EFSA Compendium of Botanicals

Draft - work in progress

Lepidium latifolium L.

Family:: Brassicaceae
Approval state:: Approved
Number of articles retrieved:: 206
Number of processed references:: 3

Compositions

#1: Two alkaloids #2: One saponin #3: Weak reaction for cyanogenesis

Endpoint Studies

#1: Administration of an aqueous extract of leaves with boiling water (50-100 mg/kg) resulted in an increased urinary excretion

Genotoxicity

Composition #1: Simoes, E. Pedride., da Fonseca, J. L. Lobato. Pharmacodynamics of Lepidium latifolium. congr. luso-espan. farm., 1952, p. 218–228. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Two alkaloids

Composition #2: Simoes, E. Pedride., da Fonseca, J. L. Lobato. Pharmacodynamics of Lepidium latifolium. congr. luso-espan. farm., 1952, p. 218–228. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

One saponin

Composition #3: Hegnauer, R. Distribution of cyanogenesis in cormophytes. pharmaceutisch weekblad, 1958, p. 801–819. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Additional extraction description:

unspecified
Substance:

Cyanide (RF-00000021-CHE)
Additional substance description:

weak reaction for cyanogenesis with plants at pre-flowering stage
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Weak reaction for cyanogenesis

Endpoint study #1: NAVARRO, E., ALONSO, J., RODRIGUEZ, R., TRUJILLO, J., BOADA, J. DIURETIC ACTION OF AN AQUEOUS EXTRACT OF LEPIDIUM-LATIFOLIUM L. journal of ethnopharmacology, 1994, vol. 41, no. 1-2, p. 65–69. DOI: 10.1016/0378-8741(94)90059-0. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

boiling water
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Female
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Number of organisms dosed:

10
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

50
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

Increased urine excretion
Effect or parameter linked to the endpoint:

urinalysis (CHD029BE)
Internal remarks:

Administration of an aqueous extract of leaves with boiling water (50-100 mg/kg) resulted in an increased urinary excretion