EFSA Compendium of Botanicals

Draft - work in progress

Jacobaea maritima (L.) Pelser & Meijden // Cineraria maritima (L.) L. // Senecio bicolor subsp. cineraria (DC.) Chater // Senecio cineraria DC.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 55
Number of processed references:: 5

Compositions

#1: Isopimpinellin #2: Esculetin #3: Marmesin #4: Xanthotoxin #5: Unsaturated pyrrolizidine alkaloids #6: Unsaturated pyrrolizidine alkaloids (total aerial parts) #7: Unsaturated pyrrolizidine alkaloids (total roots) #8: Florosenine #9: Otosenine #10: Floridanine #11: Doronine #12: Senecionine

Endpoint Studies

Genotoxicity

Composition #1: Grace, Mary H., Khattab, Awatif M. Chemical constituents and molluscicidal activity of Senecio cineraria D.C . egyptian journal of pharmaceutical sciences, 1998, vol. 39, no. 1-3, p. 253–266. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Isopimpinellin (RF-00003784-PAR)
Additional substance description:

furanocoumarins
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isopimpinellin

Composition #2: Grace, Mary H., Khattab, Awatif M. Chemical constituents and molluscicidal activity of Senecio cineraria D.C . egyptian journal of pharmaceutical sciences, 1998, vol. 39, no. 1-3, p. 253–266. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Esculetin (RF-00003667-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Esculetin

Composition #3: Grace, Mary H., Khattab, Awatif M. Chemical constituents and molluscicidal activity of Senecio cineraria D.C . egyptian journal of pharmaceutical sciences, 1998, vol. 39, no. 1-3, p. 253–266. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

marmesin (RF-00003917-PAR)
Additional substance description:

furanocoumarins
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Marmesin

Composition #4: Grace, Mary H., Khattab, Awatif M. Chemical constituents and molluscicidal activity of Senecio cineraria D.C . egyptian journal of pharmaceutical sciences, 1998, vol. 39, no. 1-3, p. 253–266. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Methoxsalen Methoxsalen (RF-00003863-PAR)
Additional substance description:

Xanthotoxin
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Xanthotoxin

Composition #5: Wiedenfeld, H., Montes, C., Tawil, B., Contin, A., Wynsma, R. Pyrrolizidine alkaloid level in Senecio bicolor (Willd.) Tod, ssp. cineraria (DC.) from Middle Europe. pharmazie, 2006, p. 559–561. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2Cl2––MeOH––NH4OH
Substance:

Unsaturated pyrrolizidine alkaloids (RF-00004340-PAR)
Additional substance description:

Senecionine, integerrimine, seneciphylline, jacobine, jacoline, jaconine and jacobine-acetate
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Unsaturated pyrrolizidine alkaloids

Composition #6: El-Shazly, A. Pyrrolizidine alkaloid profiles of some Senecio species from Egypt. zeitschrift fur naturforschung c-a journal of biosciences, 2002, vol. 57, no. 5-6, p. 429–433. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ch2Cl2
Substance:

Unsaturated pyrrolizidine alkaloids (RF-00004340-PAR)
Additional substance description:

total alkaloids
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.2-2.3
Internal remarks:

Unsaturated pyrrolizidine alkaloids (total aerial parts)

Composition #7: El-Shazly, A. Pyrrolizidine alkaloid profiles of some Senecio species from Egypt. zeitschrift fur naturforschung c-a journal of biosciences, 2002, vol. 57, no. 5-6, p. 429–433. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ch2Cl2
Substance:

Unsaturated pyrrolizidine alkaloids (RF-00004340-PAR)
Additional substance description:

total alkaloids
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.2
Internal remarks:

Unsaturated pyrrolizidine alkaloids (total roots)

Composition #8: Tundis, Rosa., Loizzo, Monica R., Statti, Giancarlo A., Passalacqua, Nicodemo G., Peruzzi, Lorenzo., Menichini, Francesco. Pyrrolizidine alkaloid profiles of the Senecio cineraria group (Asteraceae) . zeitschrift fur naturforschung c-a journal of biosciences, 2007, vol. 62, no. 7-8, p. 467–472. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Florosenine (RF-00000394-TOX)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

GLC-MS
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

32.4
Internal remarks:

Florosenine

Composition #9: Tundis, Rosa., Loizzo, Monica R., Statti, Giancarlo A., Passalacqua, Nicodemo G., Peruzzi, Lorenzo., Menichini, Francesco. Pyrrolizidine alkaloid profiles of the Senecio cineraria group (Asteraceae) . zeitschrift fur naturforschung c-a journal of biosciences, 2007, vol. 62, no. 7-8, p. 467–472. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Otosenine (RF-00000292-TOX)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

GLC-MS
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

23.6
Internal remarks:

Otosenine

Composition #10: Tundis, Rosa., Loizzo, Monica R., Statti, Giancarlo A., Passalacqua, Nicodemo G., Peruzzi, Lorenzo., Menichini, Francesco. Pyrrolizidine alkaloid profiles of the Senecio cineraria group (Asteraceae) . zeitschrift fur naturforschung c-a journal of biosciences, 2007, vol. 62, no. 7-8, p. 467–472. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Floridanine (RF-00000393-TOX)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

GLC-MS
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.9
Internal remarks:

Floridanine

Composition #11: Tundis, Rosa., Loizzo, Monica R., Statti, Giancarlo A., Passalacqua, Nicodemo G., Peruzzi, Lorenzo., Menichini, Francesco. Pyrrolizidine alkaloid profiles of the Senecio cineraria group (Asteraceae) . zeitschrift fur naturforschung c-a journal of biosciences, 2007, vol. 62, no. 7-8, p. 467–472. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Doronine (RF-00000275-TOX)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

GLC-MS
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.4
Internal remarks:

Doronine

Composition #12: ADAMS, R., GOVINDACHARI, TR. SENECIO ALKALOIDS - THE ISOLATION OF SENECIONINE FROM SENECIO-CINERARIA AND SOME OBSERVATIONS ON THE STRUCTURE OF SENECIONINE. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1949, vol. 71, no. 6, p. 1953–1956. DOI: 10.1021/ja01174a014. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

Senecionine (RF-00000232-TOX)
Analytical method code:

IR and Raman Spectroscopy (F010A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Senecionine