EFSA Compendium of Botanicals

Draft - work in progress

Jatropha gossypiifolia L.

Family:: Euphorbiaceae
Approval state:: Approved
Number of articles retrieved:: 173
Number of processed references:: 10

Compositions

#1: jatrophone #2: Tannins #3: Diterpene ketones #4: Lignans #5: Coumarins #6: Alkaloids

Endpoint Studies

#1: digestive, lung and heart disturbances leading to death #2: Antifertility effect #3: Neurotoxicity #4: Reduction of the systolic blood pressure. #5: Mortality #6: pulmonary toxicity #7: Nephrotoxicity #8: Hepatotoxicity

Genotoxicity

#1: Jatropha (ethanol extract and latex) exhibited significantly higher DNA damage in their blood cell erythrocytes as compared to the control

Composition #1: Kupchan, S. Morris., Sigel, Carl W., Matz, Marilyn J., Gilmore, Christopher J., Bryan, Robert F. Tumor inhibitors. 111. Structure and stereochemistry of jatrophone, a novel macrocyclic diterpenoid tumor inhibitor. Journal of the American Chemical Society, 1976, p. 2295–2300. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol (95%)
Substance:

jatrophone (RF-00011469-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

jatrophone

Composition #2: Felix-Silva, Juliana., Souza, Thiago., Menezes, Yamara A. S., Cabral, Barbara., Camara, Rafael B. G., Silva, Arnobio A., Rocha, Hugo A. O., Rebecchi, Ivanise M. M., Zucolotto, Silvana M., Fernandes-Pedrosa, Matheus F. Aqueous leaf extract of Jatropha gossypiifolia L. (Euphorbiaceae) inhibits enzymatic and biological actions of Bothrops jararaca snake venom. plos one, 2014, p. e104952/1–e104952/14. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #3: Zhang, X.-P., Zhang, M.-L., Su, X.-H., Huo, C.-H., Gu, Y.-C., Shi, Q.-W. Chemical constituents of the plants from genus Jatropha. chemistry and biodiversity, 2009, vol. 6, no. 12, p. 2166–2183. DOI: 10.1002/cbdv.200700461. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Additional extraction description:

unspecified
Substance:

Diterpene ketones (RF-00010828-PAR)
Additional substance description:

Citlalitrione, jatrophatrione
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Diterpene ketones

Composition #4: Zhang, X.-P., Zhang, M.-L., Su, X.-H., Huo, C.-H., Gu, Y.-C., Shi, Q.-W. Chemical constituents of the plants from genus Jatropha. chemistry and biodiversity, 2009, vol. 6, no. 12, p. 2166–2183. DOI: 10.1002/cbdv.200700461. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Additional extraction description:

unspecified
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

Gadain, prasanthaline, gossypidien
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans

Composition #5: Zhang, X.-P., Zhang, M.-L., Su, X.-H., Huo, C.-H., Gu, Y.-C., Shi, Q.-W. Chemical constituents of the plants from genus Jatropha. chemistry and biodiversity, 2009, vol. 6, no. 12, p. 2166–2183. DOI: 10.1002/cbdv.200700461. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Additional extraction description:

unspecified
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

Scopoletin, fraxetin, Cleomiscosin A
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins

Composition #6: Coe, F.G., Parikh, D.M., Johnson, C.A. Alkaloid presence and brine shrimp (Artemia salina) bioassay of medicinal species of eastern Nicaragua. Pharmaceutical Biology, 2010, vol. 48, no. 4, p. 439–445. DOI: 10.3109/13880200903168015. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3 -MeOH
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Endpoint study #1: Oliveira, L.I., Jabour, F.F., Nogueira, V.A., Yamasaki, E.M. Experimental poisoning by the leaves of Jatropha gossypifolia (Euphorbiaceae) in sheep Intoxicação experimental com as folhas de Jatropha gossypifolia (Euphorbiaceae) em ovinos . pesquisa veterinaria brasileira, 2008, vol. 28, no. 6, p. 275–278. .

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Fresh (A166Y)
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

Sheep (as animal) (A057G)
Route of exposure:

ORAL: FEED (OECD2230PL)
Unit of exposure duration:

single (food/feed) (G203A)
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Gram/kilogram (G015A)
Effect concentration:

40
Critical effect:

SYSTEMIC (TOX01A)
Target tissue:

cardiovascular / haematological: Heart (TT011A)
Effect description:

digestive, lung and heart disturbances leading to death
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

digestive, lung and heart disturbances leading to death

Endpoint study #2: Jain, S., Choudhary, G.P., Jain, D.K. Pharmacological evaluation of anti-fertility activity of ethanolic extract of Jatropha gossypifolia leaf in female albino mice. asian pacific journal of tropical biomedicine, 2012, vol. 2, no. 3 SUPPL., p. S1671–S1674. DOI: 10.1016/S2221-1691(12)60475-4. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanolic
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

21.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

5
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

250
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

Urogenital (TT006A)
Effect description:

Antifertility effect - prolonged estrous cycle with significant increase in the duration of diestrus phase and elongation of estrus stage in treatment with higher dose (450 mg/kg body weight/day).
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Antifertility effect

Endpoint study #3: Mariz, Saulo R., Cerqueira, Gilberto S., Araújo, Washington C., Duarte, José C., Melo, Arquimedes F.M., Santos, Hosana B., Oliveira, Kardilândia., Diniz, Margareth F.F. Melo., Medeiros, Isac A. Estudo toxicológico agudo do extrato etanólico de partes aéreas de Jatropha gossypiifolia L. em ratos . revista brasileira de farmacognosia, 2006, vol. 16, no. 3, p. 372–378. DOI: 10.1590/S0102-695X2006000300015. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanolic
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Unit of exposure duration:

single (food/feed) (G203A)
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Gram/kilogram (G015A)
Effect concentration:

