EFSA Compendium of Botanicals

Draft - work in progress

Liriodendron tulipifera L.

Family:: Magnoliaceae
Approval state:: Approved
Number of articles retrieved:: 1807
Number of processed references:: 8

Compositions

#1: costunolide #2: Aporphine alkaloids #3: Lignans #4: Isoquinoline alkaloids #5: Aporphine alkaloids #6: Lirinine and derivatives #7: Tannins #8: Lipiferolide #9: (−)-syringaresinol #10: Lignans #11: Lignans

Endpoint Studies

Genotoxicity

Composition #1: Doskotch, Raymond W., El-Feraly, Farouk S. Antitumor agents. II. Tulipinolide, a new germacranolide sesquiterpene, and costunolide. Two cytotoxic substances from Liriodendron tulipifera L. journal of pharmaceutical sciences, 1969, p. 877–880. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extract of root bark
Substance:

costunolide (RF-00003753-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

costunolide

Composition #2: Chen, Chen-Loung., Chang, Hou-Min., Cowling, Ellis B. The chemistry of Liriodendron tulipifera L. Part I. Aporphine alkaloids and lignans in heartwood of Liriodendron tulipifera. phytochemistry (elsevier), 1976, p. 547–550. .

Language:

English (en)
Plant part:

Wood (as part-nature) (A166P)
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Additional substance description:

glaucine, dehydroglaucine, asimilobine, N-acetylnornuciferine, norushinsunine, liriodenine, O-methylatheroline
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aporphine alkaloids

Composition #3: Chen, Chen-Loung., Chang, Hou-Min., Cowling, Ellis B. The chemistry of Liriodendron tulipifera L. Part I. Aporphine alkaloids and lignans in heartwood of Liriodendron tulipifera. phytochemistry (elsevier), 1976, p. 547–550. .

Language:

English (en)
Plant part:

Wood (as part-nature) (A166P)
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

syringaresinol, (+)-syringaresinol dimethyl ether, and syringaldehyde
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans

Composition #4: Chen, Chen-Loung., Chang, Hou-Min., Cowling, Ellis B. The chemistry of Liriodendron tulipifera L. Part I. Aporphine alkaloids and lignans in heartwood of Liriodendron tulipifera. phytochemistry (elsevier), 1976, p. 547–550. .

Language:

English (en)
Plant part:

Wood (as part-nature) (A166P)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

1-benzyltetrahydroisoquinoline alkaloids
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids

Composition #5: Hufford, Charles D. Four new N-acetylnoraporphine alkaloids from Liriodendron tulipifera. Phytochemistry (Elsevier), 1976, p. 1169–1171. .

Language:

English (en)
Plant part:

Wood (as part-nature) (A166P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Additional substance description:

(-)-N-acetylanonaine; (-)-N-acetylnornuciferine; (-)-N-acetylasimilobine; (-)-tuliferoline
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aporphine alkaloids

Composition #6: Ziyaev, R., Ikramov, K., Kadyrov, Kh. A., Abdusamatov, A. Alkaloids of Liriodendron tulipifera. Khimiya Prirodnykh Soedinenii, 1991, p. 587–588. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

benzene-methanol
Substance:

Lirinine (RF-00011232-PAR)
Additional substance description:

Lirinine and derivatives
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lirinine and derivatives

Composition #7: Berenbaum, M.R. Effects of tannins on growth and digestion in two species of papilionids. Entomologia Experimentalis et Applicata, 1983, vol. 34, no. 3, p. 245–250. DOI: 10.1007/BF00186920. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Acetone (80%)
Substance:

Tannins (RF-00004337-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #8: Moon, Mi Kyeong., Oh, Hyun Mi., Kwon, Byoung-Mog., Baek, Nam-In., Kim, Sung-Hoon., Kim, Ju Sin., Kim, Dae Keun. Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera. ARCHIVES OF PHARMACAL RESEARCH, 2007, vol. 30, no. 3, p. 299–302. DOI: 10.1007/BF02977609. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Lipiferolide (RF-00010895-PAR)
Additional substance description:

Lipiferolide
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lipiferolide

Composition #9: Jeong, Eun Ju., Kim, Na-Hyun., Heo, Jeong-Doo., Lee, Ki Yong., Rho, Jung-Rae., Kim, Young Choong., Sung, Sang Hyun. Antifibrotic Compounds from Liriodendron tulipifera Attenuating HSC-T6 Proliferation and TNF-alpha Production in RAW264.7 Cells. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2015, vol. 38, no. 2, p. 228–234. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH(80%)
Substance:

syringaresinol (RF-00011386-PAR)
Additional substance description:

(−)-syringaresinol
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

(−)-syringaresinol

Composition #10: Jeong, Eun Ju., Kim, Na-Hyun., Heo, Jeong-Doo., Lee, Ki Yong., Rho, Jung-Rae., Kim, Young Choong., Sung, Sang Hyun. Antifibrotic Compounds from Liriodendron tulipifera Attenuating HSC-T6 Proliferation and TNF-alpha Production in RAW264.7 Cells. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2015, vol. 38, no. 2, p. 228–234. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH(80%)
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

tanegool
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans

Composition #11: Yang, Dong-Ting., Lin, Sen-Sen., Chen, Jin-Hui., Yuan, Sheng-Tao., Shi, Ji-Sen., Wang, Jun-Song., Jia, Ai-Qun. (+)- and (-)-liriodenol, a pair of novel enantiomeric lignans from Liriodendron hybrid. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, vol. 25, no. 9, p. 1976–1978. DOI: 10.1016/j.bmcl.2015.03.015. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (95%)
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

(±)-liriodenol
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans