EFSA Compendium of Botanicals

Draft - work in progress

Galanthus woronowii Losinsk.

Family:: Amaryllidaceae
Approval state:: Approved
Number of articles retrieved:: 41
Number of processed references:: 4

Compositions

#1: tazettine (bulb) #2: galanthine (bulb) #3: Alkaloids (aerial parts, quantified) #4: Alkaloids (bulb, quantified) #5: lycorine (bulb, quantif) #6: lycorine (aerial part, quantif) #7: galanthamine (bulb, quant) #8: galanthamine (aerial parts, quant) #9: narwedine #10: Alkaloids (O-methylleucotamine, sanguinine) #11: sternbergine #12: salsoline

Endpoint Studies

Genotoxicity

Composition #1: Kintsurashvili, L., Vachnadze, V. Plants of the Amaryllidaceae family grown and introduced in Georgia: A source of galanthamine. pharmaceutical chemistry journal, 2007, vol. 41, no. 9, p. 492–494. DOI: 10.1007/s11094-007-0110-6. [DOI link]

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

tazettine (RF-00003599-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tazettine (bulb)

Composition #2: Kintsurashvili, L., Vachnadze, V. Plants of the Amaryllidaceae family grown and introduced in Georgia: A source of galanthamine. pharmaceutical chemistry journal, 2007, vol. 41, no. 9, p. 492–494. DOI: 10.1007/s11094-007-0110-6. [DOI link]

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

galanthine (RF-00011028-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

galanthine (bulb)

Composition #3: Emir, A., Somer, N.Ü., Kaya, G.I., Sarikaya, B., Önür, M.A. Quality control evaluation and acetylcholinesterase inhibitory activity of Galanthus woronowii Losinsk Galanthus woronowii Losinsk.'in kalite kontrol açi{dotless}si{dotless}ndan deǧerlendirilmesi ve asetilkolinesteraz inhibitör aktivitesi . marmara pharmaceutical journal, 2011, vol. 15, no. 2, p. 48–51. DOI: 10.12991/201115431. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Volumetric tests (F005A)
Analytical method - additional description:

titrimetric method
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.247-0.499
Internal remarks:

Alkaloids (aerial parts, quantified)

Composition #4: Emir, A., Somer, N.Ü., Kaya, G.I., Sarikaya, B., Önür, M.A. Quality control evaluation and acetylcholinesterase inhibitory activity of Galanthus woronowii Losinsk Galanthus woronowii Losinsk.'in kalite kontrol açi{dotless}si{dotless}ndan deǧerlendirilmesi ve asetilkolinesteraz inhibitör aktivitesi . marmara pharmaceutical journal, 2011, vol. 15, no. 2, p. 48–51. DOI: 10.12991/201115431. [DOI link]

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Volumetric tests (F005A)
Analytical method - additional description:

titrimetric method
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.250-0.412
Internal remarks:

Alkaloids (bulb, quantified)

Composition #5: Emir, A., Polat, D. Cicek., Kaya, G. I., Sarikaya, B., Onur, M. A., Somer, N. Unver. Simultaneous Determination of Lycorine and Galanthamine in Galanthus woronowii by HPLC-DAD . acta chromatographica, 2013, vol. 25, no. 4, p. 755–764. DOI: 10.1556/AChrom.25.2013.4.13. [DOI link]

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

lycorine (RF-00003913-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.038-0.364
Internal remarks:

lycorine (bulb, quantif)

Composition #6: Emir, A., Polat, D. Cicek., Kaya, G. I., Sarikaya, B., Onur, M. A., Somer, N. Unver. Simultaneous Determination of Lycorine and Galanthamine in Galanthus woronowii by HPLC-DAD . acta chromatographica, 2013, vol. 25, no. 4, p. 755–764. DOI: 10.1556/AChrom.25.2013.4.13. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

lycorine (RF-00003913-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.008-0.234
Internal remarks:

lycorine (aerial part, quantif)

Composition #7: Emir, A., Polat, D. Cicek., Kaya, G. I., Sarikaya, B., Onur, M. A., Somer, N. Unver. Simultaneous Determination of Lycorine and Galanthamine in Galanthus woronowii by HPLC-DAD . acta chromatographica, 2013, vol. 25, no. 4, p. 755–764. DOI: 10.1556/AChrom.25.2013.4.13. [DOI link]

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

galanthamine (RF-00003399-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.017-0.506
Internal remarks:

galanthamine (bulb, quant)

Composition #8: Emir, A., Polat, D. Cicek., Kaya, G. I., Sarikaya, B., Onur, M. A., Somer, N. Unver. Simultaneous Determination of Lycorine and Galanthamine in Galanthus woronowii by HPLC-DAD . acta chromatographica, 2013, vol. 25, no. 4, p. 755–764. DOI: 10.1556/AChrom.25.2013.4.13. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

galanthamine (RF-00003399-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.003-0.326
Internal remarks:

galanthamine (aerial parts, quant)

Composition #9: Sarikaya, Buket Bozkurt., Kaya, Gulen Irem., Onur, Mustafa Ali., Bastida, Jaume., Somer, Nehir Unver. Phytochemical investigation of Galanthus woronowii. biochemical systematics and ecology, 2013, vol. 51, p. 276–279. DOI: 10.1016/j.bse.2013.09.015. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

extracted with CHCI3
Substance:

narwedine (RF-00003505-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

UV, IR, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

narwedine

Composition #10: Sarikaya, Buket Bozkurt., Kaya, Gulen Irem., Onur, Mustafa Ali., Bastida, Jaume., Somer, Nehir Unver. Phytochemical investigation of Galanthus woronowii. biochemical systematics and ecology, 2013, vol. 51, p. 276–279. DOI: 10.1016/j.bse.2013.09.015. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

extracted with CHCI3
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

O-methylleucotamine, sanguinine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

UV, IR, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids (O-methylleucotamine, sanguinine)

Composition #11: Sarikaya, Buket Bozkurt., Kaya, Gulen Irem., Onur, Mustafa Ali., Bastida, Jaume., Somer, Nehir Unver. Phytochemical investigation of Galanthus woronowii. biochemical systematics and ecology, 2013, vol. 51, p. 276–279. DOI: 10.1016/j.bse.2013.09.015. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

extracted with CHCI3
Substance:

sternbergine (RF-00003589-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

UV, IR, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sternbergine

Composition #12: Sarikaya, Buket Bozkurt., Kaya, Gulen Irem., Onur, Mustafa Ali., Bastida, Jaume., Somer, Nehir Unver. Phytochemical investigation of Galanthus woronowii. biochemical systematics and ecology, 2013, vol. 51, p. 276–279. DOI: 10.1016/j.bse.2013.09.015. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

extracted with CHCI3
Substance:

salsoline (RF-00003571-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

UV, IR, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

salsoline