EFSA Compendium of Botanicals

Draft - work in progress

Justicia secunda Vahl

Family:: Acanthaceae
Approval state:: Approved
Number of articles retrieved:: 25
Number of processed references:: 4

Compositions

#1: Anthraquinones #2: Pyrimidine alkaloid: 4,6-diphenyl-2-pyrimidinylamine #3: Aurantiamide acetate (stem) #4: tetrahydrofuranoid lignan (stem) #5: Quindoline #6: tetrahydrofuranoid lignan (roots) #7: Aurantiamide acetate (roots) #8: secundarellone A-C (alkaloids)

Endpoint Studies

Genotoxicity

Composition #1: Akibou Osseni Moukimou, L., Pascal, A.D.C., Annick, B., Yaya, K., Jean Pierre, N.A., Felicien, A., Dominique, S.K.C. Chemical characterization and biological activities of extracts ofthree plants used in traditional medicine in benin: Tectona grandis, uvaria chameae and justicia secunda. asian journal of pharmaceutical and clinical research, 2014, vol. 7, no. 5, p. 23–27. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

anthraquinones (RF-00004343-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Value (concentration, content):

traces
Internal remarks:

Anthraquinones

Composition #2: Gallagher John F., Goswami Shyamaprosad., Chatterjee Baidyanath., Jana Subrata., Dutta Kalyani. N-H.N hydrogen bonding in 4,6-diphenyl-2-pyrimidinylamine isolated from the plant Justicia secunda (Acanthaceae). acta crystallographica. section c, crystal structure communications, 2004, p. o229–o231. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

pyrimidine alkaloid: 4,6-diphenyl-2-pyrimidinylamine
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pyrimidine alkaloid: 4,6-diphenyl-2-pyrimidinylamine

Composition #3: Calderon, Angela I., Hodel, Adam., Wolfender, Jean-Luc., Gupta, Mahabir P., Correa, Mireya., Hostettmann, Kurt. LC-DAD-MS-based metabolite profiling of three species of Justicia (Acanthaceae) . natural product research, 2013, vol. 27, no. 15, p. 1335–1342. DOI: 10.1080/14786419.2012.738207. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichlormethan
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Aurantiamide acetate
Analytical method code:

LC-MS (F026A)
Analytical method - additional description:

LC–DAD–APCI–MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aurantiamide acetate (stem)

Composition #4: Calderon, Angela I., Hodel, Adam., Wolfender, Jean-Luc., Gupta, Mahabir P., Correa, Mireya., Hostettmann, Kurt. LC-DAD-MS-based metabolite profiling of three species of Justicia (Acanthaceae) . natural product research, 2013, vol. 27, no. 15, p. 1335–1342. DOI: 10.1080/14786419.2012.738207. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichlormethan
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

tetrahydrofuranoid lignan
Analytical method code:

LC-MS (F026A)
Analytical method - additional description:

LC–DAD–APCI–MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tetrahydrofuranoid lignan (stem)

Composition #5: Calderon, Angela I., Hodel, Adam., Wolfender, Jean-Luc., Gupta, Mahabir P., Correa, Mireya., Hostettmann, Kurt. LC-DAD-MS-based metabolite profiling of three species of Justicia (Acanthaceae) . natural product research, 2013, vol. 27, no. 15, p. 1335–1342. DOI: 10.1080/14786419.2012.738207. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichlormethan
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

Quindoline
Analytical method code:

LC-MS (F026A)
Analytical method - additional description:

LC–DAD–APCI–MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Quindoline

Composition #6: Calderon, Angela I., Hodel, Adam., Wolfender, Jean-Luc., Gupta, Mahabir P., Correa, Mireya., Hostettmann, Kurt. LC-DAD-MS-based metabolite profiling of three species of Justicia (Acanthaceae) . natural product research, 2013, vol. 27, no. 15, p. 1335–1342. DOI: 10.1080/14786419.2012.738207. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichlormethan
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

tetrahydrofuranoid lignan
Analytical method code:

LC-MS (F026A)
Analytical method - additional description:

LC–DAD–APCI–MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tetrahydrofuranoid lignan (roots)

Composition #7: Calderon, Angela I., Hodel, Adam., Wolfender, Jean-Luc., Gupta, Mahabir P., Correa, Mireya., Hostettmann, Kurt. LC-DAD-MS-based metabolite profiling of three species of Justicia (Acanthaceae) . natural product research, 2013, vol. 27, no. 15, p. 1335–1342. DOI: 10.1080/14786419.2012.738207. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichlormethan
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Aurantiamide acetate
Analytical method code:

LC-MS (F026A)
Analytical method - additional description:

LC–DAD–APCI–MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aurantiamide acetate (roots)

Composition #8: Theiler, Barbara A., Revoltella, Silvia., Zehl, Martin., Dangl, Christina., Caisa, Lugardo O. Espinoza., Koenig, Juergen., Winkler, Johannes., Urban, Ernst., Glasl, Sabine. Secundarellone A, B, and C from the leaves of Justicia secunda VAHL. phytochemistry letters, 2014, vol. 10, p. CXXIX–cxxxii. DOI: 10.1016/j.phytol.2014.05.007. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Pyrrolizidine alkaloids (RF-00000230-TOX)
Additional substance description:

Secundarellone A-C
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

secundarellone A-C (alkaloids)