EFSA Compendium of Botanicals

Draft - work in progress

Heracleum candicans Wall. ex DC.

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 86
Number of processed references:: 6

Compositions

#1: Furanocoumarins #2: heraclenol (furanocoumarin) #3: heraclenin (furanocoumarin) #4: candibirins F to H #5: canditririns C to E (furanocoumarins) #6: canditetrarin A & B (furanocoumarins) #7: Furanocoumarins #8: Myrcene

Endpoint Studies

Genotoxicity

Composition #1: Devagiri, G.M., Rastogi, J.S., Chand, R., Srivastava, L. Preliminary evaluation of some Hercleum candicans wall collections from Himachal Pradesh for furocoumarin content. Indian Drugs, 1995, vol. 32, no. 8, p. 381–386. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Furanocoumarins (RF-00004381-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

TLC-Spectrophometric method
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.01-9.47
Internal remarks:

Furanocoumarins

Composition #2: Rastogi, Subha., Pandey, Madan M., Rawat, Ajay K. S. Determination of heracienin and heracienol in Heracieum candicans DC by TLC. CHROMATOGRAPHIA, 2007, vol. 66, no. 7-8, p. 631–634. DOI: 10.1365/s10337-007-0357-9. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

heraclenol (RF-00011111-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:

HPTLC
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.29-0.433
Internal remarks:

heraclenol (furanocoumarin)

Composition #3: Rastogi, Subha., Pandey, Madan M., Rawat, Ajay K. S. Determination of heracienin and heracienol in Heracieum candicans DC by TLC. CHROMATOGRAPHIA, 2007, vol. 66, no. 7-8, p. 631–634. DOI: 10.1365/s10337-007-0357-9. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

heraclenin (RF-00011110-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:

HPTLC
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.02-1.367
Internal remarks:

heraclenin (furanocoumarin)

Composition #4: Inoue, Atsuko., Taniguchi, Masahiko., Shibano, Makio., Wang, Nian-He., Baba, Kimiye. Chemical studies on the root of Heracleum candicans Wall. (Part 3). JOURNAL OF NATURAL MEDICINES, 2010, vol. 64, no. 2, p. 175–181. DOI: 10.1007/s11418-010-0394-9. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Candibirins (RF-00010797-PAR)
Additional substance description:

candibirins F to H
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

ORD, UV, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

candibirins F to H

Composition #5: Taniguchi, Masahiko., Inoue, Atsuko., Shibano, Makio., Wang, Nian-He., Baba, Kimiye. Five condensed furanocoumarins from the root of Heracleum candicans Wall.. JOURNAL OF NATURAL MEDICINES, 2011, vol. 65, no. 2, p. 268–274. DOI: 10.1007/s11418-010-0488-4. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Canditririns (RF-00010795-PAR)
Additional substance description:

canditririns C to E
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

ORD, UV, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

canditririns C to E (furanocoumarins)

Composition #6: Taniguchi, Masahiko., Inoue, Atsuko., Shibano, Makio., Wang, Nian-He., Baba, Kimiye. Five condensed furanocoumarins from the root of Heracleum candicans Wall.. JOURNAL OF NATURAL MEDICINES, 2011, vol. 65, no. 2, p. 268–274. DOI: 10.1007/s11418-010-0488-4. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Canditetrarins (RF-00010796-PAR)
Additional substance description:

canditetrarins A & B
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

ORD, UV, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

canditetrarin A & B (furanocoumarins)

Composition #7: Rawat, A. K. S., Singh, A. P., Singh, D. P., Pandey, M. M., Govindarajan, R., Srivastava, Sharad. Separation and Identification of Furocoumarin in Fruits of Heracleum candicans DC. by HPTLC. JOURNAL OF CHEMISTRY, 2013 . DOI: 10.1155/2013/915762. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Furanocoumarins (RF-00004381-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:

HPTLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furanocoumarins

Composition #8: Chauhan, R. S., Nautiyal, M. C., Tava, A., Cecotti, R. Essential oil composition from leaves of Heracleum candicans Wall.: a sustainable method for extraction. JOURNAL OF ESSENTIAL OIL RESEARCH, 2014, vol. 26, no. 2, p. 130–132. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.9
Internal remarks:

Myrcene