EFSA Compendium of Botanicals

Draft - work in progress

Ligularia dentata (A.Gray) Hara

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 39
Number of processed references:: 2

Compositions

#1: Ligularidine (pyrrolizidine alkaloid) #2: Clivorine (pyrrolizidine alkaloid)

Endpoint Studies

Genotoxicity

Composition #1: Asada, Yoshihisa., Furuya, Tsutomu. Studies on constituents of crude drugs. XV. New pyrrolizidine alkaloids from Ligularia dentata. chemical pharmaceutical bulletin, 1984, p. 475–482. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Ligularidine (RF-00008631-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Ligularidine (pyrrolizidine alkaloid)

Composition #2: Asada, Yoshihisa., Furuya, Tsutomu. Studies on constituents of crude drugs. XV. New pyrrolizidine alkaloids from Ligularia dentata. chemical pharmaceutical bulletin, 1984, p. 475–482. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Clivorine (RF-00000272-TOX)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Clivorine (pyrrolizidine alkaloid)

Endpoint study #1: KUHARA, K., TAKANASHI, H., HIRONO, I., FURUYA, T., ASADA, Y. CARCINOGENIC ACTIVITY OF CLIVORINE, A PYRROLIZIDINE ALKALOID ISOLATED FROM LIGULARIA-DENTATA. CANCER LETTERS, 1980, vol. 10, no. 2, p. 117–122. DOI: 10.1016/0304-3835(80)90034-8. [DOI link]

Study relevance:

Human health
Substance:

Clivorine (RF-00000272-TOX)
Type of toxicological test:

chronic/long term toxicity (CHD004TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Male/Female
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

340.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

12
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Percent (G138A)
Effect concentration:

0.005
Critical effect:

SYSTEMIC (TOX01A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

tumors in the liver; hemangioendothelial sarcomas, neoplastic nodules, metastasis in the lung
Effect or parameter linked to the endpoint:

Carcinogenic (CHD036BE)
Internal remarks:

Clivorine is carcinogenic