EFSA Compendium of Botanicals

Draft - work in progress

Jatropha integerrima Jacq. // Jatropha hastata Jacq. // Jatropha pandurifolia Andrews

Family:: Euphorbiaceae
Approval state:: Approved
Number of articles retrieved:: 81
Number of processed references:: 9

Compositions

#1: phorbol esters (leaves) #2: Alkaloids #3: scopoletin #4: Diterpene ketones #5: Diterpene ketones #6: 1,8-cineol (seed ess oil with fat) #7: 1.8-cineole (leaf oil) #8: 1,8-cineole (seed ess oil without fat) #9: jatrophadioxan (roots, coumarins) #10: lignans (jatrointelignans A-D, schisphenlignan I) #11: Phorbol esters (seed) #12: Diterpene ketones

Endpoint Studies

Genotoxicity

Composition #1: Ohike, Tatsuya., Matsukawa, Tetsuya., Okanami, Masahiro., Ano, Takashi., Kajiyama, Shin-ichiro. Distributional analysis of phorbol esters in J. curcas and J. integerrima. memoirs of the school of biology-oriented science and technology of kinki university, 2011, p. 29–38. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Additional extraction description:

unspecified
Substance:

Phorbol esters (RF-00004310-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

phorbol esters (leaves)

Composition #2: Coe, Felix G., Parikh, Dimpi M., Johnson, Caley A., Anderson, Gregory J. The good and the bad: Alkaloid screening and brineshrimp bioassays of aqueous extracts of 31 medicinal plants of eastern Nicaragua. pharmaceutical biology (london, united kingdom), 2012, p. 384–392. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform/methanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #3: Zohora, F. T., Sarkar, P., Tareq, F. S., Islam, F., Hasan, C. M., Ahsan, M. Isolation of terpenes and coumarin from the stem bark of Jatropha pandurifolia (Andr.). asian journal of chemistry, 2013, p. 2853–2856. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

H NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

scopoletin

Composition #4: Zohora, F. T., Sarkar, P., Tareq, F. S., Islam, F., Hasan, C. M., Ahsan, M. Isolation of terpenes and coumarin from the stem bark of Jatropha pandurifolia (Andr.). asian journal of chemistry, 2013, p. 2853–2856. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Diterpene ketones (RF-00010828-PAR)
Additional substance description:

jatropholone A, 2alpha-hydroxyjatropholone
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

H NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Diterpene ketones

Composition #5: Sutthivaiyakit, S., Mongkolvisut, W., Ponsitipiboon, P., Prabpai, S., Kongsaeree, P., Ruchirawat, S., Mahidol, C. A novel 8,9-seco-rhamnofolane and a new rhamnofolane endoperoxide from Jatropha integerrima roots. TETRAHEDRON LETTERS, 2003, vol. 44, no. 18, p. 3637–3640. DOI: 10.1016/S0040-4039(03)00704-4. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

Diterpene ketones (RF-00010828-PAR)
Additional substance description:

caniojane
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Diterpene ketones

Composition #6: Eshilokun, Adeolu O., Kasali, Adeleke A., Ogunwande, Isiaka A., Walker, Tameka M., Setzer, Williams N. Chemical composition and antimicrobial studies of the essential oils of Jatropha integerrima Jacq (leaf and seeds) . natural product communications, 2007, vol. 2, no. 8, p. 853–855. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation, oil with fat component
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.4
Internal remarks:

1,8-cineol (seed ess oil with fat)

Composition #7: Eshilokun, Adeolu O., Kasali, Adeleke A., Ogunwande, Isiaka A., Walker, Tameka M., Setzer, Williams N. Chemical composition and antimicrobial studies of the essential oils of Jatropha integerrima Jacq (leaf and seeds) . natural product communications, 2007, vol. 2, no. 8, p. 853–855. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

11.2
Internal remarks:

1.8-cineole (leaf oil)

Composition #8: Eshilokun, Adeolu O., Kasali, Adeleke A., Ogunwande, Isiaka A., Walker, Tameka M., Setzer, Williams N. Chemical composition and antimicrobial studies of the essential oils of Jatropha integerrima Jacq (leaf and seeds) . natural product communications, 2007, vol. 2, no. 8, p. 853–855. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation, oil without fat component
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (Q) (F344A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

35.8
Internal remarks:

1,8-cineole (seed ess oil without fat)

Composition #9: Sutthivaiyakit, Somyote., Mongkolvisut, Wantana., Prabpai, Samran., Kongsaeree, Palangpon. Diterpenes, Sesquiterpenes, and a Sesquiterpene-Coumarin Conjugate from Jatropha integerrima. JOURNAL OF NATURAL PRODUCTS, 2009, vol. 72, no. 11, p. 2024–2027. DOI: 10.1021/np900342b. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, CH2Cl2, and MeOH
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

jatrophadioxan (sesquiterpene-coumarin conjugate)
Analytical method - additional description:

X-ray crystallography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

jatrophadioxan (roots, coumarins)

Composition #10: Zhu, Jian-Yong., Cheng, Bao., Zheng, Yin-Jia., Dong, Zhen., Lin, Shu-Ling., Tang, Gui-Hua., Gu, Qiong., Yin, Sheng. Enantiomeric neolignans and sesquineolignans from Jatropha integerrima and their absolute configurations. RSC ADVANCES, 2015, vol. 5, no. 16, p. 12202–12208. DOI: 10.1039/c4ra15966g. [DOI link]

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

jatrointelignans A-D, schisphenlignan I
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lignans (jatrointelignans A-D, schisphenlignan I)

Composition #11: One, Khin Thida., Muakrong, Narathid., Tanya, Patcharin., Valette, Jeremy., Girard, Philippe., Srinives, Peerasak. Physicochemical properties of seeds and oil from an F2 population of Jatropha curcas x Jatropha integerrima . scienceasia, 2014, vol. 40, no. 6, p. 428–435. DOI: 10.2306/scienceasia1513-1874.2014.40.428. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

Phorbol esters (RF-00004310-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Milligram/gram (G060A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.92
Internal remarks:

Phorbol esters (seed)

Composition #12: Zhu, Jian-Yong., Lou, Lan-Lan., Guo, Yan-Qiong., Li, Wei., Guo, Yan-Hong., Bao, Jing-Mei., Tang, Gui-Hua., Bu, Xian-Zhang., Yin, Sheng. Natural thioredoxin reductase inhibitors from Jatropha integerrima. rsc advances, 2015, vol. 5, no. 58, p. 47235–47243. DOI: 10.1039/c5ra07274c. [DOI link]

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

Diterpene ketones (RF-00010828-PAR)
Additional substance description:

curcusone A-D, jatrointelones A to I
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Diterpene ketones