Draft - work in progress
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- Jatropha multifida L.
Jatropha multifida L.
- Family:
- Euphorbiaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 116
- Number of processed references:
- 10
Composition #1: Adolf, W., Opferkuch, H. J., Hecker, E. Irritant phorbol derivatives from Jatropha species. Phytochemistry (Elsevier), 1984, p. 129–132. .
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
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Substance:
Phorbol esters (RF-00004310-PAR)
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Additional substance description:
polyunsaturated ester of the tlghane-type dlterpenold 16-hydroxyphorbol
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Phorbol ester (seed oil)
Composition #2: Falodun, Abiodun., Igbe, Ighodaro., Erharuyi, Osayemwenre., Agbanyim, Onyinye Jacinta. Chemical characterization, anti inflammatory and analgesic properties of Jatropha multifida root bark. journal of applied sciences and environmental management, 2013, p. 357–362. .
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-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol extraction
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Alkaloids in root bark
Composition #3: Falodun, Abiodun., Igbe, Ighodaro., Erharuyi, Osayemwenre., Agbanyim, Onyinye Jacinta. Chemical characterization, anti inflammatory and analgesic properties of Jatropha multifida root bark. journal of applied sciences and environmental management, 2013, p. 357–362. .
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-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
Tannins (RF-00004337-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Tannins in root bark
Composition #4: Falodun, Abiodun., Igbe, Ighodaro., Erharuyi, Osayemwenre., Agbanyim, Onyinye Jacinta. Chemical characterization, anti inflammatory and analgesic properties of Jatropha multifida root bark. journal of applied sciences and environmental management, 2013, p. 357–362. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
Saponins (RF-00004333-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Saponins in root bark
Composition #5: Settharaksa, S., Pathompak, P., Saingam, W., Madaka, F., Chakree, K., Charoenchai, L. Development and validation of a RP-HPLC method for identification and estimation of gallic acid and protocatechuic acid in trigasornmas recipe. international journal of pharmaceutical, chemical and biological sciences, 2015, p. 388–393. .
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
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Substance:
3,4-Dihydroxybenzoic acid (RF-00008853-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Microgram/millilitre (G052A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
3.4
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Internal remarks:
protocatechuic acid
Composition #6: Nwokocha., Blessing, A., Agbagwa, I.O., Okoli, B.E. Comparative phytochemical screening of Jatropha L. Species in the Niger Delta. research journal of phytochemistry, 2011, vol. 5, no. 2, p. 107–114. DOI: 10.3923/rjphyto.2011.107114.
[
DOI link]
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-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
2.9
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Internal remarks:
Alkaloids (leaf)
Composition #7: Nwokocha., Blessing, A., Agbagwa, I.O., Okoli, B.E. Comparative phytochemical screening of Jatropha L. Species in the Niger Delta. research journal of phytochemistry, 2011, vol. 5, no. 2, p. 107–114. DOI: 10.3923/rjphyto.2011.107114.
[
DOI link]
-
-
Plant part:
Stem / stalk (as part-nature) (A067S)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Substance:
Tannins (RF-00004337-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.2
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Internal remarks:
Tannins (stem)
Composition #8: Nwokocha., Blessing, A., Agbagwa, I.O., Okoli, B.E. Comparative phytochemical screening of Jatropha L. Species in the Niger Delta. research journal of phytochemistry, 2011, vol. 5, no. 2, p. 107–114. DOI: 10.3923/rjphyto.2011.107114.
[
DOI link]
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
2.6
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Internal remarks:
Alkaloids (seed)
Composition #9: Nwokocha., Blessing, A., Agbagwa, I.O., Okoli, B.E. Comparative phytochemical screening of Jatropha L. Species in the Niger Delta. research journal of phytochemistry, 2011, vol. 5, no. 2, p. 107–114. DOI: 10.3923/rjphyto.2011.107114.
[
DOI link]
-
-
Plant part:
Stem / stalk (as part-nature) (A067S)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.7
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Internal remarks:
Alkaloids (stem)
Composition #10: Nwokocha., Blessing, A., Agbagwa, I.O., Okoli, B.E. Comparative phytochemical screening of Jatropha L. Species in the Niger Delta. research journal of phytochemistry, 2011, vol. 5, no. 2, p. 107–114. DOI: 10.3923/rjphyto.2011.107114.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.7
-
Internal remarks:
Alkaloids (root)
Composition #11: Nwokocha., Blessing, A., Agbagwa, I.O., Okoli, B.E. Comparative phytochemical screening of Jatropha L. Species in the Niger Delta. research journal of phytochemistry, 2011, vol. 5, no. 2, p. 107–114. DOI: 10.3923/rjphyto.2011.107114.
