EFSA Compendium of Botanicals

Draft - work in progress

Inula britannica L.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 409
Number of processed references:: 5

Compositions

#1: Coumarins (esculetin, scopoletin) #2: Protocatechuic acid #3: Salicylic acid #4: p-hydroxybenzoic acid #5: Coumaric acid #6: Berberine #7: Guaianolides (Ergolide,8-epi-helenalin, bigelovin) #8: Hydroxy alantolactone and 8-epi-ivangustin #9: guaianolides (11,13-dihydroinuchinenolide B, 4H-tomentosin, pulchellin C, gaillardin, britannin and derivatives) #10: Sesquiterpene lactones type eudesmanolide (Britannilactone and derivatives, granillin and derivatives)

Endpoint Studies

Genotoxicity

Composition #1: Krolikowska, Maria., Wolbis, Maria. Polyphenolic compounds in Inula britannica. acta poloniae pharmaceutica, 1981, p. 107–114. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

unspecified
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

esculetin, scopoletin
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins (esculetin, scopoletin)

Composition #2: Krolikowska, Maria., Wolbis, Maria. Polyphenolic compounds in Inula britannica. acta poloniae pharmaceutica, 1981, p. 107–114. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

unspecified
Substance:

3,4-Dihydroxybenzoic acid (RF-00008853-PAR)
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Protocatechuic acid

Composition #3: Krolikowska, Maria., Wolbis, Maria. Polyphenolic compounds in Inula britannica. acta poloniae pharmaceutica, 1981, p. 107–114. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

unspecified
Substance:

Salicylic acid (RF-00000241-VET)
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Salicylic acid

Composition #4: Krolikowska, Maria., Wolbis, Maria. Polyphenolic compounds in Inula britannica. acta poloniae pharmaceutica, 1981, p. 107–114. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

unspecified
Substance:

4-Hydroxybenzoic acid (RF-00008325-PAR)
Additional substance description:

p-hydroxybenzoic acid
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

p-hydroxybenzoic acid

Composition #5: Krolikowska, Maria., Wolbis, Maria. Polyphenolic compounds in Inula britannica. acta poloniae pharmaceutica, 1981, p. 107–114. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

unspecified
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumaric acid

Composition #6: Geng, Hongmei. Chemical constituents of Inula Britannica. shizhen guoyi guoyao, 2008, p. 2432–2433. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Berberine

Composition #7: Park, EJ., Kim, J. Cytotoxic sesquiterpene lactones from Inula britannica. planta medica, 1998, vol. 64, no. 8, p. 752–754. DOI: 10.1055/s-2006-957573. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

guaianolides (RF-00010821-PAR)
Additional substance description:

Ergolide, 8-epi-helenalin, bigelovin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR; UV; HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Guaianolides (Ergolide,8-epi-helenalin, bigelovin)

Composition #8: Qi, Jin-Long., Fu, Yan., Shi, Xiao-Wei., Wu, Yi-Bing., Wang, Yun-Zhi., Zhang, Di-Qun., Shi, Qing-Wen. Sesquiterpene Lactones and their Anti-Tumor Activity from the Flowers of Inula Britannica . letters in drug design & discovery, 2008, vol. 5, no. 7, p. 433–436. DOI: 10.2174/157018008785909813. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Additional extraction description:

unspecified
Substance:

sesquiterpene lactones type eudesmanolide sesquiterpene lactones type eudesmanolide (RF-00004395-PAR)
Additional substance description:

Hydroxy alantolactone and 8-epi-ivangustin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, MS and a series of 1D and 2D NMR analyses
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Hydroxy alantolactone and 8-epi-ivangustin

Composition #9: Fischedick, Justin T., Pesic, Milica., Podolski-Renic, Ana., Bankovic, Jasna., de Vos, Ric C. H., Peric, Marija., Todorovic, Slapana., Tanic, Nikola. Cytotoxic activity of sesquiterpene lactones from Inula britannica on human cancer cell lines . phytochemistry letters, 2013, vol. 6, no. 2, p. 246–252. DOI: 10.1016/j.phytol.2013.02.006. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

guaianolides (RF-00010821-PAR)
Additional substance description:

11,13-dihydroinuchinenolide B, 4H-tomentosin, pulchellin C, gaillardin, britannin and derivatives
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR; HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

guaianolides (11,13-dihydroinuchinenolide B, 4H-tomentosin, pulchellin C, gaillardin, britannin and derivatives)

Composition #10: Fischedick, Justin T., Pesic, Milica., Podolski-Renic, Ana., Bankovic, Jasna., de Vos, Ric C. H., Peric, Marija., Todorovic, Slapana., Tanic, Nikola. Cytotoxic activity of sesquiterpene lactones from Inula britannica on human cancer cell lines . phytochemistry letters, 2013, vol. 6, no. 2, p. 246–252. DOI: 10.1016/j.phytol.2013.02.006. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

sesquiterpene lactones type eudesmanolide sesquiterpene lactones type eudesmanolide (RF-00004395-PAR)
Additional substance description:

Britannilactone and derivatives, granillin and derivatives
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR; HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene lactones type eudesmanolide (Britannilactone and derivatives, granillin and derivatives)