EFSA Compendium of Botanicals

Draft - work in progress

Lindera aggregata (Sims) Kosterm. // Lindera strychnifolia (Siebold & Zucc.) Fern.-Vill.

Family:: Lauraceae
Approval state:: Approved
Number of articles retrieved:: 391
Number of processed references:: 5

Compositions

#1: Launobine #2: Tannins #3: Sesquiterpene lactones #4: Isoquinoline alkaloids #5: Aporphine alkaloids #6: norisoboldine

Endpoint Studies

Genotoxicity

Composition #1: Tomita, Masao., Sawada, Tokunosuke., Kozuka, Mutsuo., Hamano, Daisuke., Yoshimura, Katsumi. Alkaloids of Lindera strychnifolia and Lindera umbellata. yakugaku zasshi, 1969, p. 737–740. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol (hot)
Substance:

Launobine (RF-00011230-PAR)
Additional substance description:

amount of crude amount extracted (300 mg/10 kg dried roots)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR - IR
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

30
Internal remarks:

Launobine

Composition #2: Zhang, Chao-Feng., Chou, Gui-Xin., Sun, Qi-Shi., Wang, Zheng-Tao., Hattori, Masao. Tannins from the stems of Lindera aggregata I. zhongguo tianran yaowu, 2003, p. 204–206. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

60% acetone
Substance:

Tannins (RF-00004337-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #3: Yan, Lili., Wang, Jinfang., Li, Qiuyue., Shi, Yue. Study of chemical components of Lindera aggregata. zhongguo yaoye, 2013, p. 16–17. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

Linderane, isolinderalactone, linderalactone
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene lactones

Composition #4: Gan, Li-She., Yao, Wei., Mo, Jian-Xia., Zhou, Chang-Xin. Alkaloids from Lindera aggregata. natural product communications, 2009, vol. 4, no. 1, p. 43–46. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

(+)-reticuline, (-)-pronuciferine, and pallidine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids

Composition #5: Gan, Li-She., Yao, Wei., Mo, Jian-Xia., Zhou, Chang-Xin. Alkaloids from Lindera aggregata. natural product communications, 2009, vol. 4, no. 1, p. 43–46. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Additional substance description:

(+)-norboldine acetate, (+)-norboldine, (+)-boldine, (+)-laurotetanine, (+)-N-methyllaurotetanine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aporphine alkaloids

Composition #6: Luo, Yubin., Liu, Mei., Dai, Yue., Yao, Xiujuan., Xia, Yufeng., Chou, Guixin., Wang, Zhengtao. Norisoboldine Inhibits the Production of Pro-inflammatory Cytokines in Lipopolysaccharide-Stimulated RAW 264.7 Cells by Down-Regulating the Activation of MAPKs but Not NF-kappa B . inflammation, 2010, vol. 33, no. 6, p. 389–397. DOI: 10.1007/s10753-010-9197-0. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

unspecified
Substance:

norisoboldine (RF-00003953-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

UV, IR, MS, 1 H- and 13C-NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

norisoboldine