EFSA Compendium of Botanicals

Draft - work in progress

Lycopodium japonicum Thunb.

Family:: Lycopodiaceae
Approval state:: Approved
Number of articles retrieved:: 85
Number of processed references:: 6

Compositions

#1: Physcion #2: Alkaloids (total) #3: Lycopodine-type alkaloids #4: Miyoshianine A and C #5: Alkaloids (fawcettimine-type) #6: Lycodine-type alkaloids

Endpoint Studies

Genotoxicity

Composition #1: Cai, X., Pan, D., Chen, Y., Wu, W., Liu, X. The isolation and identification of the anthraquinones from Lycopodium japonicum L. and Lycopodium obscurum L. acta academiae medicinae shanghai, 1991, vol. 18, no. 5, p. 383–385. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

physcion (RF-00003993-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Physcion

Composition #2: Yang, Z., Zhang, D., Ren, J., Yang, M., Li, S. Acetylcholinesterase inhibitory activity of the total alkaloid from traditional Chinese herbal medicine for treating Alzheimer's disease. medicinal chemistry research, 2012, vol. 21, no. 6, p. 734–738. DOI: 10.1007/s00044-011-9582-8. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol (95%)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Total alkaloids (% dry weight basis)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.459
Internal remarks:

Alkaloids (total)

Composition #3: He, Juan., Wu, Xing-De., Liu, Fei., Liu, Yu-Cheng., Peng, Li-Yan., Zhao, Yu., Cheng, Xiao., Luo, Huai-Rong., Zhao, Qin-Shi. Lycopodine-Type Alkaloids from Lycopodium japonicum.. Natural products and bioprospecting, 2014, vol. 4, no. 4, p. 213–9. DOI: 10.1007/s13659-014-0027-1. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

lycopodine (RF-00003475-PAR)
Additional substance description:

lycopodine-type alkaloids (4a-hydroxyanhydrolycodoline, 4a,6a-dihydroxyanhydrolycodoline, 6-epi-8b-acetoxylycoclavine)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

chromatographic separation, melting point, optical rotations, IR, NMR, MS, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lycopodine-type alkaloids

Composition #4: Sun, Yun., Yan, Jian., Meng, Hao., He, Chun-Lin., Yi, Ping., Qiao, Ying., Qiu, Ming-Hua. A New Alkaloid from Lycopodium japonicum THUNB.. HELVETICA CHIMICA ACTA, 2008, vol. 91, no. 11, p. 2107–2109. DOI: 10.1002/hlca.200890225. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

miyoshianine A and C
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Miyoshianine A and C

Composition #5: Wang, Xiao-Jing., Liu, Yun-Bao., Li, Li., Yu, Shi-Shan., Lv, Hai-Ning., Ma, Shuang-Gang., Bao, Xiu-Qi., Zhang, Dan., Qu, Jing., Li, Yong. Lycojaponicumins D and E: Two New Alkaloids from Lycopodium japonicum. ORGANIC LETTERS, 2012, vol. 14, no. 22, p. 5688–5691. DOI: 10.1021/ol302701y. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Fawcettimine-type alkaloids: lycojaponicumin D & E
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, IR, NMR, MS, X-Ray
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids (fawcettimine-type)

Composition #6: Wu, Jichun., Wang, Huanqin., Ma, Yanfang., Jiang, Jinhe., Zhan, Rui., Chen, Yegao. Isolation of a new lycodine alkaloid from Lycopodium japonicum. NATURAL PRODUCT RESEARCH, 2015, vol. 29, no. 8, p. 735–738. DOI: 10.1080/14786419.2014.984184. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

lycodine (RF-00003474-PAR)
Additional substance description:

Lycodine-type alkaloids: N-methylhydroxypropyllycodine, N-methyllycodine, huperzinine , b-obscurine , a-obscurine, des-N-methyl-a-obscurine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

chromatographic separation, optical rotation, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lycodine-type alkaloids