EFSA Compendium of Botanicals

Draft - work in progress

Hyptis verticillata Jacq.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 62
Number of processed references:: 4

Compositions

#1: isocaryophyllene, 5,6-epoxide #2: cedrene epoxide #3: Podophyllotoxin #4: beta-apopicropodophyllin #5: hyptinin #6: Epipodorhizol

Endpoint Studies

Genotoxicity

Composition #1: Pino, Jorge A., Bello, Avilio., Urquiola, Armando., Marbot, Rolando. Essential oil of Hyptis verticillata Jacq. from Cuba. revista cenic, ciencias quimicas, 2002, p. 55–56. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

isocaryophyllene, 5,6-epoxide (RF-00011474-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

14.4
Internal remarks:

isocaryophyllene, 5,6-epoxide

Composition #2: Facey, PC., Porter, RBR., Reese, PB., Williams, LAD. Biological activity and chemical composition of the essential oil from Jamaican Hyptis verticillata Jacq. . journal of agricultural and food chemistry, 2005, vol. 53, no. 12, p. 4774–4777. DOI: 10.1021/jf050008y. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

cedrene epoxide (RF-00011473-PAR)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.3
Internal remarks:

cedrene epoxide

Composition #3: NOVELO, M., CRUZ, JG., HERNANDEZ, L., PEREDMIRANDA, R., CHAI, HY., MAR, W., PEZZUTO, JM. CYTOTOXIC CONSTITUENTS FROM HYPTIS-VERTICILLATA .6. CHEMICAL STUDIES ON MEXICAN HYPTIS SPECIES AND .2. BIOLOGICALLY-ACTIVE NATURAL-PRODUCTS FROM MEXICAN MEDICINAL-PLANTS . journal of natural products, 1993, vol. 56, no. 10, p. 1728–1736. DOI: 10.1021/np50100a011. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane and chloroform
Substance:

podophyllotoxin (RF-00004001-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Podophyllotoxin

Composition #4: NOVELO, M., CRUZ, JG., HERNANDEZ, L., PEREDMIRANDA, R., CHAI, HY., MAR, W., PEZZUTO, JM. CYTOTOXIC CONSTITUENTS FROM HYPTIS-VERTICILLATA .6. CHEMICAL STUDIES ON MEXICAN HYPTIS SPECIES AND .2. BIOLOGICALLY-ACTIVE NATURAL-PRODUCTS FROM MEXICAN MEDICINAL-PLANTS . journal of natural products, 1993, vol. 56, no. 10, p. 1728–1736. DOI: 10.1021/np50100a011. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane and chloroform
Substance:

picropodophyllin (RF-00011091-PAR)
Additional substance description:

beta-apopicropodophyllin
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

beta-apopicropodophyllin

Composition #5: KUHNT, M., RIMPLER, H., HEINRICH, M. LIGNANS AND OTHER COMPOUNDS FROM THE MIXE-INDIAN MEDICINAL PLANT HYPTIS-VERTICILLATA. PHYTOCHEMISTRY, 1994, vol. 36, no. 2, p. 485–489. DOI: 10.1016/S0031-9422(00)97101-2. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone/water
Substance:

hyptinin (RF-00011387-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

optical rotation, UV, IR, NMR, MS, CD
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

hyptinin

Composition #6: KUHNT, M., RIMPLER, H., HEINRICH, M. LIGNANS AND OTHER COMPOUNDS FROM THE MIXE-INDIAN MEDICINAL PLANT HYPTIS-VERTICILLATA. PHYTOCHEMISTRY, 1994, vol. 36, no. 2, p. 485–489. DOI: 10.1016/S0031-9422(00)97101-2. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone/water
Substance:

epipodorhizol (RF-00011077-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

optical rotation, UV, IR, NMR, MS, CD
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Epipodorhizol