EFSA Compendium of Botanicals

Draft - work in progress

Ligusticum porteri J.M.Coult. & Rose

Family:: Apiaceae (Umbelifferae)
Approval state:: Approved
Number of articles retrieved:: 126
Number of processed references:: 5

Compositions

#1: Coniferyl ferulate (phenylpropanoid) #2: Falcarindiol (polyacetylene) #3: (Z)-ligustilide and derivatives #4: (Z)-3-Butylidenephthalide #5: Myristicin #6: Alkaloids in root #7: Tannins in root #8: Z-ligustilide in root #9: (Z)-3-butylidenephthalide in root #10: Z-ligustilide in root #11: Tokinolide B

Endpoint Studies

#1: alpha-glucosidase inhibition by 3-butylidenephthalide

Genotoxicity

Composition #1: Zschocke, S., Liu, JH., Stuppner, H., Bauer, R. Comparative study of roots of Angelica sinensis and related umbelliferous drugs by thin layer chromatography, high-performance liquid chromatography, and liquid chromatography mass spectrometry. PHYTOCHEMICAL ANALYSIS, 1998, vol. 9, no. 6, p. 283–290. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

DCM, Hexane
Substance:

phenylpropanoids (RF-00004367-PAR)
Additional substance description:

Coniferyl ferulate
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coniferyl ferulate (phenylpropanoid)

Composition #2: Zschocke, S., Liu, JH., Stuppner, H., Bauer, R. Comparative study of roots of Angelica sinensis and related umbelliferous drugs by thin layer chromatography, high-performance liquid chromatography, and liquid chromatography mass spectrometry. PHYTOCHEMICAL ANALYSIS, 1998, vol. 9, no. 6, p. 283–290. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

DCM, Hexane
Substance:

falcarindiol (RF-00003811-PAR)
Additional substance description:
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Falcarindiol (polyacetylene)

Composition #3: Brindis, Fernando., Rodriguez, Rogelio., Bye, Robert., Gonzalez-Andrade, Martin., Mata, Rachel. (Z)-3-Butylidenephthalide from Ligusticum porteri, an alpha-Glucosidase Inhibitor. JOURNAL OF NATURAL PRODUCTS, 2011, vol. 74, no. 3, p. 314–320. DOI: 10.1021/np100447a. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2Cl2-MeOH
Substance:

ligustilide (RF-00003900-PAR)
Additional substance description:

ligustilide and derivatives
Analytical method code:

HPLC-UV (F021A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

(Z)-ligustilide and derivatives

Composition #4: Brindis, Fernando., Rodriguez, Rogelio., Bye, Robert., Gonzalez-Andrade, Martin., Mata, Rachel. (Z)-3-Butylidenephthalide from Ligusticum porteri, an alpha-Glucosidase Inhibitor. JOURNAL OF NATURAL PRODUCTS, 2011, vol. 74, no. 3, p. 314–320. DOI: 10.1021/np100447a. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2Cl2-MeOH
Substance:

3-Butylidenephthalide 3-Butylidenephthalide (RF-00001798-PAR)
Additional substance description:
Analytical method code:

HPLC-UV (F021A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

(Z)-3-Butylidenephthalide

Composition #5: Brindis, Fernando., Rodriguez, Rogelio., Bye, Robert., Gonzalez-Andrade, Martin., Mata, Rachel. (Z)-3-Butylidenephthalide from Ligusticum porteri, an alpha-Glucosidase Inhibitor. JOURNAL OF NATURAL PRODUCTS, 2011, vol. 74, no. 3, p. 314–320. DOI: 10.1021/np100447a. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2Cl2-MeOH
Substance:

myristicin (RF-00003941-PAR)
Analytical method code:

HPLC-UV (F021A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Myristicin

Composition #6: Castaneda Sortibran, America., Ordaz Tellez, Maria Guadalupe., Ocotero, Veronica Munoz., Antonio Carballo-Ontiveros, Marco., Garcia, Angelica Mendez., Jimenez Valdes, Rocio Jimena., Romero Gutierrez, Elizabeth., Rodriguez-Arnaiz, Rosario. Chronic Toxicity, Genotoxic Assay, and Phytochemical Analysis of Four Traditional Medicinal Plants. JOURNAL OF MEDICINAL FOOD, 2011, vol. 14, no. 9, p. 1018–1022. DOI: 10.1089/jmf.2010.0178. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3, EtOAc, MeOH
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in root

