EFSA Compendium of Botanicals

Draft - work in progress

Kaempferia parviflora Wall. Ex. Baker

Family:: Zingiberaceae
Approval state:: Approved
Number of articles retrieved:: 177
Number of processed references:: 4

Compositions

Endpoint Studies

#1: " The histopathological study showed a tendency towards hepatotoxicity in all dosed males" #2: Hersberger Bioassay on immature orchidectomised male rats. The serum testosterone level was significantly increased in the dosed rats. #3: Reduced body weight in male and female rats dosed with the highest dose 500 mg/kg bw/day #4: significant increase of relative weight of heart, liver, stomach and right kidney in both male and female rats at 500 mg/kg bw/day.

Genotoxicity

Composition #1: Pripdeevech, Patcharee., Pitija, Kitsada., Rujjanawate, Chaiyong., Pojanagaroon, Sermsakul., Kittakoop, Prasat., Wongpornchai, Sugunya. Adaptogenic-active components from Kaempferia parviflora rhizomes. food chemistry, 2012, vol. 132, no. 3, p. 1150–1155. DOI: 10.1016/j.foodchem.2011.11.025. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hexane
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.26
Internal remarks:

1,8-cineole

Endpoint study #1: Sudwan, Paiwan., Saenphet, Kanokporn., Saenphet, Supap., Suwansirikul, Songkiet. Effect of Kaempferia parviflora Wall. ex. Baker on sexual activity of male rats and its toxicity. . the southeast asian journal of tropical medicine and public health, 2006, vol. 37 Suppl 3, p. 210–5. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Ethanolic extract
Type of toxicological test:

subchronic (CHD013TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male
Exposure duration:

60.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

31
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

60
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

"The histopathological study showed a tendency towards hepatotoxicity"
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

" The histopathological study showed a tendency towards hepatotoxicity in all dosed males"

Endpoint study #2: Trisomboon, Hataitip., Watanabe, Gen., Wetchasit, Phongphat., Taya, Kazuyoshi. Effect of daily treatment with Thai herb, Kaempferia parviflora, in Hershberger assay using castrated immature rats . journal of reproduction and development, 2007, vol. 53, no. 2, p. 351–356. DOI: 10.1262/jrd.18092. [DOI link]

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Drying (dehydration) (A07KG)
Additional plant/substance description:

The dried root was suspended in water
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male
Exposure duration:

5.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

15
Control groups used:

yes
Endpoint measured:

No Observed Effect Daily Dose (CHD006EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

1000
Critical effect:

ENDOCRINE (TOX12A)
Target tissue:

Urogenital (TT006A)
Effect description:

The serum testosterone level was significantly increased in the dosed rats.
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Hersberger Bioassay on immature orchidectomised male rats. The serum testosterone level was significantly increased in the dosed rats.

Endpoint study #3: Chivapat, Songpol., Chavalittumrong, Pranee., Attawish, Aimmanas., Rungsipipat, Anudep. Chronic Toxicity Study of Kaempferia parviflora Wall ex. Extract. thai journal of veterinary medicine, 2010, vol. 40, no. 4, p. 377–383. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Ethanolic extract
Type of toxicological test:

chronic/long term toxicity (CHD004TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male/Female
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

6.0
Unit of exposure duration:

Month (G206A)
Number of organisms dosed:

120
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

500
Critical effect:

Other toxicities (TOX19A)
Effect description:

Reduced body weight in male and female rats dosed with the highest dose 500 mg/kg bw/day
Effect or parameter linked to the endpoint:

body weight (CHD005BE)
Internal remarks:

Reduced body weight in male and female rats dosed with the highest dose 500 mg/kg bw/day

Endpoint study #4: Chivapat, Songpol., Chavalittumrong, Pranee., Attawish, Aimmanas., Rungsipipat, Anudep. Chronic Toxicity Study of Kaempferia parviflora Wall ex. Extract. thai journal of veterinary medicine, 2010, vol. 40, no. 4, p. 377–383. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Ethanolic extract
Type of toxicological test:

chronic/long term toxicity (CHD004TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male/Female
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

6.0
Unit of exposure duration:

Month (G206A)
Number of organisms dosed:

120
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

500
Critical effect:

Other toxicities (TOX19A)
Effect description:

significant increase of relative weight of heart, liver, stomach and right kidney in both male and female rats at 500 mg/kg bw/day.
Effect or parameter linked to the endpoint:

organ weights (CHD012BE)
Internal remarks:

significant increase of relative weight of heart, liver, stomach and right kidney in both male and female rats at 500 mg/kg bw/day.