EFSA Compendium of Botanicals

Draft - work in progress

Loeselia mexicana (Lam.) Brand // Loeselia coccinea (Cav.) G. Don

Family:: Polemoniaceae
Approval state:: Approved
Number of articles retrieved:: 24
Number of processed references:: 3

Compositions

#1: sesquiterpene lactones #2: umbelliferone #3: scopoletin #4: daphnoretin

Endpoint Studies

Genotoxicity

Composition #1: Perez, G Salud., Perez, G Cuauhtemoc., Zavala, M A. A study of the antidiarrheal properties of Loeselia mexicana on mice and rats.. phytopharmacology, 2005, vol. 12, no. 9, p. 670–4. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol, water
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

phytochemical analysis
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sesquiterpene lactones

Composition #2: Navarro-Garcia, Victor M., Herrera-Ruiz, Maribel., Rojas, Gabriela., Zepeda, L. Gerardo. Coumarin derivatives from Loeselia mexicana. Determination of the anxiolytic effect of daphnoretin on elevated plus-maze. JOURNAL OF THE MEXICAN CHEMICAL SOCIETY, 2007, vol. 51, no. 4, p. 193–197. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

60% ethanol
Substance:

umbelliferone (RF-00004096-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, HRFABMS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

umbelliferone

Composition #3: Navarro-Garcia, Victor M., Herrera-Ruiz, Maribel., Rojas, Gabriela., Zepeda, L. Gerardo. Coumarin derivatives from Loeselia mexicana. Determination of the anxiolytic effect of daphnoretin on elevated plus-maze. JOURNAL OF THE MEXICAN CHEMICAL SOCIETY, 2007, vol. 51, no. 4, p. 193–197. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

60% ethanol
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, HRFABMS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

scopoletin

Composition #4: Herrera-Ruiz, Maribel., Gonzalez-Carranza, Adolfo., Zamilpa, Alejandro., Jimenez-Ferrer, Enrique., Huerta-Reyes, Maira., Navarro-Garcia, Victor M. The standardized extract of Loeselia mexicana possesses anxiolytic activity through the gamma-amino butyric acid mechanism. JOURNAL OF ETHNOPHARMACOLOGY, 2011, vol. 138, no. 2, p. 261–267. DOI: 10.1016/j.jep.2011.09.010. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

daphnoretin (RF-00004252-PAR)
Additional substance description:

1.57% in methanolic extract (which was 15% of the plant material)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.57
Internal remarks:

daphnoretin