the fruits of Madhuca latifolia. Natural Product Research, 2010, vol. 24, no. 1, p. 76–80. DOI: 10.1080/14786410902830100.
[DOI link]
Language:
English (en)
Plant part:
Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:
Solvent extraction (A0BZR)
Additional extraction description:
Methanol
Substance:
isoflavones (RF-00004359-PAR)
Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:
C and H NMR, EIMS, HMBC, HMQC, HRMS
Yes/No Qualitative:
Positive/Present (POS)
Result type:
Qualitative Value (Binary) (BIN)
Internal remarks:
Isoflavones
Composition #2: Cherian K M., Gandhi V M., Mulky M J. Toxicological evaluation of mowrah (Madhuca latifolia Macbride) seed meal. indian journal of experimental biology, 1996, p. 61–65. .
Language:
English (en)
Plant part:
Seed (as part-nature) (A066P)
Additional extraction description:
unspecified
Substance:
Saponins (RF-00004333-PAR)
Analytical method code:
Unspecified (F598A)
Result unit:
Percent (G138A)
Result type:
Numerical Value (VAL)
Value (concentration, content):
7.1
Internal remarks:
Saponins
Composition #3: SINGH, A., SINGH, IS. CHEMICAL EVALUATION OF MAHUA (MADHUCA-INDICA) SEED. food chemistry, 1991, vol. 40, no. 2, p. 221–228. DOI: 10.1016/0308-8146(91)90106-X.
[DOI link]
Language:
English (en)
Plant part:
Seed (as part-nature) (A066P)
Extraction/Preparation method:
Solvent extraction (A0BZR)
Additional extraction description:
petroleum ether
Substance:
Saponins (RF-00004333-PAR)
Analytical method code:
Gaschromatography (GC) (F037A)
Result unit:
Percent (G138A)
Result type:
Numerical Value (VAL)
Value (concentration, content):
2.5-9.8
Internal remarks:
saponins
Endpoint study
#1: Rukmini, C. Reproductive toxicology and nutritional studies on mahua oil (Madhuca latifolia). Food and Chemical Toxicology, 1990, vol. 28, no. 9, p. 601–605. DOI: 10.1016/0278-6915(90)90166-K.
[DOI link]
Study relevance:
Human health
Plant part:
Seed (as part-nature) (A066P)
Additional plant/substance description:
oil
Type of toxicological test:
other (CHD008TT)
Tested organism:
Rat (as animal) (A0CNV)
Sex:
Male/Female
Route of exposure:
ORAL: FEED (OECD2230PL)
Exposure duration:
16.0
Unit of exposure duration:
Week (G205A)
Number of organisms dosed:
30
Control groups used:
yes
Endpoint measured:
Concentration level (CHD013EP)
Concentration unit:
Percent (G138A)
Effect concentration:
10
Critical effect:
REPRODUCTIVE (TOX05A)
Target tissue:
urogenital: Testes (TT050A)
Effect description:
In F1b adults, exhibited bilateral testicular atrophy with extensive degenerative changes in the seminiferous tubules (reversible)
Effect or parameter linked to the endpoint:
histopathology neoplastic (CHD024BE)
Internal remarks:
Multigeneration studies revealed adverse effects on reproductive toxicology
Endpoint study
#2: Cherian K M., Gandhi V M., Mulky M J. Toxicological evaluation of mowrah (Madhuca latifolia Macbride) seed meal. indian journal of experimental biology, 1996, p. 61–65. .
Study relevance:
Human health
Substance:
Saponins (RF-00004333-PAR)
Plant part:
Seed (as part-nature) (A066P)
Additional plant/substance description:
mowrah saponins
Type of toxicological test:
short-term toxicity (CHD017TT)
Tested organism:
Rat (as animal) (A0CNV)
Strain of test organism:
Wistar (CHD013ST)
Sex:
Male/Female
Route of exposure:
ORAL: FEED (OECD2230PL)
Exposure duration:
28.0
Unit of exposure duration:
Day (G134A)
Number of organisms dosed:
12
Endpoint measured:
Concentration level (CHD013EP)
Concentration unit:
Percent (G138A)
Effect concentration:
10-40
Critical effect:
Digestive (TOX18A)
Target tissue:
Digestive (TT002A)
Effect description:
gradation of damage from slight erosion of the tip of villi of intestinal mucous membrane to complete necrosis and destruction of it, with increasing amounts of mowrah seed meal in diets
Effect or parameter linked to the endpoint:
mortality (CHD010BE)
Internal remarks:
marked inhibition of feed intake leading to mortality