[
DOI link]
-
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Substance:
Tannins (RF-00004337-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
5.2
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Internal remarks:
Tannins (leaf)
Composition #12: Nwokocha., Blessing, A., Agbagwa, I.O., Okoli, B.E. Comparative phytochemical screening of Jatropha L. Species in the Niger Delta. research journal of phytochemistry, 2011, vol. 5, no. 2, p. 107–114. DOI: 10.3923/rjphyto.2011.107114.
[
DOI link]
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Substance:
Tannins (RF-00004337-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
3.9
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Internal remarks:
Tannins (seed)
Composition #13: Nwokocha., Blessing, A., Agbagwa, I.O., Okoli, B.E. Comparative phytochemical screening of Jatropha L. Species in the Niger Delta. research journal of phytochemistry, 2011, vol. 5, no. 2, p. 107–114. DOI: 10.3923/rjphyto.2011.107114.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Substance:
Tannins (RF-00004337-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.2
-
Internal remarks:
Tannins (root)
Composition #14: Nwokocha., Blessing, A., Agbagwa, I.O., Okoli, B.E. Comparative phytochemical screening of Jatropha L. Species in the Niger Delta. research journal of phytochemistry, 2011, vol. 5, no. 2, p. 107–114. DOI: 10.3923/rjphyto.2011.107114.
[
DOI link]
-
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Substance:
Saponins (RF-00004333-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
3.2
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Internal remarks:
Saponins (leaf)
Composition #15: Nwokocha., Blessing, A., Agbagwa, I.O., Okoli, B.E. Comparative phytochemical screening of Jatropha L. Species in the Niger Delta. research journal of phytochemistry, 2011, vol. 5, no. 2, p. 107–114. DOI: 10.3923/rjphyto.2011.107114.
[
DOI link]
-
-
Plant part:
Stem / stalk (as part-nature) (A067S)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Substance:
Saponins (RF-00004333-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
2.7
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Internal remarks:
Saponins (stem)
Composition #16: Nwokocha., Blessing, A., Agbagwa, I.O., Okoli, B.E. Comparative phytochemical screening of Jatropha L. Species in the Niger Delta. research journal of phytochemistry, 2011, vol. 5, no. 2, p. 107–114. DOI: 10.3923/rjphyto.2011.107114.
[
DOI link]
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Substance:
Saponins (RF-00004333-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
2.4
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Internal remarks:
Saponins (seed)
Composition #17: Nwokocha., Blessing, A., Agbagwa, I.O., Okoli, B.E. Comparative phytochemical screening of Jatropha L. Species in the Niger Delta. research journal of phytochemistry, 2011, vol. 5, no. 2, p. 107–114. DOI: 10.3923/rjphyto.2011.107114.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Substance:
Saponins (RF-00004333-PAR)
-
Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
-
Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
2.2
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Internal remarks:
Saponins (root)
Composition #18: Das, Biswanath., Reddy, Kongara Ravinder., Ravikanth, Bommena., Raju, Tuniki Venugopal., Sridhar, Balasubramanian., Khan, Patan Usman., Rao, Janapala Venkateswara. Multifidone: A novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida . bioorganic & medicinal chemistry letters, 2009, vol. 19, no. 1, p. 77–79. DOI: 10.1016/j.bmcl.2008.11.014.
[
DOI link]
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Substance:
Diterpene ketones (RF-00010828-PAR)
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Additional substance description:
citlalitrione, jatrophone, multifidone
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Diterpene ketones
Composition #19: Das, Biswanath., Reddy, Kongara Ravinder., Ravikanth, Bommena., Raju, Tuniki Venugopal., Sridhar, Balasubramanian., Khan, Patan Usman., Rao, Janapala Venkateswara. Multifidone: A novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida . bioorganic & medicinal chemistry letters, 2009, vol. 19, no. 1, p. 77–79. DOI: 10.1016/j.bmcl.2008.11.014.
[
DOI link]
-
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Substance:
coumarins (RF-00004351-PAR)
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Additional substance description:
Cleomiscosin A
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Coumarins
Composition #20: Dougnon, Tamegnon Victorien., Klotoe, Jean Robert., Segbo, Julien., Ategbo, Jean-Marc., Edorh, Aleodjrodo Patrick., Gbaguidi, Fernand., Hounkpatin, Armelle Sabine., Dandjesso, Carlos., Fah, Lauris., Fanou, Brice., Dramane, Karim., Loko, Frederic. Evaluation of the phytochemical and hemostatic potential of Jatropha multifida sap. AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2012, vol. 6, no. 26, p. 1943–1948. DOI: 10.5897/AJPP12.351.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Additional extraction description:
sap from leaves
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Substance:
coumarins (RF-00004351-PAR)
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Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Coumarins (sap from leaves)
Composition #21: Dougnon, Tamegnon Victorien., Klotoe, Jean Robert., Segbo, Julien., Ategbo, Jean-Marc., Edorh, Aleodjrodo Patrick., Gbaguidi, Fernand., Hounkpatin, Armelle Sabine., Dandjesso, Carlos., Fah, Lauris., Fanou, Brice., Dramane, Karim., Loko, Frederic. Evaluation of the phytochemical and hemostatic potential of Jatropha multifida sap. AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2012, vol. 6, no. 26, p. 1943–1948. DOI: 10.5897/AJPP12.351.
