EFSA Compendium of Botanicals

Draft - work in progress

Lagerstroemia speciosa (L.) Pers.

Family:: Lythraceae
Approval state:: Approved
Number of articles retrieved:: 437
Number of processed references:: 5

Compositions

#1: Tannins #2: Alkaloid #3: Saponins #4: 3-O-methylprotocatechuic acid #5: Ellagitannins #6: 4-hydroxybenzoic acid #7: Calcium oxalate #8: Gallic acid

Endpoint Studies

#1: alpha-glucosidase inhibition

Genotoxicity

Composition #1: Hussain, F., Ganguly, A., Hossain, M.S., Abdur Rahman, S.M. Analgesic and anti-diarrhoeal activities of lagerstroemia speciosa roots in experimental animal model. Dhaka University Journal of Pharmaceutical Sciences, 2014, vol. 13, no. 1, p. 57–62. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #2: Hussain, F., Ganguly, A., Hossain, M.S., Abdur Rahman, S.M. Analgesic and anti-diarrhoeal activities of lagerstroemia speciosa roots in experimental animal model. Dhaka University Journal of Pharmaceutical Sciences, 2014, vol. 13, no. 1, p. 57–62. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloid

Composition #3: Hussain, F., Ganguly, A., Hossain, M.S., Abdur Rahman, S.M. Analgesic and anti-diarrhoeal activities of lagerstroemia speciosa roots in experimental animal model. Dhaka University Journal of Pharmaceutical Sciences, 2014, vol. 13, no. 1, p. 57–62. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #4: Bai, Naisheng., He, Kan., Roller, Marc., Zheng, Bolin., Chen, Xiaozhuo., Shao, Zhongguang., Peng, Tangsheng., Zheng, Qunyi. Active Compounds from Lagerstroemia speciosa, Insulin-like Glucose Uptake-Stimulatory/Inhibitory and Adipocyte Differentiation-Inhibitory Activities in 3T3-L1 Cells. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, vol. 56, no. 24, p. 11668–11674. DOI: 10.1021/jf802152z. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone/water
Substance:

3,4-Dihydroxybenzoic acid (RF-00008853-PAR)
Additional substance description:

3-O-methylprotocatechuic acid
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

and ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

3-O-methylprotocatechuic acid

Composition #5: Bai, Naisheng., He, Kan., Roller, Marc., Zheng, Bolin., Chen, Xiaozhuo., Shao, Zhongguang., Peng, Tangsheng., Zheng, Qunyi. Active Compounds from Lagerstroemia speciosa, Insulin-like Glucose Uptake-Stimulatory/Inhibitory and Adipocyte Differentiation-Inhibitory Activities in 3T3-L1 Cells. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, vol. 56, no. 24, p. 11668–11674. DOI: 10.1021/jf802152z. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone/water
Substance:

Ellagitannins (hydrolysable tannins) Ellagitannins (hydrolysable tannins) (RF-00004379-PAR)
Additional substance description:

lagerstroemin, flosin B, stachyurin, casuarinin, casuariin, epipunicacortein A
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

and ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Ellagitannins

Composition #6: Bai, Naisheng., He, Kan., Roller, Marc., Zheng, Bolin., Chen, Xiaozhuo., Shao, Zhongguang., Peng, Tangsheng., Zheng, Qunyi. Active Compounds from Lagerstroemia speciosa, Insulin-like Glucose Uptake-Stimulatory/Inhibitory and Adipocyte Differentiation-Inhibitory Activities in 3T3-L1 Cells. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, vol. 56, no. 24, p. 11668–11674. DOI: 10.1021/jf802152z. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone/water
Substance:

4-Hydroxybenzoic acid (RF-00008325-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

and ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

4-hydroxybenzoic acid

Composition #7: Thitikornpong, Woratouch., Phadungcharoen, Thatree., Sukrong, Suchada. Pharmacognostic evaluations of Lagerstroemia speciosa leaves. JOURNAL OF MEDICINAL PLANTS RESEARCH, 2011, vol. 5, no. 8, p. 1330–1337. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Substance:

Calcium oxalate (RF-00003960-PAR)
Additional substance description:

Crystals
Analytical method code:

Histology (F162A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Calcium oxalate

Composition #8: Nutan., Modi, Manoj., Goel, Tanvi., Das, Tiyasa., Malik, Shweta., Suri, Samiksha., Rawat, Ajay Kumar Singh., Srivastava, Sharad Kumar., Tuli, Rakesh., Malhotra, Swadesh., Gupta, Satish Kumar. Ellagic acid & gallic acid from Lagerstroemia speciosa L. inhibit HIV-1 infection through inhibition of HIV-1 protease & reverse transcriptase activity. INDIAN JOURNAL OF MEDICAL RESEARCH, 2013, vol. 137, p. 540–548. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

HPLC, NMR and MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Gallic acid

Endpoint study #1: Hou, Wenli., Li, Yanfang., Zhang, Qiang., Wei, Xin., Peng, Aihua., Chen, Lijuan., Wei, Yuquan. Triterpene Acids Isolated from Lagerstroemia speciosa Leaves as alpha-Glucosidase Inhibitors . phytotherapy research, 2009, vol. 23, no. 5, p. 614–618. DOI: 10.1002/ptr.2661. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Ethyl acetate
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

88.72
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-glucosidase inhibition