EFSA Compendium of Botanicals

Draft - work in progress

Laser trilobum (L.) Borkh.

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 67
Number of processed references:: 2

Compositions

#1: Sesquiterpene coumarins #2: Sesquiterpene lactones - eudesmanolide type #3: Sesquiterpene lactones - germacranolide type #4: Sesquiterpene lactones - guaianolide type

Endpoint Studies

Genotoxicity

Composition #1: Azizov, Yu. M., Serkerov, S. V. To chemical study of Laser trilobum (L.) Borkh of Azerbaijan flora. Khimiya Rastitel'nogo Syr'ya, 2011, p. 169–172. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

unspecified
Substance:

Sesquiterpene coumarins (RF-00010810-PAR)
Additional substance description:

crocatone (latifolone), laserine and derivatives
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene coumarins

Composition #2: Harmatha, Juraj., Budesinsky, Milos., Vokac, Karel., Kostecka, Petra., Kmonickova, Eva., Zidek, Zdenek. Trilobolide and related sesquiterpene lactones from Laser trilobum possessing immunobiological properties. FITOTERAPIA, 2013, vol. 89, p. 157–166. DOI: 10.1016/j.fitote.2013.05.025. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ethyl-ether acetate
Substance:

sesquiterpene lactones type eudesmanolide sesquiterpene lactones type eudesmanolide (RF-00004395-PAR)
Additional substance description:

Eudeslaserolide
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene lactones - eudesmanolide type

Composition #3: Harmatha, Juraj., Budesinsky, Milos., Vokac, Karel., Kostecka, Petra., Kmonickova, Eva., Zidek, Zdenek. Trilobolide and related sesquiterpene lactones from Laser trilobum possessing immunobiological properties. FITOTERAPIA, 2013, vol. 89, p. 157–166. DOI: 10.1016/j.fitote.2013.05.025. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ethyl-ether acetate
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

germacranolide type
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene lactones - germacranolide type

Composition #4: Harmatha, Juraj., Budesinsky, Milos., Vokac, Karel., Kostecka, Petra., Kmonickova, Eva., Zidek, Zdenek. Trilobolide and related sesquiterpene lactones from Laser trilobum possessing immunobiological properties. FITOTERAPIA, 2013, vol. 89, p. 157–166. DOI: 10.1016/j.fitote.2013.05.025. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ethyl-ether acetate
Substance:

guaianolides (RF-00010821-PAR)
Additional substance description:

2-acetoxytrilobolide and 2-hydroxy-10-deacetyltrilobolide
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene lactones - guaianolide type