Composition #1: Cai, T., Qi, W., Yang, L., Tu, G., Yang, R., Xie, K., Fu, H. Chemical constituents of Pseudolarix kaempferi Gord. Journal of Chinese Pharmaceutical Sciences, 2012, vol. 21, no. 5, p. 428–435. DOI: 10.5246/jcps.2012.05.057.
[DOI link]
Language:
English (en)
Plant part:
Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:
Solvent extraction (A0BZR)
Additional extraction description:
Methanol
Substance:
Isopimpinellin (RF-00003784-PAR)
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:
column chromatography
Yes/No Qualitative:
Positive/Present (POS)
Result type:
Qualitative Value (Binary) (BIN)
Internal remarks:
isopimpinellin
Composition #2: Cai, T., Qi, W., Yang, L., Tu, G., Yang, R., Xie, K., Fu, H. Chemical constituents of Pseudolarix kaempferi Gord. Journal of Chinese Pharmaceutical Sciences, 2012, vol. 21, no. 5, p. 428–435. DOI: 10.5246/jcps.2012.05.057.
[DOI link]
Language:
English (en)
Plant part:
Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:
Solvent extraction (A0BZR)
Additional extraction description:
Methanol
Substance:
calycosin (RF-00004191-PAR)
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:
column chromatography
Yes/No Qualitative:
Positive/Present (POS)
Result type:
Qualitative Value (Binary) (BIN)
Internal remarks:
calycosin
Composition #3: Cai, T., Qi, W., Yang, L., Tu, G., Yang, R., Xie, K., Fu, H. Chemical constituents of Pseudolarix kaempferi Gord. Journal of Chinese Pharmaceutical Sciences, 2012, vol. 21, no. 5, p. 428–435. DOI: 10.5246/jcps.2012.05.057.
[DOI link]
Language:
English (en)
Plant part:
Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:
Solvent extraction (A0BZR)
Additional extraction description:
Methanol
Substance:
3,4-Dihydroxybenzoic acid (RF-00008853-PAR)
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:
column chromatography
Yes/No Qualitative:
Positive/Present (POS)
Result type:
Qualitative Value (Binary) (BIN)
Internal remarks:
Protocatechuic acid
Composition #4: Cai, T., Qi, W., Yang, L., Tu, G., Yang, R., Xie, K., Fu, H. Chemical constituents of Pseudolarix kaempferi Gord. Journal of Chinese Pharmaceutical Sciences, 2012, vol. 21, no. 5, p. 428–435. DOI: 10.5246/jcps.2012.05.057.
[DOI link]
Language:
English (en)
Plant part:
Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:
Solvent extraction (A0BZR)
Additional extraction description:
Methanol
Substance:
umbelliferone (RF-00004096-PAR)
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:
column chromatography
Yes/No Qualitative:
Positive/Present (POS)
Result type:
Qualitative Value (Binary) (BIN)
Internal remarks:
umbelliferone
Composition #5: Cai, T., Qi, W., Yang, L., Tu, G., Yang, R., Xie, K., Fu, H. Chemical constituents of Pseudolarix kaempferi Gord. Journal of Chinese Pharmaceutical Sciences, 2012, vol. 21, no. 5, p. 428–435. DOI: 10.5246/jcps.2012.05.057.
[DOI link]
Language:
English (en)
Plant part:
Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:
Solvent extraction (A0BZR)
Additional extraction description:
Methanol
Substance:
formononetin (RF-00000291-NTR)
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:
column chromatography
Yes/No Qualitative:
Positive/Present (POS)
Result type:
Qualitative Value (Binary) (BIN)
Internal remarks:
Formononetin
Endpoint study
#1: Wang, Weicheng., Lu, Rongfa., Zhao, Shixing., Gu, Zhiping. Comparison of early pregnancy-terminating effect and toxicity between pseudolaric acids A and B. zhongguo yaoli xuebao, 1988, p. 445–448. .
Study relevance:
Human health
Plant part:
Bark (as part-nature) (A066X)
Additional plant/substance description:
pseudolaric acids A and B
Type of toxicological test:
reproduction toxicity (CHD009TT)
Tested organism:
Rat (as animal) (A0CNV)
Sex:
Female
Route of exposure:
ORAL: GAVAGE (OECD2231PL)
Exposure duration:
7.0
Unit of exposure duration:
Day (G134A)
Endpoint measured:
Concentration level (CHD013EP)
Concentration unit:
Milligram/kilogram (G061A)
Effect concentration:
8.2
Critical effect:
REPRODUCTIVE (TOX05A)
Target tissue:
urogenital: Uterus (TT052A)
Effect description:
early pregnancy-terminating effect
Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
Internal remarks:
Reproduction toxicity in rats
Endpoint study
#2: Wang, Weicheng., Lu, Rongfa., Zhao, Shixing., Gu, Zhiping. Comparison of early pregnancy-terminating effect and toxicity between pseudolaric acids A and B. zhongguo yaoli xuebao, 1988, p. 445–448. .