[
DOI link]
-
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Plant part:
Leaves (as part-nature) (A0EKT)
-
Additional extraction description:
sap from leaves
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Substance:
Tannins (RF-00004337-PAR)
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Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Tannins (sap from leaves)
Composition #22: Dougnon, Tamegnon Victorien., Klotoe, Jean Robert., Segbo, Julien., Ategbo, Jean-Marc., Edorh, Aleodjrodo Patrick., Gbaguidi, Fernand., Hounkpatin, Armelle Sabine., Dandjesso, Carlos., Fah, Lauris., Fanou, Brice., Dramane, Karim., Loko, Frederic. Evaluation of the phytochemical and hemostatic potential of Jatropha multifida sap. AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2012, vol. 6, no. 26, p. 1943–1948. DOI: 10.5897/AJPP12.351.
[
DOI link]
-
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Additional extraction description:
sap from leaves
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Substance:
anthracene derivatives (RF-00004342-PAR)
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Analytical method code:
Traditional analytical techniques (wet chemical tests) (F003A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Anthracene derivatives (sap from leaves)
Endpoint study
#1: Lurie, Y., Fainmesser, P., Yosef, M., Bentur, Y. Remote identification of poisonous plants by cell-phone camera and online communication. israel medical association journal, 2008, vol. 10, no. 11, p. 802–803. .
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Study relevance:
Human health
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Type of toxicological test:
case report (CHD060TT)
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Limit test:
Not applicable
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-
Route of exposure:
ORAL: FEED (OECD2230PL)
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Number of organisms dosed:
1
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-
Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
Ingestion of 2 fruit caused vomiting and diarrhea
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Effect or parameter linked to the endpoint:
other (CHD003BE)
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Internal remarks:
Vomiting diarrhea, ingestion of 2 fruit, case report
Endpoint study
#2: Butler, J. Toxicology case: Jatropha multifida toxicosis in a dog. veterinary medicine, 2014, vol. 109, no. 6 . .
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
-
Additional plant/substance description:
seeds chewed by dog
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Type of toxicological test:
case report (CHD060TT)
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Limit test:
Not applicable
-
Tested organism:
Dog (as animal) (A0CNL)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
Digestive (TOX18A)
-
Target tissue:
digestive: Liver (TT023A)
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Effect description:
vomiting, diarrhea, elevated liver enzymes
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Effect or parameter linked to the endpoint:
other (CHD003BE)
-
Internal remarks:
Case report dog. Seeds. (vomiting, diarrhea, elevated liver enzymes
Endpoint study
#3: Koltin, D., Uziel, Y., Schneidermann, D., Kotzki, S., Wolach, B., Fainmesser, P. A case of Jatropha multifida poisoning resembling organophosphate intoxication. CLINICAL TOXICOLOGY, 2006, vol. 44, no. 3, p. 337–338. DOI: 10.1080/15563650600584584.
[
DOI link]
-
Study relevance:
Human health
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Type of toxicological test:
case report (CHD060TT)
-
Limit test:
Not applicable
-
Tested organism:
Human (as organism) (A056J)
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
Number of organisms dosed:
4
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
Digestive (TT002A)
-
Effect description:
Vomiting, watery diarrhea. Miosis. Obtundation in 2 individuals.
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Effect or parameter linked to the endpoint:
other (CHD003BE)
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Internal remarks:
Vomiting, watery diarrhea. Miosis.
Genotox #1: van den Bout-van den Beukel, Carolien J. P., Hamza, Omar J. M., Moshi, Mainen J., Matee, Mecky I. N., Mikx, Frans., Burger, David M., Koopmans, Peter P., Verweij, Paul E., Schoonen, Willem G. E. J., van der Ven, Andre J. A. M. Evaluation of cytotoxic, genotoxic and CYP450 enzymatic competition effects of tanzanian plant extracts traditionally used for treatment of fungal infections . basic & clinical pharmacology & toxicology, 2008, vol. 102, no. 6, p. 515–526. DOI: 10.1111/j.1742-7843.2008.00225.x.
[
DOI link]
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Study category:
Mutagenicity
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Type of toxicological test:
bacterial gene mutation assay (CHD027TT)
-
-
Guideline used:
No guideline required
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Tested organism:
Salmonella typhimurium (as organism) (A0CPZ)
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Exogenous metabolic activation applied:
with and without
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Endpoint measured:
gene mutation
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-
Remarks on genotox study:
Vitotox test
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Internal remarks:
Genotoxic as shown by Vitotox test
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Internal ID:
WOS:000255909400004