EFSA Compendium of Botanicals

Draft - work in progress

Leonotis nepetifolia (L.) R.Br.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 73
Number of processed references:: 5

Endpoint Studies

#1: leaves induce labour in pregnant women

Genotoxicity

Composition #1: Thoppil, John Ernest., Jose, Joseph. Chromosome architecture and major essential oil constituents in Leonotis nepetifolia (L.) Ait.f. from South India . acta pharmaceutica (zagreb), 1995, vol. 45, no. 1, p. 25–28. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methylisoeugenol (RF-00003493-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.8
Internal remarks:

methylisoeugenol

Composition #2: Thoppil, John Ernest., Jose, Joseph. Chromosome architecture and major essential oil constituents in Leonotis nepetifolia (L.) Ait.f. from South India . acta pharmaceutica (zagreb), 1995, vol. 45, no. 1, p. 25–28. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.9
Internal remarks:

eugenol

Composition #3: Thoppil, John Ernest., Jose, Joseph. Chromosome architecture and major essential oil constituents in Leonotis nepetifolia (L.) Ait.f. from South India . acta pharmaceutica (zagreb), 1995, vol. 45, no. 1, p. 25–28. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

p-Menth-1-en-3-one (RF-00009951-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.4
Internal remarks:

piperitone

Composition #4: Thoppil, John Ernest., Jose, Joseph. Chromosome architecture and major essential oil constituents in Leonotis nepetifolia (L.) Ait.f. from South India . acta pharmaceutica (zagreb), 1995, vol. 45, no. 1, p. 25–28. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

p-Mentha-1,4(8)-dien-3-one (RF-00009950-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.6
Internal remarks:

piperitenone

Composition #5: Thoppil, John Ernest., Jose, Joseph. Chromosome architecture and major essential oil constituents in Leonotis nepetifolia (L.) Ait.f. from South India . acta pharmaceutica (zagreb), 1995, vol. 45, no. 1, p. 25–28. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Piperitenone oxide (RF-00008725-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.4
Internal remarks:

piperitenone oxide

Composition #6: Sobolewska, Danuta., Pasko, Pawel., Galanty, Agnieszka., Makowska-Was, Justyna., Padlo, Kinga., Wasilak, Wojciech. Preliminary phytochemical and biological screening of methanolic and acetone extracts from Leonotis nepetifolia (L.) R. Br. journal of medicinal plants research, 2012, p. 4582–4585. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Additional extraction description:

solvent extraction, hot water extraction
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins

Composition #7: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

15-epi-leonepetaefolin A
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

15-epi-leonepetaefolin A

Composition #8: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

Leonepetaefolin A
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Leonepetaefolin A

Composition #9: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

Leonepetaefolin B
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Leonepetaefolin B

Composition #10: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

Leonepetaefolin C
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Leonepetaefolin C

Composition #11: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

Leonepetaefolin D
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Leonepetaefolin D

Composition #12: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

15-epi-leonepetaefolin E
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

15-epi-leonepetaefolin E

Composition #13: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

15-epi-leonepetaefolin B
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

15-epi-leonepetaefolin B

Composition #14: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

15-epi-leonepetaefolin C
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

15-epi-leonepetaefolin C

Composition #15: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

15-epi-leonepetaefolin D
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

15-epi-leonepetaefolin D

Composition #16: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

methoxynepataefolin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

methoxynepataefolin

Composition #17: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

nepetaefolin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

nepetaefolin

Composition #18: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

nepetaefuran
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

nepetaefuran

Composition #19: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

dubiin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

dubiin

Composition #20: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

leonotinin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

leonotinin

Composition #21: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

leonotin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

leonotin

Composition #22: Li, J., Fronczek, F.R., Ferreira, D., Burandt, C.L., Setola, V., Roth, B.L., Zjawiony, J.K. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. Journal of Natural Products, 2012, vol. 75, no. 4, p. 728–734. DOI: 10.1021/np3000156. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:Methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

LS-1
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

LS-1

Composition #23: Pushpan, R., Nishteswar, K., Kumari, H. Ethno medicinal claims of Leonotis nepetifolia (L.) R. Br: A review. international journal of research in ayurveda and pharmacy, 2012, vol. 3, no. 6, p. 784–785. DOI: 10.7897/2277-4343.03617. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Additional extraction description:

unspecified
Substance:

labdane diterpenes (RF-00004392-PAR)
Additional substance description:

Leonotinin, nepetaefolinol
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

labdane diterpenes

Composition #24: Pushpan, R., Nishteswar, K., Kumari, H. Ethno medicinal claims of Leonotis nepetifolia (L.) R. Br: A review. international journal of research in ayurveda and pharmacy, 2012, vol. 3, no. 6, p. 784–785. DOI: 10.7897/2277-4343.03617. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Additional extraction description:

unspecified
Substance:

Coumarin (RF-00000370-TOX)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumarin

Endpoint study #1: Kamatenesi-Mugisha, M., Oryem-Origa, H. Medicinal plants used to induce labour during childbirth in western Uganda. journal of ethnopharmacology, 2007, vol. 109, no. 1, p. 1–9. DOI: 10.1016/j.jep.2006.06.011. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Raw, no heat treatment (A07HS)
Type of toxicological test:

other (CHD008TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

Labour induction
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

leaves induce labour in pregnant women