EFSA Compendium of Botanicals

Draft - work in progress

Harrisonia abyssinica Oliv.

Family:: Rutaceae
Approval state:: Approved
Number of articles retrieved:: 70
Number of processed references:: 5

Compositions

#1: Triterpene saponins #2: Limonoids (Calodendrolide, Pyroangolensolide) #3: Total tannins #4: Condensed tannins #5: Chebulagic acid and derivatives #6: harrisonine and derivatives #7: atalantolide #8: obacunone #9: pedonin

Endpoint Studies

Genotoxicity

Composition #1: Kareru, P. G., Keriko, J. M., Gachanja, A. N., Kenji, G. M. Direct detection of triterpenoid saponins in medicinal plants. african journal of traditional, complementary and alternative medicines, 2008, p. 56–60. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hot water extraction
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Triterpene saponins

Composition #2: Kiprop, Ambrose Kipchumba., Kiprono, Paul Chepkwony., Rajab, Mohammed Said., Kosgei, Mathew Kipchumba. Limonoids as larvicidal components against mosquito larvae (Aedes aegypti Linn.) . zeitschrift fur naturforschung section c-a journal of biosciences, 2007, vol. 62, no. 11-12, p. 826–828. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extract of dried ground root barks
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

Limonoids (Calodendrolide, Pyroangolensolide)
Analytical method code:

IR and Raman Spectroscopy (F010A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Limonoids (Calodendrolide, Pyroangolensolide)

Composition #3: Rubanza, Chrispinus D. K., Shem, Martin N., Ichinohe, Toshiyoshi., Fujihara, Tsutomu. Quantification and characterisation of condensed tannin of selected indigenous browse tree species leaves of north-western Tanzania . journal of food agriculture & environment, 2008, vol. 6, no. 2, p. 145–149. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Aqueous acetone (7:3 v/v) in water
Substance:

Tannins (RF-00004337-PAR)
Additional substance description:

Total tannins
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

193.3
Internal remarks:

Total tannins

Composition #4: Rubanza, Chrispinus D. K., Shem, Martin N., Ichinohe, Toshiyoshi., Fujihara, Tsutomu. Quantification and characterisation of condensed tannin of selected indigenous browse tree species leaves of north-western Tanzania . journal of food agriculture & environment, 2008, vol. 6, no. 2, p. 145–149. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Aqueous acetone (7:3 v/v) in water
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

54.3
Internal remarks:

Condensed tannins

Composition #5: Lee, Won Jeong., Moon, Jae Sun., Kim, Sung In., Kim, Young Tae., Nash, Oyekanmi., Bahn, Yong-Sun., Kim, Sung Uk. Inhibition of the Calcineurin Pathway by Two Tannins, Chebulagic Acid and Chebulanin, Isolated from Harrisonia abyssinica Oliv.. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2014, vol. 24, no. 10, p. 1377–1381. DOI: 10.4014/jmb.1405.05030. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate
Substance:

Chebulagic acid (RF-00010972-PAR)
Additional substance description:

Chebulagic acid and derivatives
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Chebulagic acid and derivatives

Composition #6: Rajab, MS., Rugutt, JK., Fronczek, FR., Fischer, NH. Structural revision of harrisonin and 12 beta-acetoxyharrisonin, two limonoids from Harrisonia abyssinica. JOURNAL OF NATURAL PRODUCTS, 1997, vol. 60, no. 8, p. 822–825. DOI: 10.1021/np970201p. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol with further modification
Substance:

Harrisonin (RF-00011200-PAR)
Additional substance description:

Harrisonin and derivatives. The amount of harrisonin is in the oil extracted from bark
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.2
Internal remarks:

harrisonine and derivatives

Composition #7: Rajab, MS., Rugutt, JK., Fronczek, FR., Fischer, NH. Structural revision of harrisonin and 12 beta-acetoxyharrisonin, two limonoids from Harrisonia abyssinica. JOURNAL OF NATURAL PRODUCTS, 1997, vol. 60, no. 8, p. 822–825. DOI: 10.1021/np970201p. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol with further modification
Substance:

Atalantolide (RF-00011201-PAR)
Additional substance description:

amount of compound in the oil extracted from bark
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.8
Internal remarks:

atalantolide

Composition #8: Rajab, MS., Rugutt, JK., Fronczek, FR., Fischer, NH. Structural revision of harrisonin and 12 beta-acetoxyharrisonin, two limonoids from Harrisonia abyssinica. JOURNAL OF NATURAL PRODUCTS, 1997, vol. 60, no. 8, p. 822–825. DOI: 10.1021/np970201p. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol with further modification
Substance:

obacunone (RF-00011198-PAR)
Additional substance description:

The amount of compound is in the oil extracted from bark
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

15
Internal remarks:

obacunone

Composition #9: Rajab, MS., Rugutt, JK., Fronczek, FR., Fischer, NH. Structural revision of harrisonin and 12 beta-acetoxyharrisonin, two limonoids from Harrisonia abyssinica. JOURNAL OF NATURAL PRODUCTS, 1997, vol. 60, no. 8, p. 822–825. DOI: 10.1021/np970201p. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol with further modification
Substance:

Pedonin (RF-00011437-PAR)
Additional substance description:

The amount reported for the compound is in the oil extracted from bark
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

10.0
Internal remarks:

pedonin