EFSA Compendium of Botanicals

Draft - work in progress

Lilium lancifolium Thunb.

Family:: Liliaceae
Approval state:: Approved
Number of articles retrieved:: 223
Number of processed references:: 6

Compositions

#1: Medioresinol (lignan) in bulb #2: Syringaresinol (lignan) in bulb #3: Pinoresinol (lignan) in bulb #4: Secoisolaricinisol (lignan) in bulb #5: Dioscin (saponin) in bulb #6: p-coumaric acid (phenylpropanoid) #7: Berberine (alkaloid) in leaves

Endpoint Studies

#1: Trypsin inhibitor #2: nephrotoxicity in cats

Genotoxicity

Composition #1: Penalvo, Jose L., Adlercreutz, Herman., Uehara, Mariko., Ristimaki, Anna., Watanabe, Shaw. Lignan Content of Selected Foods from Japan. journal of agricultural and food chemistry, 2008, p. 401–409. .

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

medioresinol (RF-00011065-PAR)
Additional substance description:

raw or boiled
Analytical method code:

GC-MS (F046A)
Result unit:

Microgram/100 gram (G046A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2-10
Internal remarks:

Medioresinol (lignan) in bulb

Composition #2: Penalvo, Jose L., Adlercreutz, Herman., Uehara, Mariko., Ristimaki, Anna., Watanabe, Shaw. Lignan Content of Selected Foods from Japan. journal of agricultural and food chemistry, 2008, p. 401–409. .

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

syringaresinol (RF-00011386-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Microgram/100 gram (G046A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

40-415
Internal remarks:

Syringaresinol (lignan) in bulb

Composition #3: Penalvo, Jose L., Adlercreutz, Herman., Uehara, Mariko., Ristimaki, Anna., Watanabe, Shaw. Lignan Content of Selected Foods from Japan. journal of agricultural and food chemistry, 2008, p. 401–409. .

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Pinoresinol (RF-00011088-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Microgram/100 gram (G046A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

58-191
Internal remarks:

Pinoresinol (lignan) in bulb

Composition #4: Penalvo, Jose L., Adlercreutz, Herman., Uehara, Mariko., Ristimaki, Anna., Watanabe, Shaw. Lignan Content of Selected Foods from Japan. journal of agricultural and food chemistry, 2008, p. 401–409. .

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

secoisolarisiresinol (RF-00000390-NTR)
Analytical method code:

GC-MS (F046A)
Result unit:

Microgram/100 gram (G046A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.0
Internal remarks:

Secoisolaricinisol (lignan) in bulb

Composition #5: Huang, Jiang-jian., Gao, Ying., Li, Wei-ming., Ye, Xue-lan. Quantitative determination of dioscin in Bulbus Lilii by HPLC- ELSD. zhongguo shiyan fangjixue zazhi, 2011, p. 110–112. .

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

dioscin (RF-00003782-PAR)
Analytical method code:

HPLC-ELSD (F327A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Dioscin (saponin) in bulb

Composition #6: 박태영., 서경순., 최성규., Yun, KyeongWon. Chemical Constituents of Bulb of Lilium lancifolium Thunberg and Lilium tsingtauense Gilg . korean journal of plant reources., 2014, vol. 27, no. 2, p. 125–132. DOI: 10.7732/kjpr.2014.27.2.125. [DOI link]

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, ether, ethyl acetate, water
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.25-1.93
Internal remarks:

p-coumaric acid (phenylpropanoid)

Composition #7: Hu, Wen-yan., Duan, Jin-ao., Qian, Da-wei., Wang, Da-wei. Studies on chemical constituents in fresh fleshy scaleleaf of Lilium lancifolium . . zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2007, vol. 32, no. 16, p. 1656–9. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Berberine (alkaloid) in leaves

Endpoint study #1: Asao, Toshio., Horiguchi, Miwa., Terada, Chikako., Takahashi, Kyoko. Purification and Characterization of a Trypsin Inhibitor from Lily Bulb (Lilium lancifolium) . journal of the japanese society for food science and technology-nippon shokuhin kagaku kogaku kaishi, 1998, vol. 45, no. 11, p. 663–670. .

Study relevance:

Human health
Plant part:

Bulb / clove (as part-nature) (A067A)
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

trypsin inhibitor.
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Trypsin inhibitor

Endpoint study #2: Berg, Rebecca I. M., Francey, Thierry., Segev, Gilad. Resolution of acute kidney injury in a cat after lily (Lilium lancifiolium) intoxication. JOURNAL OF VETERINARY INTERNAL MEDICINE, 2007, vol. 21, no. 4, p. 857–859. DOI: 10.1892/0891-6640(2007)21[857:ROAKII]2.0.CO;2. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Flower (as part-nature) (A067B)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Cat (as animal) (A0CNM)
Sex:

Male
Route of exposure:

OTHER (OECD0PL)
Number of organisms dosed:

1
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

laterally thickened and hyperechoic renal cortices. moderate amount of anechoic fluid in the peritoneal cavity
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

nephrotoxicity in cats