EFSA Compendium of Botanicals

Draft - work in progress

Hyoscyamus niger L.

Family:: Solanaceae
Approval state:: Approved
Number of articles retrieved:: 785
Number of processed references:: 2

Compositions

#1: Tropane alkaloids #2: Lignans #3: Saponins #4: Lignanamides

Endpoint Studies

Genotoxicity

Composition #1: Alizadeh, Anahita., Moshiri, Mohammad., Alizadeh, Javad., Balali-Mood, Mahdi. Black henbane and its toxicity - a descriptive review.. avicenna journal of phytomedicine, 2014, vol. 4, no. 5, p. 297–311. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Tropane alkaloids (RF-00000245-TOX)
Additional substance description:

Hyoscyamine, Atropine, Tropane and Scopolamine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tropane alkaloids

Composition #2: Alizadeh, Anahita., Moshiri, Mohammad., Alizadeh, Javad., Balali-Mood, Mahdi. Black henbane and its toxicity - a descriptive review.. avicenna journal of phytomedicine, 2014, vol. 4, no. 5, p. 297–311. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

lignans (RF-00004361-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans

Composition #3: Alizadeh, Anahita., Moshiri, Mohammad., Alizadeh, Javad., Balali-Mood, Mahdi. Black henbane and its toxicity - a descriptive review.. avicenna journal of phytomedicine, 2014, vol. 4, no. 5, p. 297–311. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #4: Ma, CY., Liu, WK., Che, CT. Lignanamides and nonalkaloidal components of Hyoscyamus niger seeds. journal of natural products, 2002, vol. 65, no. 2, p. 206–209. DOI: 10.1021/np010073b. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

lignanamides
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignanamides

Endpoint study #1: Alizadeh, Anahita., Moshiri, Mohammad., Alizadeh, Javad., Balali-Mood, Mahdi. Black henbane and its toxicity - a descriptive review.. avicenna journal of phytomedicine, 2014, vol. 4, no. 5, p. 297–311. .

Study relevance:

Human health
Substance:

Tropane alkaloids (RF-00000245-TOX)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Male/Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Central Nervous System (TT035A)
Effect description:

From CNS excitation dry mouth, slurred speech, difficulty in speaking, dysphagia, warm flushed skin, pyrexia, nausea, vomiting to severe intoxication accompanied with hypertension, respiratory arrest, coma and convulsions
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

neurotoxicity