EFSA Compendium of Botanicals

Draft - work in progress

Gleditsia sinensis Lam.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 540
Number of processed references:: 5

Compositions

#1: Triterpene saponins #2: Saponins - Gleditsiosides O (pod) #3: saponins #4: Isoquinoline alkaloids #5: Saponins #6: Saponins

Endpoint Studies

Genotoxicity

Composition #1: Liu C., Sun H., Wang WT., Zhang JB., Cheng AW., Guo X., Sun JY. A new triterpenoid saponin from Gleditsia sinensis and its antiproliferativeactivity.. Natural product research, 2015, p. 1–6. DOI: 10.1080/14786419.2015.1110704. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Additional substance description:

3-O-β-Dxylopyranosyl-( 1 → 2)-α-L-arabinopyranosyl-(1 → 6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyrano-- syl-(1 → 4)-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 3)-β-Dglucopyranosyl ester
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

NMR, IR, HR-ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Triterpene saponins

Composition #2: Zhang Hongli., Jian Liru., Han Chongxuan., Wang Mingchun., Yang Qinge. Isolation, Identification and Toxicity of Gleditsiosides O. xibei zhiwu xuebao, 2013, vol. 33, no. 6, p. 1234–1238. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

Gleditsiosides O
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins - Gleditsiosides O (pod)

Composition #3: Bo, T., Zhong, L., Li, M., Luo, YQ., Li, KA., Liu, HW., Guo, DA. Separation of isoquinoline alkaloids and saponins by microemulsion electrokinetic chromatography with anionic and cationic surfactants. CHROMATOGRAPHIA, 2002, vol. 56, no. 11-12, p. 709–716. DOI: 10.1007/BF02492472. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

Microemulsion Electrokinetic Chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins

Composition #4: Bo, T., Zhong, L., Li, M., Luo, YQ., Li, KA., Liu, HW., Guo, DA. Separation of isoquinoline alkaloids and saponins by microemulsion electrokinetic chromatography with anionic and cationic surfactants. CHROMATOGRAPHIA, 2002, vol. 56, no. 11-12, p. 709–716. DOI: 10.1007/BF02492472. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

jatrorrhizine, berberine, berbamine, thalifaretine, thalifaricine, northalfine, tetrahydrocoptizine, palmatine, (+)-tetrandrine, and thalistine
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

Microemulsion Electrokinetic Chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids

Composition #5: Zhong, L., Li, P., Han, J., Qu, GQ., Guo, D. Structure-activity relationships of saponins from Gleditsia sinensis in cytotoxicity and induction of apoptosis. PLANTA MEDICA, 2004, vol. 70, no. 9, p. 797–802. DOI: 10.1055/s-2004-827225. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

70 % Ethanol
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

Gletidsiosides A-Q; Gleditsia saponin B and C.
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

C and H NMR, HPLC , MALDI-TOF MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #6: Lian, Xiao-Yuan., Zhang, Zhizhen. Quantitive analysis of gleditsia saponins in the fruits of Gleditsia sinensis Lam. by high performance liquid chromatography . journal of pharmaceutical and biomedical analysis, 2013, vol. 75, p. 41–46. DOI: 10.1016/j.jpba.2012.11.007. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

gleditsia saponin B, C and E ; gleditsioside H, J, K Q, I, C, D, E, B, G, F,A,N,O,and P)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.137-11.479
Internal remarks:

Saponins