EFSA Compendium of Botanicals

Draft - work in progress

Lantana camara L.

Family:: Verbenaceae
Approval state:: Approved
Number of articles retrieved:: 2431
Number of processed references:: 7

Compositions

#1: Phytin #2: Nitrite #3: Oxalates #4: Cyanide

Endpoint Studies

#1: Abnormal high haematocrit values and plasma bilirubin 5 to 50 times higher than normal. Five animals died. #2: The histopathological alterations observed in the liver of lantadene administered groups strongly indicated severe hepatic damage due to lantadene intoxication. Death occurred at higher dose levels. Reduced body weight gain in all guinea pigs. #3: significant reduction of both cellular and humoral immunity due to L. camara toxicity #4: Vomiting, abominal pain, diarrhea, throuth mouth irritation. Many asymptomatic cases. #5: Icterus, mild photosensitivity, ascites, and microscopical changes in the liver compatible with Lantana camara poisoning. #6: Hepatotoxicity #7: Nephrotoxicity

Genotoxicity

Composition #1: Abatan, M. O., Arowolo, R. O., Olurunsogo, O. O. Phytochemical analysis of some commonly occurring poisonous plants in Nigerian pastures . tropical veterinarian, 1997, vol. 15, no. 1-2, p. 49–54. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

HCl
Substance:

phytic acid (RF-00000363-NTR)
Additional substance description:

Phytin
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

15.99
Internal remarks:

Phytin

Composition #2: Abatan, M. O., Arowolo, R. O., Olurunsogo, O. O. Phytochemical analysis of some commonly occurring poisonous plants in Nigerian pastures . tropical veterinarian, 1997, vol. 15, no. 1-2, p. 49–54. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

HCl
Substance:

Nitrites Nitrites (RF-00000087-CHE)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9.5
Internal remarks:

Nitrite

Composition #3: Abatan, M. O., Arowolo, R. O., Olurunsogo, O. O. Phytochemical analysis of some commonly occurring poisonous plants in Nigerian pastures . tropical veterinarian, 1997, vol. 15, no. 1-2, p. 49–54. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

HCl
Substance:

Oxalates (RF-00004308-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.148
Internal remarks:

Oxalates

Composition #4: Abatan, M. O., Arowolo, R. O., Olurunsogo, O. O. Phytochemical analysis of some commonly occurring poisonous plants in Nigerian pastures . tropical veterinarian, 1997, vol. 15, no. 1-2, p. 49–54. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

HCl
Substance:

Cyanide (RF-00000021-CHE)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

12.7
Internal remarks:

Cyanide

Endpoint study #1: Sharma, O.P., Makkar, H.P.S., Pal, R.N., Negi, S.S. Fragility of erythrocytes in animals affected by lantana poisoning. Clinical Toxicology, 1981, vol. 18, no. 1, p. 25–35. DOI: 10.3109/15563658108990010. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Unspecified (A07XD)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Cattle (as animal) (A057E)
Sex:

Male/Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Number of organisms dosed:

7
Control groups used:

yes
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

HEMOPOIETIC (TOX10A)
Target tissue:

cardiovascular / haematological: Blood Coagulation (TT010A)
Effect description:

Abnormal high haematocrit values and plasma bilirubin 5 to 50 times higher than normal. Five animals died.
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

Abnormal high haematocrit values and plasma bilirubin 5 to 50 times higher than normal. Five animals died.

Endpoint study #2: Parimoo, H.A., Sharma, R., Patil, R.D., Patial, V. Sub-acute toxicity of lantadenes isolated from Lantana camara leaves in guinea pig animal model. Comparative Clinical Pathology, 2015 . DOI: 10.1007/s00580-015-2114-z. [DOI link]

Study relevance:

Human health
Substance:

Lantadene A (RF-00010957-PAR)
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

lantadenes (72.82 percent lantadene A)
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Guinea pig (as animal) (A0CTN)
Sex:

Male/Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

28.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

20
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

12.5
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

histopathological alterations indicating severe hepatic damage due to lantadene intoxication. Death occurred at higher dose levels.
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

The histopathological alterations observed in the liver of lantadene administered groups strongly indicated severe hepatic damage due to lantadene intoxication. Death occurred at higher dose levels. Reduced body weight gain in all guinea pigs.

Endpoint study #3: Ganai, G N., Jha, G J. Immunosuppression due to chronic Lantana camara, L. toxicity in sheep.. indian journal of experimental biology, 1991, vol. 29, no. 8, p. 762–6. .

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Powder (A06JD)
Type of toxicological test:

subchronic (CHD013TT)
Tested organism:

Sheep (as animal) (A057G)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

110.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

5
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

200
Critical effect:

IMMUNOTOXICITY (TOX09A)
Target tissue:

cardiovascular / haematological: Lymph Nodes (TT013A)
Effect description:

significant reduction of both cellular and humoral immunity due to L. camara toxicity
Effect or parameter linked to the endpoint:

immunology (CHD026BE)
Internal remarks:

significant reduction of both cellular and humoral immunity due to L. camara toxicity

Endpoint study #4: Carstairs Shaun D., Luk Joyce Y., Tomaszewski Christian A., Cantrell F Lee. Ingestion of Lantana camara is not associated with significant effects in children. pediatrics, 2010, p. e1585–e1588. .

Study relevance:

Human health
Plant part:

Fruit unspecified (as part-nature) (A067D)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

No data
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

Vomiting, abominal pain, diarrhea, throuth mouth irritation. Many asymptomatic cases.
Effect or parameter linked to the endpoint:

other (CHD003BE)
Internal remarks:

Vomiting, abominal pain, diarrhea, throuth mouth irritation. Many asymptomatic cases.

Endpoint study #5: Fourie, N., Van der Lugt, J J., Newsholme, S J., Nel, P W. Acute Lantana camara toxicity in cattle.. Journal of the South African Veterinary Association, 1987, vol. 58, no. 4, p. 173–8. .

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Cattle (as animal) (A057E)
Sex:

No data
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

5.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

2
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Gram/kilogram (G015A)
Effect concentration:

5-15
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

Icterus, mild photosensitivity, ascites, and microscopical changes in the liver compatible with Lantana camara poisoning.
Effect or parameter linked to the endpoint:

histopathology neoplastic (CHD024BE)
Internal remarks:

Icterus, mild photosensitivity, ascites, and microscopical changes in the liver compatible with Lantana camara poisoning.

Endpoint study #6: Ide, A., Tutt, CLC. Acute Lantana camara poisoning in a Boer goat kid. journal of the south african veterinary association-tydskrif van die suid-afrikaanse veterinere vereniging, 1998, vol. 69, no. 1, p. 30–32. .

Study relevance:

Animal (target species) health
Plant part:

Unspecified (A07XD)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Goat (as animal) (A057P)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Number of organisms dosed:

1
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

Icterus, hepatatotoxicity (single cell necrosis), distension of the gall bladder and bile stasis.
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

Hepatotoxicity

Endpoint study #7: Ide, A., Tutt, CLC. Acute Lantana camara poisoning in a Boer goat kid. journal of the south african veterinary association-tydskrif van die suid-afrikaanse veterinere vereniging, 1998, vol. 69, no. 1, p. 30–32. .

Study relevance:

Animal (target species) health
Plant part:

Unspecified (A07XD)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Goat (as animal) (A057P)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Number of organisms dosed:

1
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

Kidney lesions with areas of coagulative necrosis of the proximal tubules, predominantly in the cortex.
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

Nephrotoxicity