Draft - work in progress
-
- Forsythia suspensa (Thunb.) Vahl
Forsythia suspensa (Thunb.) Vahl
- Family:
- Oleaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 1237
- Number of processed references:
- 5
Composition #1: Tsukamoto, Hiroki., Hisada, Sueo., Nishibe, Sansei. Studies on the lignans from Oleaceae plants. tennen yuki kagobutsu toronkai koen yoshishu, 1983, p. 181–188. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Substance:
lignans (RF-00004361-PAR)
-
Additional substance description:
(+)-Epipinoresinol-4"-β-D-glucoside
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
lignans (bark)
Composition #2: Kitagawa, Shizuka., Nishibe, Sansei., Benecke, Renate., Thieme, Heinz. Phenolic compounds from Forsythia leaves. II. chemical pharmaceutical bulletin, 1988, p. 3667–3670. .
-
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
lignans (RF-00004361-PAR)
-
Additional substance description:
phillygenin
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
lignan (leaves, phyllogenin)
Composition #3: Luan, Lan., Wang, Gang-li., Lin, Rui-chao. Studies on the chemical constituents of extract with water from Forsythia suspensa . . zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2010, vol. 33, no. 2, p. 220–1. .
-
-
Plant part:
Unspecified (A07XD)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Water extract
-
Substance:
lignans (RF-00004361-PAR)
-
Additional substance description:
isolariciresinol, epipinoresinol-4-O-beta-D-glucoside,(+)-epipinoresionl,(+)-pino resinol
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Lignans (isolariciresinol, epipinoresinol-4-O-beta-D-glucoside,(+)-epipinoresionl,(+)-pino resinol)
Composition #4: Wang, Yaqin., Guo, Zhimou., Jin, Yu., Zhang, Xiuli., Li, Wei., Liang, Xinmiao. Selective enrichment with "click oligo (ethylene glycol)" column and TOF-MS characterization of simple phenylpropanoids in the fruits of Forsythia suspensa . journal of separation science, 2009, vol. 32, no. 17, p. 2958–2966. DOI: 10.1002/jssc.200900150.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
aqueous extract
-
Substance:
lignans (RF-00004361-PAR)
-
Analytical method code:
Chromatographic tests (F015A)
-
Analytical method - additional description:
ultra-performance liquid chromatography (UPLC)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
lignans (fruit)
Genotox #1: YIN, XJ., LIU, DX., WANG, HC., ZHOU, Y. A STUDY ON THE MUTAGENICITY OF 102 RAW PHARMACEUTICALS USED IN CHINESE TRADITIONAL MEDICINE . mutation research, 1991, vol. 260, no. 1, p. 73–82. .
-
Study category:
Genotoxicity
-
Type of toxicological test:
chromosome aberration assay (CHD047TT)
-
-
Tested organism:
House mouse (as animal) (A0CNT)
-
-
Exogenous metabolic activation applied:
not applicable
-
Route of exposure:
OTHER (OECD0PL)
-
Number of organisms dosed:
40
-
Control groups used:
yes, concurrent vehicle
-
Endpoint measured:
chromosome aberration
-
-
Remarks on genotox study:
Positive result
-
Internal remarks:
Genotoxicity - Chromosomal aberration positive
-
Internal ID:
WOS:A1991FK36700010
Genotox #2: YIN, XJ., LIU, DX., WANG, HC., ZHOU, Y. A STUDY ON THE MUTAGENICITY OF 102 RAW PHARMACEUTICALS USED IN CHINESE TRADITIONAL MEDICINE . mutation research, 1991, vol. 260, no. 1, p. 73–82. .
-
Study category:
Genotoxicity
-
Type of toxicological test:
micronucleus assay (CHD051TT)
-
-
Tested organism:
House mouse (as animal) (A0CNT)
-
-
Exogenous metabolic activation applied:
not applicable
-
Route of exposure:
OTHER (OECD0PL)
-
Number of organisms dosed:
40
-
Control groups used:
yes, concurrent vehicle
-
Endpoint measured:
DNA damage and/or repair
-
-
Remarks on genotox study:
Positive micronucleus study in mice
-
Internal remarks:
Genotoxicity - Micronucleus assay positive
-
Internal ID:
WOS:A1991FK36700010