EFSA Compendium of Botanicals

Draft - work in progress

Hyoscyamus albus L.

Family:: Solanaceae
Approval state:: Approved
Number of articles retrieved:: 121
Number of processed references:: 3

Compositions

#1: Alkaloids #2: Saponins #3: Tannins #4: Tropane alkaloids

Endpoint Studies

#1: mydriasis, dry mouth and pharynx, abdominal pains, nausea without vomiting #2: Nephrotoxicity

Genotoxicity

Composition #1: Benhouda, A., Yahia, M. Toxicity, analgesic and anti-pyretic activities of methanolic extract from hyoscyamus albus' leaves in albinos rats. international journal of pharmacy and pharmaceutical sciences, 2014, vol. 6, no. 3, p. 121–127. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #2: Benhouda, A., Yahia, M. Toxicity, analgesic and anti-pyretic activities of methanolic extract from hyoscyamus albus' leaves in albinos rats. international journal of pharmacy and pharmaceutical sciences, 2014, vol. 6, no. 3, p. 121–127. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #3: Benhouda, A., Yahia, M. Toxicity, analgesic and anti-pyretic activities of methanolic extract from hyoscyamus albus' leaves in albinos rats. international journal of pharmacy and pharmaceutical sciences, 2014, vol. 6, no. 3, p. 121–127. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #4: DOERKSCHMITZ, K., WITTE, L., ALFERMANN, AW. TROPANE ALKALOID PATTERNS IN PLANTS AND HAIRY ROOTS OF HYOSCYAMUS-ALBUS. phytochemistry, 1994, vol. 35, no. 1, p. 107–110. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

0.1 N H2SO4, 25% NH3
Substance:

Tropane alkaloids (RF-00000245-TOX)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tropane alkaloids

Endpoint study #1: Paravisiliu, Marie., Constantellos, B. Food intoxication by white henbane. annales pharmaceutiques francaises, 1947, p. 109–111. .

Study relevance:

Human health
Substance:

Hyoscyamine (RF-00000247-TOX)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Thermal treatment (heating for preservation) (A07HR)
Additional plant/substance description:

boiled herbs
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Male/Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

1.0
Unit of exposure duration:

Meal (G109A)
Number of organisms dosed:

15
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

Neurologic (TT004A)
Effect description:

mydriasis, dry mouth and pharynx, abdominal pains, nausea without vomiting
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

mydriasis, dry mouth and pharynx, abdominal pains, nausea without vomiting

Endpoint study #2: Benhouda, A., Yahia, M. Toxicity, analgesic and anti-pyretic activities of methanolic extract from hyoscyamus albus' leaves in albinos rats. international journal of pharmacy and pharmaceutical sciences, 2014, vol. 6, no. 3, p. 121–127. .

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

petroleum ether and methanol
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Male/Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Number of organisms dosed:

6
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

100
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

increase of urea and creatinine levels; perivascular macrophage granuloma
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

Nephrotoxicity