Composition #7: Castaneda Sortibran, America., Ordaz Tellez, Maria Guadalupe., Ocotero, Veronica Munoz., Antonio Carballo-Ontiveros, Marco., Garcia, Angelica Mendez., Jimenez Valdes, Rocio Jimena., Romero Gutierrez, Elizabeth., Rodriguez-Arnaiz, Rosario. Chronic Toxicity, Genotoxic Assay, and Phytochemical Analysis of Four Traditional Medicinal Plants. JOURNAL OF MEDICINAL FOOD, 2011, vol. 14, no. 9, p. 1018–1022. DOI: 10.1089/jmf.2010.0178. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3, EtOAc, MeOH
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins in root

Composition #8: Rivero, Isabel., Juarez, Krutzkaya., Zuluaga, Magda., Bye, Robert., Mata, Rachel. Quantitative HPLC Method for Determining Two of the Major Active Phthalides from Ligusticum porteri Roots. JOURNAL OF AOAC INTERNATIONAL, 2012, vol. 95, no. 1, p. 84–91. DOI: 10.5740/jaoacint.11-151. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hexane, Dichloromethane, Hexane–dichloromethane (1:1), Methanol, Dichloromethane–methanol (1:1)
Substance:

Z-ligustilide (RF-00011188-PAR)
Additional substance description:
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.4-22.6
Internal remarks:

Z-ligustilide in root

Composition #9: Rivero, Isabel., Juarez, Krutzkaya., Zuluaga, Magda., Bye, Robert., Mata, Rachel. Quantitative HPLC Method for Determining Two of the Major Active Phthalides from Ligusticum porteri Roots. JOURNAL OF AOAC INTERNATIONAL, 2012, vol. 95, no. 1, p. 84–91. DOI: 10.5740/jaoacint.11-151. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

3-Butylidenephthalide 3-Butylidenephthalide (RF-00001798-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

24.41
Internal remarks:

(Z)-3-butylidenephthalide in root

Composition #10: Rivero, Isabel., Juarez, Krutzkaya., Zuluaga, Magda., Bye, Robert., Mata, Rachel. Quantitative HPLC Method for Determining Two of the Major Active Phthalides from Ligusticum porteri Roots. JOURNAL OF AOAC INTERNATIONAL, 2012, vol. 95, no. 1, p. 84–91. DOI: 10.5740/jaoacint.11-151. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Z-ligustilide (RF-00011188-PAR)
Additional substance description:
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

20.20
Internal remarks:

Z-ligustilide in root

Composition #11: Leon, Alejandra., Antonio Cogordan, J., Sterner, Olov., Delgado, Guillermo. Enantiomeric Derivatives of Tokinolide B: Absolute Configuration and Biological Properties. JOURNAL OF NATURAL PRODUCTS, 2012, vol. 75, no. 5, p. 859–864. DOI: 10.1021/np200645p. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Acetone
Substance:

Tokinolide B (RF-00011221-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tokinolide B

Endpoint study #1: Brindis, Fernando., Rodriguez, Rogelio., Bye, Robert., Gonzalez-Andrade, Martin., Mata, Rachel. (Z)-3-Butylidenephthalide from Ligusticum porteri, an alpha-Glucosidase Inhibitor. JOURNAL OF NATURAL PRODUCTS, 2011, vol. 74, no. 3, p. 314–320. DOI: 10.1021/np100447a. [DOI link]

Study relevance:

Human health
Substance:

3-Butylidenephthalide 3-Butylidenephthalide (RF-00001798-PAR)
Type of toxicological test:

other (CHD008TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

No data
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

180.0
Unit of exposure duration:

Minute (G074A)
Number of organisms dosed:

6
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

10
Critical effect:

Digestive (TOX18A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

antihyperglycemic activity (alpha-glucosidase inhibition)
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-glucosidase inhibition by 3-butylidenephthalide