EFSA Compendium of Botanicals

Draft - work in progress

Holoptelea integrifolia (Roxb.) Planch.

Family:: Ulmaceae
Approval state:: Approved
Number of articles retrieved:: 189
Number of processed references:: 4

Compositions

#1: Calcium oxalate #2: Alkaloids #3: Tannins #4: Saponins #5: Coumarins

Endpoint Studies

#1: Mild damage to liver (increase in weight and histopathological findings) #2: Mild tubular congestion and glomerular congestion in kidney

Genotoxicity

Composition #1: Kumar, Dinesh., Kumar, Karunesh., Kumar, Sunil., Kumar, Tarun., Kumar, Ajay., Prakash, Om. Pharmacognostic evaluation of leaf and root bark of Holoptelea integrifolia Roxb. . asian pacific journal of tropical biomedicine, 2012, vol. 2, no. 3, p. 169–175. DOI: 10.1016/S2221-1691(12)60036-7. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

Calcium oxalate (RF-00003960-PAR)
Analytical method code:

Microscopic detection (F536A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Calcium oxalate

Composition #2: Rizwani, Ghazala Hafeez., Mahmud, Shaukat., Shareef, Huma., Perveen, Rehana., Ahmed, Maryam. Analgesic activity of various extracts of Holoptelea integrifolia (Roxb.) Planch leaves . pakistan journal of pharmaceutical sciences, 2012, vol. 25, no. 3, p. 629–632. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #3: Rizwani, Ghazala Hafeez., Mahmud, Shaukat., Shareef, Huma., Perveen, Rehana., Ahmed, Maryam. Analgesic activity of various extracts of Holoptelea integrifolia (Roxb.) Planch leaves . pakistan journal of pharmaceutical sciences, 2012, vol. 25, no. 3, p. 629–632. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #4: Rizwani, Ghazala Hafeez., Mahmud, Shaukat., Shareef, Huma., Perveen, Rehana., Ahmed, Maryam. Analgesic activity of various extracts of Holoptelea integrifolia (Roxb.) Planch leaves . pakistan journal of pharmaceutical sciences, 2012, vol. 25, no. 3, p. 629–632. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #5: Subash, Arun Koorappally., Augustine, Anu. Hypolipidaemic Effects of Methanol Extract of Holoptelea integrifolia (Roxb.) Planchon Bark in Diet-Induced Obese Rats. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2013, vol. 169, no. 2, p. 546–553. DOI: 10.1007/s12010-012-9993-0. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 70% v/v
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

3-(7-ethoxy-4-methyl-2-oxo-2H-chromen-3-yl)propanoate
Analytical method code:

LC-MS/MS (F027A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins

Endpoint study #1: Kumar, D., Patil, P., Hegde, H.V., Roy, S., Kholkute, S. Safety evaluation of petroleum ether, Acetone and hydroalcoholic extracts of holoptelea integrifolia (ROXB.) Planch. Bark by oral administration in wistar rats. Asian Journal of Pharmaceutical and Clinical Research, 2015, vol. 8, no. 2, p. 185–189. .

Study relevance:

Human health
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Pet.Ether and acetone
Type of toxicological test:

short-term toxicity (CHD017TT)
Guideline used:

According to
Guideline:

OECD GUIDELINE 407 (REPEATED DOSE 28-DAY ORAL TOXICITY IN RODENTS) (OECD1255PL)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

28.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

60
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Microgram/kilogram (G050A)
Effect concentration:

100-200
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

petroleum ether and acetone extracts of the plant showed mild damage to liver as observed by the increase in liver weight and histopathological findings (Inflammation, central vein congestion, portal triaditis and spotty necrosis)
Effect or parameter linked to the endpoint:

organ weights (CHD012BE)
Internal remarks:

Mild damage to liver (increase in weight and histopathological findings)

Endpoint study #2: Kumar, D., Patil, P., Hegde, H.V., Roy, S., Kholkute, S. Safety evaluation of petroleum ether, Acetone and hydroalcoholic extracts of holoptelea integrifolia (ROXB.) Planch. Bark by oral administration in wistar rats. Asian Journal of Pharmaceutical and Clinical Research, 2015, vol. 8, no. 2, p. 185–189. .

Study relevance:

Human health
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

acetone
Type of toxicological test:

short-term toxicity (CHD017TT)
Guideline used:

According to
Guideline:

OECD GUIDELINE 407 (REPEATED DOSE 28-DAY ORAL TOXICITY IN RODENTS) (OECD1255PL)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

28.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

60
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Microgram/kilogram (G050A)
Effect concentration:

100
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

Mild tubular congestion and glomerular congestion were observed in kidneys of acetone extract treated group
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

Mild tubular congestion and glomerular congestion in kidney