EFSA Compendium of Botanicals

Draft - work in progress

Ligusticum mutellina (L.) Crantz // Meum mutellina (L.) Gaertn.

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 28
Number of processed references:: 5

Compositions

Endpoint Studies

Genotoxicity

Composition #1: Brandt, Juergen J., Schultze, Wulf. Composition of the essential oils of Ligusticum mutellina (L.) Crantz (Apiaceae). Journal of Essential Oil Research, 1995, p. 231–235. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dihydrodistillation
Substance:

myristicin (RF-00003941-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

26.8
Internal remarks:

Myristicin (phenylpropenoid) in essential oil from roots

Composition #2: Brandt, Juergen J., Schultze, Wulf. Composition of the essential oils of Ligusticum mutellina (L.) Crantz (Apiaceae). Journal of Essential Oil Research, 1995, p. 231–235. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myristicin (RF-00003941-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

35.12
Internal remarks:

myristicin (phenylpropenoid) in essential oil from fruit

Composition #3: Brandt, Juergen J., Schultze, Wulf. Composition of the essential oils of Ligusticum mutellina (L.) Crantz (Apiaceae). Journal of Essential Oil Research, 1995, p. 231–235. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myristicin (RF-00003941-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

39.3
Internal remarks:

Myristicin (phenylpropenoid) in essential oil from herb

Composition #4: Brandt, Juergen J., Schultze, Wulf. Composition of the essential oils of Ligusticum mutellina (L.) Crantz (Apiaceae). Journal of Essential Oil Research, 1995, p. 231–235. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistllationn
Substance:

Dillapiole (RF-00004277-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

10.02
Internal remarks:

Dillapiole ( phenylpropenoid) in essential oil from herb

Composition #5: Brandt, Juergen J., Schultze, Wulf. Composition of the essential oils of Ligusticum mutellina (L.) Crantz (Apiaceae). Journal of Essential Oil Research, 1995, p. 231–235. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillatin
Substance:

apiole (RF-00003690-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

17.4
Internal remarks:

Apiol (phenylpropenoid) in essential oil from fruit

Composition #6: Brandt, Juergen J., Schultze, Wulf. Composition of the essential oils of Ligusticum mutellina (L.) Crantz (Apiaceae). Journal of Essential Oil Research, 1995, p. 231–235. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Dillapiole (RF-00004277-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.01
Internal remarks:

Dillapiole (phenylpropenoid) in essential oil from root

Composition #7: Brandt, Juergen J., Schultze, Wulf. Composition of the essential oils of Ligusticum mutellina (L.) Crantz (Apiaceae). Journal of Essential Oil Research, 1995, p. 231–235. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

ligustilide (RF-00003900-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

19.1
Internal remarks:

Ligustilide (phenylpropenoid) in essential oil from root

Composition #8: Spitaler, R., Ellmerer-Müller, E.-P., Zidorn, C., Stuppner, H. Phenylpropanoids and polyacetylenes from Ligusticum mutellina (apiaceae) of tyrolean origin. Scientia Pharmaceutica, 2002, vol. 70, no. 1, p. 101–109. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichlormethan with further modification
Substance:

phenylpropanoids (RF-00004367-PAR)
Additional substance description:

isoelemicin, trans-isomyristicin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isoelemicin, trans-isomyristicin
completed:

True

Composition #9: Spitaler, R., Ellmerer-Müller, E.-P., Zidorn, C., Stuppner, H. Phenylpropanoids and polyacetylenes from Ligusticum mutellina (apiaceae) of tyrolean origin. Scientia Pharmaceutica, 2002, vol. 70, no. 1, p. 101–109. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichlormethan with further modification
Substance:

polyacetylene derivatives polyacetylene derivatives (RF-00004332-PAR)
Additional substance description:

falcarindiol and derivatives
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

falcarindiol and derivatives
completed:

True

Composition #10: Kramer, Maike., Muehleis, Andrea., Conrad, Juergen., Leitenberger, Martin., Beifuss, Uwe., Carle, Reinhold., Kammerer, Dietmar R. Quantification of Polyacetylenes in Apiaceous Plants by High-Performance Liquid Chromatography Coupled with Diode Array Detection. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2011, vol. 66, no. 7-8, p. 319–327. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol with further modification
Substance:

falcarindiol (RF-00003811-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/kilogram (G061A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

161.33
Internal remarks:

falcarindiol (polyacetylene)
completed:

True

Composition #11: Sieniawska, Elwira., Baj, Tomasz., Los, Renata., Skalicka-Wozniak, Krystyna., Malm, Anna., Glowniak, Kazimierz. Phenolic acids content, antioxidant and antimicrobial activity of Ligusticum mutellina L.. NATURAL PRODUCT RESEARCH, 2013, vol. 27, no. 12, p. 1108–1110. DOI: 10.1080/14786419.2012.698413. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

gallic acid

Composition #12: Sieniawska, Elwira., Baj, Tomasz., Ulewicz-Magulska, Beata., Wesolowski, Marek., Glowniak, Kazimierz. The essential oils from Ligusticum mutellina of polish origin and the chemical relationship of its root essential oil with other Ligusticum species . biochemical systematics and ecology, 2013, vol. 49, p. 125–130. DOI: 10.1016/j.bse.2013.03.024. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.9
Internal remarks:

Myrcene in essential oil from flowers

Composition #13: Sieniawska, Elwira., Baj, Tomasz., Ulewicz-Magulska, Beata., Wesolowski, Marek., Glowniak, Kazimierz. The essential oils from Ligusticum mutellina of polish origin and the chemical relationship of its root essential oil with other Ligusticum species . biochemical systematics and ecology, 2013, vol. 49, p. 125–130. DOI: 10.1016/j.bse.2013.03.024. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydroddistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.1
Internal remarks:

Myrcene in essential oil from herb

Composition #14: Sieniawska, Elwira., Baj, Tomasz., Ulewicz-Magulska, Beata., Wesolowski, Marek., Glowniak, Kazimierz. The essential oils from Ligusticum mutellina of polish origin and the chemical relationship of its root essential oil with other Ligusticum species . biochemical systematics and ecology, 2013, vol. 49, p. 125–130. DOI: 10.1016/j.bse.2013.03.024. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.9
Internal remarks:

Myrcene in essential oil from root