EFSA Compendium of Botanicals

Draft - work in progress

Hedysarum polybotrys Hand.-Mazz.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 167
Number of processed references:: 6

Compositions

#1: ononin #2: Formononetin #3: calycosin #4: Phenylpropanoids #5: 7-Methylbenzofuran #6: Saponins (astragaloside III and IV) #7: Isoflavones #8: Triterpene saponins

Endpoint Studies

Genotoxicity

Composition #1: Hai Li-qian., Zhang Qing-ying., Liang Hong., Zhao Yu-ying., Du Nian-sheng. Studies on chemical constituents of Hedysarum polybotrys.. yaoxue xuebao, 2003, vol. 38, no. 8, p. 592–595. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Ononin (RF-00011023-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

ononin

Composition #2: Hai Li-qian., Zhang Qing-ying., Liang Hong., Zhao Yu-ying., Du Nian-sheng. Studies on chemical constituents of Hedysarum polybotrys.. yaoxue xuebao, 2003, vol. 38, no. 8, p. 592–595. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

formononetin (RF-00000291-NTR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Formononetin

Composition #3: Hai Li-qian., Zhang Qing-ying., Liang Hong., Zhao Yu-ying., Du Nian-sheng. Studies on chemical constituents of Hedysarum polybotrys.. yaoxue xuebao, 2003, vol. 38, no. 8, p. 592–595. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

calycosin (RF-00004191-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

calycosin

Composition #4: Cheng Fan., Zou Kun., Zhu Shu., Katsuko, Komatsu. A New Phenylpropionate Derivative from the Rhizomes of Hedysarum polybotrys . chinese journal of natural medicines, 2009, vol. 7, no. 5, p. 351–353. DOI: 10.3724/SP.J.1009.2009.00351. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

phenylpropanoids (RF-00004367-PAR)
Additional substance description:

(E)-3-(4-hydroxy-2-methoxyphenyl)-propenoic acid 4-hydroxy-3-methoxyphenyl ester
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Phenylpropanoids

Composition #5: Chen, Yaozu., Wang, Rui., Xue, Dongyuan., Li, Zhaolin., Han, Hui. Analysis of volatile constituents of Hedysarum polybotrys Hand. by capillary gas chromatography-mass spectrometry. gaodeng xuexiao huaxue xuebao, 1987, p. 538–541. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

7-methylbenzofuran
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.8
Internal remarks:

7-Methylbenzofuran

Composition #6: Qin, Hongping., Lu, Jing., Lin, Ruichao. Determination of astragaloside I, II, III and IV in Radix Astragali by HPLC-ELSD. zhongcaoyao, 2009, p. 471–473. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

astragalosides III and IV
Analytical method code:

HPLC-ELSD (F327A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins (astragaloside III and IV)

Composition #7: Zhao, Jing., Yu, Qing-Tao., Li, Ping., Zhou, Peng., Zhang, Yuan-Jie., Wang, Wei. Determination of nine active components in Radix Hedysari and Radix Astragali using capillary HPLC with diode array detection and MS detection . journal of separation science, 2008, vol. 31, no. 2, p. 255–261. DOI: 10.1002/jssc.200700379. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

isoflavones (RF-00004359-PAR)
Additional substance description:

(3R)-29-hydroxy-39,49- dimethoxyisoflavan-7-O-b-D-glucoside, and (3R)-8,29-dihydroxy-7,49-dimethoxyisoflavan
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

HPLC-DAD-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoflavones

Composition #8: Liu, Yi., Zhao, Yuying., Chen, Hubiao., Wang, Bin., Zhang, Qingying. Structure elucidation and complete NMR spectral assignment of two triterpenoid saponins from Radix Hedysari. FITOTERAPIA, 2009, vol. 80, no. 2, p. 127–129. DOI: 10.1016/j.fitote.2008.12.001. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Additional substance description:

polybosaponin A and dehydrosoyasaponin I
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

C and H NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Triterpene saponins