EFSA Compendium of Botanicals

Draft - work in progress

Gypsophila paniculata L.

Family:: Caryophyllaceae
Approval state:: Approved
Number of articles retrieved:: 394
Number of processed references:: 6

Compositions

#1: Triterpenoid saponins caryophyllacosides A and B #2: Saponins (saponalbin and methylsaponalbin) #3: Saponins (saponin glycosides ) more in roots than in flower #4: Triterpene saponins #5: Gypsogenin 3-O-glucuronide (saponin) #6: Gypsogenin 3-O-glucuronide (saponin) #7: Quillaic acid 3-O-glucuronide (saponin)

Endpoint Studies

#1: Enzyme inhibition of alfa-glucosidase #2: alfa-glucosidase inhibition

Genotoxicity

Composition #1: Yao Shun., Luo Jian-Guang., Ma Li., Kong Ling-Yi. Two New Triterpenoid Saponins from the Roots of Gypsophila paniculata with Potent alpha-Glucosidase Inhibition Activity . chinese journal of natural medicines, 2011, vol. 9, no. 6, p. 401–405. DOI: 10.3724/SP.J.1009.2011.00401. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

75% EtOH
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Additional substance description:

Caryophyllacosides A and B
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Triterpenoid saponins caryophyllacosides A and B

Composition #2: Vacek, Lubor., Sedlak, Bretislav. Comparison of physical, chemical, and biological properties of saponins. gunma journal of medical sciences, 1962, p. 1–6. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

saponalbin and methylsaponalbin
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins (saponalbin and methylsaponalbin)

Composition #3: Kolodziejski, I. Jozef., Stecka, Leokadia. Occurrence of saponins in various parts of Gypsophila paniculata and Gypsophila altissima. farmacja polska, 1965, p. 751–754. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

saponin glycosides
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

19.0
Internal remarks:

Saponins (saponin glycosides ) more in roots than in flower

Composition #4: Yao, Shun., Ma, Li., Luo, Jian-Guang., Wang, Jun-Song., Kong, Ling-Yi. New Triterpenoid Saponins from the Roots of Gypsophila paniculata L.. helvetica chimica acta, 2010, vol. 93, no. 2, p. 361–374. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol (75%)
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Additional substance description:

3,28-O-bidesmosides and derivatives
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Triterpene saponins

Composition #5: Gevrenova, Reneta., Stancheva, Tanya., Voynikov, Yulian., Laurain-Mattar, Dominique., Henry, Max. Root in vitro cultures of six Gypsophila species and their saponin contents . enzyme and microbial technology, 2010, vol. 47, no. 3, p. 97–104. DOI: 10.1016/j.enzmictec.2010.05.007. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

gypsogenin (RF-00004436-PAR)
Additional substance description:

Gypsogenin 3-O-glucuronide
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.11-0.34
Internal remarks:

Gypsogenin 3-O-glucuronide (saponin)

Composition #6: Gevrenova, R., Joubert, O., Mandova, Tsv., Zaiou, M., Chapleur, Y., Henry, M. Cytotoxic effects of four Caryophyllaceae species extracts on macrophage cell lines . pharmaceutical biology, 2014, vol. 52, no. 7, p. 919–925. DOI: 10.3109/13880209.2013.868492. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Powder (A06JD)
Additional extraction description:

lyophilized extract
Substance:

gypsogenin (RF-00004436-PAR)
Additional substance description:

Gypsogenin 3-O-glucuronide
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

SPE ; UPLC-ESI/MS
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.52
Internal remarks:

Gypsogenin 3-O-glucuronide (saponin)

Composition #7: Gevrenova, R., Joubert, O., Mandova, Tsv., Zaiou, M., Chapleur, Y., Henry, M. Cytotoxic effects of four Caryophyllaceae species extracts on macrophage cell lines . pharmaceutical biology, 2014, vol. 52, no. 7, p. 919–925. DOI: 10.3109/13880209.2013.868492. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Powder (A06JD)
Additional extraction description:

lyophilized extract
Substance:

Quillaic Acid (RF-00010959-PAR)
Additional substance description:

Quillaic acid 3-O-glucuronide
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

SPE ; UPLC-ESI/MS
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.3
Internal remarks:

Quillaic acid 3-O-glucuronide (saponin)

Endpoint study #1: Yao Shun., Luo Jian-Guang., Ma Li., Kong Ling-Yi. Two New Triterpenoid Saponins from the Roots of Gypsophila paniculata with Potent alpha-Glucosidase Inhibition Activity . chinese journal of natural medicines, 2011, vol. 9, no. 6, p. 401–405. DOI: 10.3724/SP.J.1009.2011.00401. [DOI link]

Study relevance:

Human health
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanolic
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Millimole/litre (G071A)
Effect concentration:

0.1-0.4
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

Enzyme inhibition of alfa-glucosidase
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Enzyme inhibition of alfa-glucosidase

Endpoint study #2: Yao, Shun., Ma, Li., Luo, Jian-Guang., Wang, Jun-Song., Kong, Ling-Yi. New Triterpenoid Saponins from the Roots of Gypsophila paniculata L.. helvetica chimica acta, 2010, vol. 93, no. 2, p. 361–374. .

Study relevance:

Human health
Substance:

Saponins (RF-00004333-PAR)
Additional plant/substance description:

saponin - compound number 1
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Percent (G138A)
Effect concentration:

100.9
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alfa-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alfa-glucosidase inhibition