EFSA Compendium of Botanicals

Draft - work in progress

Geranium pratense L.

Family:: Geraniaceae
Approval state:: Approved
Number of articles retrieved:: 128
Number of processed references:: 4

Compositions

#1: Tannins (aerial part) #2: Tannins (underground part) #3: Gallic acid #4: Gallotannins (Methtylgallate; myricetin-3-O-(2"-O-galloyl)-beta-D-glucopyranoside; quercetin-3-O-(2"-galloyl)-beta-D- galactopyranoside; (-)-6-chloroepicatechin.)

Endpoint Studies

#1: In vitro mouse alpha-amylase inhibition of the methanolic extract of the aerial part

Genotoxicity

Composition #1: Buckova, A., Leifertova, I., Natherova, L. Content of tannins in Geranium pratense. II. cesko-slovenska farmacie, 1965, p. 406–409. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

alcohol, water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

12-20
Internal remarks:

Tannins (aerial part)

Composition #2: Buckova, A., Leifertova, I., Natherova, L. Content of tannins in Geranium pratense. II. cesko-slovenska farmacie, 1965, p. 406–409. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

alcohol, water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

19-34
Internal remarks:

Tannins (underground part)

Composition #3: Xie, Song., Song, Liang-ke., Wan, Jun., Tong, Zhi-ping., Tan, Rui., Liu, Xiao-zhen. Determination of shikimic acid and gallic acid in Geranium pratense by HPLC. zhongchengyao, 2014, p. 2554–2556. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.4
Internal remarks:

Gallic acid

Composition #4: Akdemir, ZS., Tatli, II., Saracoglu, I., Ismailoglu, UB., Sahin-Erdemli, I., Calis, I. Polyphenolic compounds from Geranium pratense and their free radical scavenging activities. PHYTOCHEMISTRY, 2001, vol. 56, no. 2, p. 189–193. DOI: 10.1016/S0031-9422(00)00367-8. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Gallotannins (RF-00013316-PAR)
Additional substance description:

Methtylgallate; myricetin-3-O-(2"-O-galloyl)-beta-D-glucopyranoside; quercetin-3-O-(2"-galloyl)-beta-D- galactopyranoside; (-)-6-chloroepicatechin.
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Gallotannins (Methtylgallate; myricetin-3-O-(2"-O-galloyl)-beta-D-glucopyranoside; quercetin-3-O-(2"-galloyl)-beta-D- galactopyranoside; (-)-6-chloroepicatechin.)

Endpoint study #1: Kobayashi, K., Baba, E., Fushiya, S., Takano, F., Batkhuu, J., Dash, T., Sanchir, C., Yoshizaki, F. Screening of mongolian plants for influence on amylase activity in mouse plasma and gastrointestinal tube . biological & pharmaceutical bulletin, 2003, vol. 26, no. 7, p. 1045–1048. .

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Methanol
Type of toxicological test:

in vitro (CHD061TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Percent (G138A)
Effect concentration:

43.9
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Pancreas (TT024A)
Effect description:

mouse alpha-amylase in vitro inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

In vitro mouse alpha-amylase inhibition of the methanolic extract of the aerial part