1.2-5
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

Neurologic (TT004A)
Effect description:

ptosis and hindlimb paralysis
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

Neurotoxicity

Endpoint study #4: Abreu, IC., Marinho, ASS., Paes, AMA., Freire, SMF., Olea, RSG., Borges, MOR., Borges, ACR. Hypotensive and vasorelaxant effects of ethanolic extract from Jatropha gossypiifolia L. in rats . fitoterapia, 2003, vol. 74, no. 7-8, p. 650–657. DOI: 10.1016/j.fitote.2003.07.002. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Ethanol (95%)
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

4.0
Unit of exposure duration:

Week (G205A)
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

125-250
Critical effect:

PULMONARY AND CARDIAC (TOX08A)
Target tissue:

cardiovascular / haematological: Heart (TT011A)
Effect description:

11-13.3% reduction of the systolic blood pressure.
Effect or parameter linked to the endpoint:

other (CHD003BE)
Internal remarks:

Reduction of the systolic blood pressure.

Endpoint study #5: Mariz, Saulo R., Cerqueira, Gilberto S., Araujo, Washington C., Dantas, Jadson G., Ramalho, Josue A., Palomaro, Thayse V., Duarte, Jose C., dos Santos, Hosana B., Olveira, Kardilandia., de Araujo, Maria Salete T., Diniz, Margareth de F. F. M., de Medeiros, Isac A. Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2012, vol. 22, no. 3, p. 663–668. DOI: 10.1590/S0102-695X2012005000024. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanolic
Type of toxicological test:

chronic/long term toxicity (CHD004TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male/Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

13.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

5
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

135
Critical effect:

SYSTEMIC (TOX01A)
Effect description:

mortality of 13.3% in both males and females groups.
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

Mortality

Endpoint study #6: Mariz, Saulo R., Cerqueira, Gilberto S., Araujo, Washington C., Dantas, Jadson G., Ramalho, Josue A., Palomaro, Thayse V., Duarte, Jose C., dos Santos, Hosana B., Olveira, Kardilandia., de Araujo, Maria Salete T., Diniz, Margareth de F. F. M., de Medeiros, Isac A. Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2012, vol. 22, no. 3, p. 663–668. DOI: 10.1590/S0102-695X2012005000024. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanolic
Type of toxicological test:

chronic/long term toxicity (CHD004TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

13.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

5
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

405
Critical effect:

PULMONARY AND CARDIAC (TOX08A)
Target tissue:

respiratory: Lung (TT041A)
Effect description:

Lungs of animals treated with the dose of 405 mg/kg were damaged through an inflammatory response and stimulation of the immunitary system
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

pulmonary toxicity

Endpoint study #7: Mariz, Saulo R., Cerqueira, Gilberto S., Araujo, Washington C., Dantas, Jadson G., Ramalho, Josue A., Palomaro, Thayse V., Duarte, Jose C., dos Santos, Hosana B., Olveira, Kardilandia., de Araujo, Maria Salete T., Diniz, Margareth de F. F. M., de Medeiros, Isac A. Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2012, vol. 22, no. 3, p. 663–668. DOI: 10.1590/S0102-695X2012005000024. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanolic
Type of toxicological test:

chronic/long term toxicity (CHD004TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

13.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

5
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

135
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

renal toxicity ( dark spots, sign of necrotizing action)
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

Nephrotoxicity

Endpoint study #8: Mariz, Saulo R., Cerqueira, Gilberto S., Araujo, Washington C., Dantas, Jadson G., Ramalho, Josue A., Palomaro, Thayse V., Duarte, Jose C., dos Santos, Hosana B., Olveira, Kardilandia., de Araujo, Maria Salete T., Diniz, Margareth de F. F. M., de Medeiros, Isac A. Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2012, vol. 22, no. 3, p. 663–668. DOI: 10.1590/S0102-695X2012005000024. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanolic
Type of toxicological test:

chronic/long term toxicity (CHD004TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

13.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

5
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

405
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

liver toxicity ( dark spots, sign of necrotizing action)
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

Hepatotoxicity

Genotox #1: Singh, P., Dabas, A., Srivastava, R., Nagpure, N.S., Singh, A. Evaluation of genotoxicity induced by medicinal plant Jatropha gossypifolia in freshwater fish Channa punctatus (Bloch). Turkish Journal of Fisheries and Aquatic Sciences, 2014, vol. 14, no. 2, p. 421–428. DOI: 10.4194/1303-2712-v14_2_12. [DOI link]

Study category:

Genotoxicity
Type of toxicological test:

micronucleus assay (CHD051TT)
Method type:

in vivo
Guideline used:

According to
Tested organism:

Other (A07XE)
Sex:

No data
Exogenous metabolic activation applied:

no data
Route of exposure:

OTHER (OECD0PL)
Exposure duration for in vivo:

96.0
Unit of exposure duration:

Hour (G099A)
Number of organisms dosed:

5
Control groups used:

yes
Endpoint measured:

DNA damage and/or repair
Is genotoxic:

Positive
Remarks on genotox study:

Jatropha exhibited significantly higher DNA damage in their blood cell erythrocytes as compared to the control
Internal remarks:

Jatropha (ethanol extract and latex) exhibited significantly higher DNA damage in their blood cell erythrocytes as compared to the control
Internal ID:

eid=2-s2.0-84907816590